| 1. |
- Owiredu, Maria, 1982-
(författare)
-
Sveriges politiska partier och Israel-Palestinafrågan : En analys av svenska partiers agerande 2006–2021
- 2024
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis studies political parties in Sweden and their attitudes toward the Israel-Palestine issue during the period from 2006-2021. The analysis assumes that political parties act strategically, guided by their party goals across different arenas: parliamentary, internal, and electoral. Five key party goals—policy, vote-seeking, position, party cohesion, and international credibility—are used to analyze the strategic behavior of these parties. The Israel-Palestine issue holds strategic relevance for several political parties. Left-leaning parties (such as the Green Party, Social Democrats, and Left Party) benefit the most from strategically engaging with this issue. Even parties like the Christian Democrats and the Liberal Party recognize strategic relevance in addressing the Israel-Palestine issue. Notably, the Center Party påsy the least attention to this issue. The most relevant party goals are policy and international credibility. The study also reveals significant relationships between parties and their sympathizers. In addition, the results offer concrete examples of how the party strategy works within the political parties, thus contributing to party strategy research, Swedish foreign policy and the Israel-Palestine issue in a Swedish context. In conclusion, the Israel-Palestine issue is deeply ideological. While it serves as a political tool in foreign policy debates, its impact is even more pronounced in domestic discussions, where parties use it to underscore their ideological stances. Overall, the Israel-Palestine issue remains to be one of the most polarized topics in the Swedish foreign policy debate.
|
|
| 2. |
- Persson, Anders, 1982-, et al.
(författare)
-
Why Is Sweden Shifting Towards Right-wing Israel
- 2023
-
Ingår i: Haaretz. - : Haaretz Daily Newspaper Ltd.. ; :Sept 27
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- When a delegation from Sweden's ruling party met withNetanyahu recently, it was all broad smiles and handshakes - afar cry from Stockholm's famed criticism of Israel. What haschanged - and why?
|
|
| 3. |
- Berglund, Martin, 1985-, et al.
(författare)
-
Extreme-temperature lab on a chip for optogalvanic spectroscopy of ultra small samples – key components and a first integration attempt
- 2016
-
Ingår i: 27th Micromechanics And Microsystems Europe Workshop (MME 2016). - : Institute of Physics (IOP).
-
Konferensbidrag (refereegranskat)abstract
- This is a short summary of the authors’ recent R&D on valves, combustors, plasma sources, and pressure and temperature sensors, realized in high-temperature co-fired ceramics, and an account for the first attempt to monolithically integrate them to form a lab on a chip for sample administration, preparation and analysis, as a stage in optogalvanic spectroscopy.
|
|
| 4. |
- Echeverri Correa, Estefania, et al.
(författare)
-
Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels
- 2023
-
Ingår i: Biomaterials Science. - : Royal Society of Medicine Press. - 2047-4830 .- 2047-4849. ; 11:9, s. 3144-3158
-
Tidskriftsartikel (refereegranskat)abstract
- Silicon nitride (SiN) coatings may reduce unwanted release of metal ions from metallic implants. However, as SiN slowly dissolves in aqueous solutions, additives that reduce this dissolution rate would likely increase the lifetime and functionality of implants. Adding iron (Fe) and carbon (C) permits tuning of the SiN coatings’ mechanical properties, but their effect on SiN dissolution rates, and their capacity to reduce metal ion release from metallic implant substrates, have yet to be investigated. Such coatings have recently been proposed for use in spinal implants; therefore, it is relevant to assess their impact on the viability of cells expected at the implant site, such as microglia, the resident macrophages of the central nervous system (CNS). To study the effects of Fe and C on the dissolution rate of SiN coatings, compositional gradients of Si, Fe and C in combination with N were generated by physical vapor deposition onto CoCrMo discs. Differences in composition did not affect the surface roughness or the release of Si, Fe or Co ions (the latter from the CoCrMo substrate). Adding Fe and C reduced ion release compared to a SiN reference coating, which was attributed to altered reactivity due to an increase in the fraction of stabilizing Si–C or Fe–C bonds. Extracts from the SiN coatings containing Fe and C were compatible with microglial viability in 2D cultures and 3D collagen hydrogels, to a similar degree as CoCrMo and SiN coated CoCrMo reference extracts. As Fe and C reduced the dissolution rate of SiN-coatings and did not compromise microglial viability, the capacity of these additives to extend the lifetime and functionality of SiN-coated metallic implants warrants further investigation.
|
|
| 5. |
- Echeverri Correa, Estefania, et al.
