| 1. |
- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 5. |
- Abramovitz, T, et al.
(författare)
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MONA LISA : Deep seismic investigations of the lithosphere in the southeastern North Sea
- 1997
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Ingår i: TECTONOPHYSICS. - : ELSEVIER SCIENCE BV. - 0040-1951. ; 269:1-2, s. 1-19
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The MONA LISA collaborative project has collected 1112 km of seismic normal-incidence reflection data (recorded to 26 s) and wide-angle data from 26 onshore and 2 offshore locations along 4 profiles in the southeastern North Sea. The seismic data clearly
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| 6. |
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| 7. |
- AliRiahi, M, et al.
(författare)
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Three-dimensional image of the Moho undulations beneath the Gulf of Bothnia using wide-angle seismic data
- 1997
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Ingår i: GEOPHYSICAL JOURNAL INTERNATIONAL. - : BLACKWELL SCIENCE LTD. - 0956-540X. ; 129:2, s. 461-471
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The BABEL marine seismic experiment has been carried out to investigate the lithospheric structure and antecedent tectonic signatures of the Baltic Shield, including the Archaean-Proterozoic collisional structure in the northern part of the Gulf of Bothni
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| 8. |
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| 9. |
- Bastani, M, et al.
(författare)
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Automatic interpretation of magnetic dike parameters using the analytical signal technique
- 2001
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Ingår i: GEOPHYSICS. - : SOC EXPLORATION GEOPHYSICISTS. - 0016-8033. ; 66:2, s. 551-561
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Tidskriftsartikel (refereegranskat)abstract
- The analytical signal of the magnetic field is used to automatically determine the source parameters of dikelike structures. The method is particularly useful for interpreting large amounts of data collected during airborne surveys because it makes full u
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| 10. |
- Bastani, M, et al.
(författare)
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Estimation of magnetotelluric transfer functions from radio transmitters
- 2001
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Ingår i: GEOPHYSICS. - : SOC EXPLORATION GEOPHYSICISTS. - 0016-8033. ; 66:4, s. 1038-1051
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Tidskriftsartikel (refereegranskat)abstract
- A new method to estimate magnetatelluric (MT) transfer functions using radio transmitters as the source has been developed using an extended version of Weidelt's C function expansion. The expansion coefficients are found from solving a mixed determined li
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