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Sökning: WFRF:(Pehlivanoglu E)

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  • Zou, Zhiyuan V., et al. (författare)
  • Antioxidants promote intestinal tumor progression in mice.
  • 2021
  • Ingår i: Antioxidants. - : MDPI AG. - 2076-3921. ; 10:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Dietary antioxidants and supplements are widely used to protect against cancer, even though it is now clear that antioxidants can promote tumor progression by helping cancer cells to overcome barriers of oxidative stress. Although recent studies have, in great detail, explored the role of antioxidants in lung and skin tumors driven by RAS and RAF mutations, little is known about the impact of antioxidant supplementation on other cancers, including Wnt-driven tumors originating from the gut. Here, we show that supplementation with the antioxidants N-acetylcysteine (NAC) and vitamin E promotes intestinal tumor progression in the ApcMin mouse model for familial adenomatous polyposis, a hereditary form of colorectal cancer, driven by Wnt signaling. Both antioxidants increased tumor size in early neoplasias and tumor grades in more advanced lesions without any impact on tumor initiation. Importantly, NAC treatment accelerated tumor progression at plasma concentrations comparable to those obtained in human subjects after prescription doses of the drug. These results demonstrate that antioxidants play an important role in the progression of intestinal tumors, which may have implications for patients with or predisposed to colorectal cancer.
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  • Özger, Mustafa, et al. (författare)
  • Energy-Efficient Transmission Range and Duration for Cognitive Radio Sensor Networks
  • 2021
  • Ingår i: IEEE Transactions on Cognitive Communications and Networking. - : Institute of Electrical and Electronics Engineers (IEEE). - 2332-7731. ; , s. 1-1
  • Tidskriftsartikel (refereegranskat)abstract
    • Cognitive Radio (CR) promises an efficient utilization of radio spectrum resources by enabling dynamic spectrum access to overcome the spectrum scarcity problem. Cognitive Radio Sensor Networks (CRSNs) are one type of Wireless Sensor Networks (WSNs) equipped with CR capabilities. CRSN nodes need to operate energy-efficiently to extend network lifetime due to their limited battery capacity. In this paper, for the first time in literature, we formulate the problem of finding a common energy-efficient transmission range and transmission duration for all CRSN nodes and network deployment that would minimize the energy consumed per goodput per meter toward the sink in a greedy forwarding scenario. Results reveal non-trivial relations for energy-efficient CRSN transmission range and duration as a function of nine critical network parameters such as primary user activity levels. These relations provide valuable insights for detailed CRSN designs prior to deployment.
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  • Resultat 1-7 av 7

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