(författare)
-
Reducing the dissolution rate of silicon nitride coatings for spinal implants using Fe and C as alloying elements
- 2023
-
Konferensbidrag (refereegranskat)abstract
- INTRODUCTION: Wear and corrosion may lead to a release of particles and ions from spinal implants, which is a concern because of their potentially detrimental effect on the life span of the implant [1]. Silicon nitride-based coatings have been suggested as an option to reduce the release of metal ions from an implant. In addition, any particles produced will slowly dissolve, releasing only biocompatible ions [2]. It is of high interest to reduce the dissolution rate of the coating to ensure an adequate lifetime [3]. The present study aimed to assess the effect of Fe and C additions to silicon nitride coatings in terms of dissolution rate as well as the impact of the released ions on the in vitro neural cell response.METHODS: Using a combinatorial approach, SiFeCN coatings were deposited on CoCr disc substrates by reactive sputtering in an in-house built equipment. The coatings were characterized in 9 points using x-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). The dissolution behaviour was evaluated by exposing the coated samples to cell media for 14 days. The obtained extracts were used to measure ion release with inductively coupled plasma - optical emission spectrometry (ICP-OES) and to assess cell viability of microglia (C8-B4 cell line) using the MTT assay. RESULTS: The XPS results showed compositional gradients of Si ranging from 35.0 to 47.3 at.%, Fe from 1.4 to 9.3 at.% and C from 4.5 to 13.9 at.%. SEM of focused ion beam (FIB) cross-sections revealed coating thicknesses between 427-534 nm. SEM of the coating after exposure showed substantial signs of dissolution with visibly increased porosity for the SiN coating, while the SiFeCN coatings appeared less affected. SiFeCN coatings appeared more affected by dissolution for increasing Si contents. The estimated dissolution rate of the SiN coating was 8.3 nm/day, while the rate of SiFeCN coatings was 5.2-6.8 nm/day. The ICP results showed a reduction in Co ions from the substrate in the coated samples compared to uncoated CoCr. Moreover, the levels of detected Si ions were lower for the SiFeCN compared to SiN reference. Indirect biocompatibility tests suggested that microglia cell viability was comparable for the SiFeCN coatings, the uncoated CoCr and the SiN coating.DISCUSSION & CONCLUSIONS: The compositional gradients influenced the thickness of the coating, giving a slight thickness increase in the coatings with the increment of Si content. In addition, the ICP results showed the capability of the coating to act as a barrier to the release of ions from the substrate. Furthermore, the presence of Fe and C in the coating causes a decrease in the ion release from the coating, indicative of a lower dissolution rate, which was supported by the thickness measurements. The findings from this study indicate that using Fe and C as alloying elements can lower the dissolution rate of the silicon nitride-based coating while showing positive indications of biocompatibility on neural cells. Therefore, SiFeCN coatings merit further investigation as a future option for spinal implants.REFERENCES: 1Y. Shimamura et al (2008) Spine. 33:351–355. 2M. Pettersson et al (2016) ACS Biomater. Sci. Eng. 2:998–1004. 3C. Skjöldebrand et al (2022) Biomater Sci, 10:3757–3769.ACKNOWLEDGEMENTS: This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 812765 and from the European Union’s Seventh Framework Programme (FP7/2007-2013), grant agreement GA-310477(LifeLongJoints).
|
|
| 6. |
|
|
| 7. |
- Gupta, Vikas, et al.
(författare)
-
Automated three-dimensional tracking of the left ventricular myocardium in time-resolved and dose-modulated cardiac CT images using deformable image registration
- 2018
-
Ingår i: Journal of Cardiovascular Computed Tomography. - : Elsevier. - 1934-5925. ; 12:2, s. 139-148
-
Tidskriftsartikel (refereegranskat)abstract
- Background Assessment of myocardial deformation from time-resolved cardiac computed tomography (4D CT) would augment the already available functional information from such an examination without incurring any additional costs. A deformable image registration (DIR) based approach is proposed to allow fast and automatic myocardial tracking in clinical 4D CT images.Methods Left ventricular myocardial tissue displacement through a cardiac cycle was tracked using a B-spline transformation based DIR. Gradient of such displacements allowed Lagrangian strain estimation with respect to end-diastole in clinical 4D CT data from ten subjects with suspected coronary artery disease. Dice similarity coefficient (DSC), point-to-curve error (PTC), and tracking error were used to assess the tracking accuracy. Wilcoxon signed rank test provided significance of tracking errors. Topology preservation was verified using Jacobian of the deformation. Reliability of estimated strains and torsion (normalized twist angle) was tested in subjects with normal function by comparing them with normal strain in the literature.Results Comparison with manual tracking showed high accuracy (DSC: 0.99± 0.05; PTC: 0.56mm± 0.47 mm) and resulted in determinant(Jacobian) > 0 for all subjects, indicating preservation of topology. Average radial (0.13 mm), angular (0.64) and longitudinal (0.10 mm) tracking errors for the entire cohort were not significant (p > 0.9). For patients with normal function, average strain [circumferential, radial, longitudinal] and peak torsion estimates were: [-23.5%, 31.1%, −17.2%] and 7.22°, respectively. These estimates were in conformity with the reported normal ranges in the existing literature.Conclusions Accurate wall deformation tracking and subsequent strain estimation are feasible with the proposed method using only routine time-resolved 3D cardiac CT.
