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- Shen, Li, et al.
(författare)
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An interactive 3D visualization and manipulation tool foreffective assessment of angiogenesis and arteriogenesis usingcomputed tomographic angiography
- 2005
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Ingår i: Progress in Biomedical Optics and Imaging. - : SPIE. - 1605-7422 .- 1042-4687. ; 5744:II, s. 848-858
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents IVM, an Interactive Vessel Manipulation tool that can help make effective and efficient assessmentof angiogenesis and arteriogenesis in computed tomographic angiography (CTA) studies. IVM consistsof three fundamental components: (1) a visualization component, (2) a tracing component, and (3) a measurementcomponent. Given a user-specified threshold, IVM can create a 3D surface visualization based on it. Sincevessels are thin and tubular structures, using standard isosurface extraction techniques usually cannot yieldsatisfactory reconstructions. Instead, IVM directly renders the surface of a derived binary 3D image. The imagevolumes collected in CTA studies often have a relatively high resolution. Thus, compared with more complicatedvessel extraction and visualization techniques, rendering the binary image surface has the advantages of beingeffective, simple and fast. IVM employs a semi-automatic approach to determine the threshold: a user can adjustthe threshold by checking the corresponding 3D surface reconstruction and make the choice. Typical tracingsoftware often defines ROIs on 3D image volumes using three orthogonal views. The tracing component in IVMtakes one step further: it can perform tracing not only on image slices but also in a 3D view. We observe thatdirectly operating on a 3D view can help a tracer identify ROIs more easily. After setting a threshold and tracingan ROI, a user can use IVM’s measurement component to estimate the volume and other parameters of vesselsin the ROI. The effectiveness of the IVM tool is demonstrated on rat vessel/bone images collected in a previousCTA study.
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- Zhuang, Zhen W., et al.
(författare)
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Arteriogenesis: Noninvasive quantification with multi-detector row CT angiography and three-dimensional volume rendering in rodents
- 2006
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Ingår i: Radiology. - : Radiological Society of North America (RSNA). - 0033-8419 .- 1527-1315. ; 240:3, s. 698-707
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE:To evaluate two-dimensional (2D) multi-detector row computed tomographic (CT) angiography and three-dimensional (3D) volume rendering for depiction of patterns of arterial growth and quantification of blood vessel density and volume.MATERIALS AND METHODS:The institutional animal care and use committee approved this study. The right femoral artery and its branches were ligated and excised in 16 inbred Lewis rats; animals were randomly assigned to receive 70 microL Dulbecco's modified Eagle's medium (DMEM) or 1.5 x 10(7) bone marrow-derived mononuclear cells (BMC) from isogenic donor rats in 70 microL DMEM. At 2 weeks, CT angiography was performed with injection of 0.45 mL barium sulfate suspension at 0.7 mL/min, followed by silver staining. Number of blood vessels, area, mean area, volume, and blood vessel size distribution derived from digitally subtracted 2D CT angiographic sections were quantified; 3D images were reconstructed. Two-way analysis of variance and paired and unpaired Student t tests were performed.RESULTS:CT angiography showed two patterns of arterial growth: collateral arterial formation and branching arteriogenesis. Two-way analysis of variance indicated that differences within subjects (ischemic vs nonischemic legs) and between subjects (BMC vs DMEM treatment) were significant for total blood vessel area, total blood vessel volume, and mean of blood vessel area (P < .001). In the BMC group, there were significantly more arteries (mean, 241.6 +/- 77.0 [standard deviation] vs 196.4 +/- 75.2, P = .028), but mean cross-sectional area of these arteries was smaller in ischemic versus nonischemic legs (5.4 mm(2) +/- 1.2 vs 6.8 mm(2) +/- 1.3, P = .006). Total arterial area and volume did not differ significantly between ischemic and nonischemic legs.CONCLUSION:BMC injection had a substantial effect on arteriogenesis, with normalization of total arterial area and volume in the BMC group; this effect was successfully depicted.
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