|
|
| 8. |
- Jiang, Yiwen, 1982-
(författare)
-
Interplay Between Cell of Origin and Oncogenic Activation in Glioma
- 2012
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Glioma is the most frequent primary tumor of the central nervous system. By using the RCAS/tv-a mouse glioma model, we have studied mechanisms controlling glioma development and the effect of cell of origin on these processes.SOX5 was identified as a brain tumor locus in a retroviral insertional mutagenesis screen of PDGF-B induced mouse gliomas. Here we found that SOX5 could suppress PDGFB-induced glioma development particularly in Ink4a-/- mice. Analysis of putative PDGF-B signaling pathways revealed that the underlying mechanism could involve the activation of AKT and p27, which caused an acute cellular senescence.When cultured in a highly selective serum free medium, glioma-initiating cells could be isolated from mouse GBMs and their self-renewal and proliferation was independent on exogenous EGF and FGF2. Addition of serum into the medium induced aberrant differentiation that was reversible. Specific depletion of viral PDGF-B demonstrated that PDGF-B was necessary for stemness and tumorigenicity of GICs by preventing them to differentiate.Subsequently, by applying the same culture conditions, GICs of APC, NSC and OPC origins were isolated from mouse GBMs. GICs derived from NSCs exhibited higher self-renewal, faster proliferation and more potent tumorigenicity than those of APC or OPC origin. Furthermore, addition of 5% serum significantly inhibited the proliferation of APC- and OPC-derived GICs, but did not in NSC-derived GICs. Transcriptome analysis revealed that GICs of the same cell of origin displayed distinct expression profiles.In the last study, we showed that OPCs could serve as the origin for astrocytic glioma. Results from immunostainings revealed that these tumors might belong to a different molecular subtype than the oligodendroglial tumors induced in OPCs. We also found differences in tumorigenic potential between OPCs in neonatal and adult mice, which suggest that developmental age of the cell of origin is important for its susceptibility to oncogenic transformation.
|
|
| 9. |
- Klintberg, Lena, et al.
(författare)
-
Partial least squares modelling of spectroscopic data from microplasma emissions for determination of CO2 concentration
- 2020
-
Ingår i: Plasma Research Express. - : IOP Publishing. - 2516-1067. ; 2:4
-
Tidskriftsartikel (refereegranskat)abstract
- The spectral emissions from a microplasma have been used to predict the CO2 concentration in gas samples covering a concentration range of 0%–100%. Different models based on partial least squares have been evaluated, comparing two different spectral pre-processing filters – multiplicative scatter correction (MSC) and standard normal variate correction (SNV) – and three different wavelength ranges. The models were compared with respect to accuracy, precision, stability and linearity. CO2 samples were mixed with either air or nitrogen. The choice of mixing gas influenced the predicted concentration and basing the models on data from only one mixing gas resulted in higher prediction power. Using air as mixing gas and SNV filtering resulted in a root mean square error of prediction (RMSEP) of 0.03 for an independent test dataset. This RMSEP was of the same range as the experimental error. On the other hand, the models with the best long term stability, reaching the lowest Allan variance, were based on observations with both mixing gases. Models based on MSC filtering generally had slightly higher RMSEP than those based on SNV filtering. Generally, the CO2 concentration could be accurately predicted in the concentration range of 5%–90%. For higher and lower concentrations, the models underestimated the CO2 concentration and were less accurate and precise. Basing the models on fewer wavelengths resulted in reduced linearity. The models were also evaluated by applying them for transcutaneous blood gas monitoring, where they helped to reveal new physiological information.
|
|
| 10. |
- Lantz, Jonas, 1982-, et al.
(författare)
-
Impact of prosthetic mitral valve orientation on the ventricular flow field : Comparison using patient-specific computational fluid dynamics
- 2021
-
Ingår i: Journal of Biomechanics. - : Elsevier Science Ltd. - 0021-9290 .- 1873-2380. ; 116
-
Tidskriftsartikel (refereegranskat)abstract
- Significant mitral valve regurgitation creates progressive adverse remodeling of the left ventricle (LV). Replacement of the failing valve with a prosthesis generally improves patient outcomes but leaves the patient with non-physiological intracardiac flow patterns that might contribute to their future risk of thrombus formation and embolism. It has been suggested that the angular orientation of the implanted valve might modify the postoperative distortion of the intraventricular flow field. In this study, we investigated the effect of prosthetic valve orientation on LV flow patterns by using heart geometry from a patient with LV dysfunction and a competent native mitral valve to calculate intracardiac flow fields with computational fluid dynamics (CFD). Results were validated using in vivo 4D Flow MRI. The computed flow fields were compared to calculations following virtual implantation of a mechanical heart valve oriented in four different angles to assess the effect of leaflet position. Flow patterns were visualized in longand short-axes and quantified with flow component analysis. In comparison to a native valve, valve implantation increased the proportion of the mitral inflow remaining in the basal region and further increased the residual volume in the apical area. Only slight changes due to valve orientation were observed. Using our numerical framework, we demonstrated quantitative changes in left ventricular blood flow due to prosthetic mitral replacement. This framework may be used to improve design of prosthetic heart valves and implantation procedures to minimize the potential for apical flow stasis, and potentially assist personalized treatment planning. (c) 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
|
|
