| 1. |
- Engström, Gunnar, et al.
(författare)
-
Pulmonary function and atherosclerosis in the general population : causal associations and clinical implications
- 2024
-
Ingår i: European Journal of Epidemiology. - : Springer Nature. - 0393-2990 .- 1573-7284. ; 39:1, s. 35-49
-
Tidskriftsartikel (refereegranskat)abstract
- Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50–64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.
|
|
| 2. |
|
|
| 3. |
- Blix, Mårten, et al.
(författare)
-
Tid att följa upp : Digital tidmätning i svensk hemtjänst
- 2023
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Digitala tidmätningssystem används i svensk hemtjänst för att mäta och följa upp hemtjänstbesökens längd och innehåll. Systemen samlar in data i realtid och om alla besök. I detta avseende är digital tidmätning ett kraftfullt verktyg som kan förväntas ge bättre förutsättningar för mål-och resultatstyrning än analoga metoder. Samtidigt innebär tidmätningen risker för arbetsmiljön då den kan uppfattas som detaljstyrande och stressande. I denna rapport presenterar vi resultaten från en enkät som skickades ut till alla kommuner om deras användande av tidmätningssystem i hemtjänsten. 123 kommuner besvarade enkäten och 94 av dessa angav att de mäter tidsanvändningen med hjälp av digitala system. I denna rapport presenterar och diskuterar vi resultaten från denna enkät.
|
|
| 4. |
- Bråkenhielm, Carl-Reinhold
(bidragsgivare, creator_code:cre_t)
-
Kunskapsläget på kärnavfallsområdet 2022 : Samhället, tekniken och etiken
- 2022
-
Rapport (populärvet., debatt m.m.)abstract
- Kärnavfallsrådet (Statens råd för kärnavfallsfrågor) är en tvärvetenskaplig kommitté som har i uppdrag att ge regeringen råd i frågor om använt kärnbränsle, kärnavfall och rivning av kärntekniska anläggningar, (M 1992:A Kärnavfallsrådet. Dir. 2018:18). I februari vartannat år ger Kärnavfallsrådet sin självständiga bedömning av det aktuella läget inom kärnavfallsområdet. Bedömningen presenteras i form av en kunskapslägesrapport. Syftet med rapporten är att upp-märksamma och beskriva frågor som Kärnavfallsrådet anser viktiga och att redogöra för rådets synpunkter i dessa. Kärnavfallsrådet överlämnar härmed till regeringen årets kunskapslägesrapport SOU 2022:7 Kunskapsläget på kärnavfallsområdet 2022 – Samhället, tekniken och etiken.Bakom denna rapport står samtliga ledamöter och sakkunniga i Kärnavfallsrådet. Kärnavfallsrådets vetenskapliga sekreterare Johanna Swedin har varit projektledare för arbetet med kunskapslägesrapporten.Rapporterna om kunskapsläget på kärnavfallsområdet åren 1998, 2001, 2004, 2007, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018 och 2020 finns även tillgängliga i en engelsk version. Rådet kommer att publicera en engelsk översättning av årets rapport under våren 2022.
|
|
| 5. |
- Börjesson, Peter, 1980, et al.
(författare)
-
The Merits of Situated Evaluation as an Alternative UX Evaluation Method to Understand Appropriation
- 2018
-
Ingår i: Interaction Design and Architecture(s). - 2283-2998 .- 1826-9745. ; :37, s. 78-98
-
Tidskriftsartikel (refereegranskat)abstract
- Oftentimes, technologies are not used in the ways designers had initially envisioned. Instead, people adapt technologies to their own needs, a phenomenon called ‘appropriation’. Appropriation is an important aspect of User Experience design, related to the situatedness and dynamics of the design, recognizing not only that initial needs and requirements may change over time, but also that a design may change the environment that it was designed for. Appropriation can also contribute to a sense of ownership as people use a design in their own way, sometimes in ways the designer did not intend. However, commonly used User Experience evaluation methods often do not focus on the appropriation process of a technology. Situated Evaluation is an approach that does focus on appropriation, although it has not yet been used extensively in the UX field. In this paper, we therefore present and critically discuss our use of the Situated Evaluation approach for the evaluation of a specific tool that aims to enhance the communication between children, parents, and teaching staff in special education. By presenting this case, we hope to inform other UX researchers and designer about the potential of the approach to understand appropriation is an important factor in UX design.
|
|
| 6. |
- Davidsson, Pia, 1962, et al.
(författare)
-
Clinical mass spectrometry in neuroscience. Proteomics and peptidomics.
- 2003
-
Ingår i: Cellular and molecular biology (Noisy-le-Grand, France). - 0145-5680 .- 1165-158X. ; 49:5, s. 681-8
-
Forskningsöversikt (refereegranskat)abstract
- In this review we discuss the merits and drawbacks with the use of proteomic and peptidomic strategies for identification of proteins and peptides in their multidimensional interactions in complex biological processes. The progress in proteomics and peptidomics during the last years offer us new challenges to study changes in the protein and peptide synthesis. These strategies also offer new tools to follow post-translational modifications and other disturbed chemical processes that may be indicative of pathophysiological alteration(s). Furthermore these techniques can contribute to improvements in the diagnosis and therapy of neurodegenerative diseases, such as Alzheimer's disease, and psychiatric diseases, as depression and post traumatic stress disorders. We also consider different practical aspects of the applications of mass spectrometry in clinical neuroscience, illustrated by example from our laboratories. The new proteomic and peptidomic strategies will further enable the progress for clinical neuroscience research.
|
|
| 7. |
- Hietala, Max Albert, 1969, et al.
(författare)
-
Complement activation by both classical and alternative pathways is critical for the effector phase of arthritis.
- 2004
-
Ingår i: European journal of immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 34:4, s. 1208-16
-
Tidskriftsartikel (refereegranskat)abstract
- To analyze the role of the classical and alternative pathways of complement activation in the effector phase of arthritis, we have induced arthritis in C3- and factor B (FB)-deficient (C3(-/-) and FB(-/-)) DBA/1J mice using well-defined monoclonal IgG2b and IgG2a antibodies to type II collagen. In control DBA/1J mice, severe swelling of the joints, destruction of cartilage and erosion of bone developed very rapidly with a 100% incidence and a peak on days 7-10. Although 75% of C3(-/-) mice developed arthritis, the clinical severity was very mild and the onset was delayed. Severity of arthritis in FB(-/-) mice ranked intermediate in comparison with C3(-/-) and control mice with an incidence of 100%. Immunohistochemical analysis of the inflamed joints demonstrated substantial reduction in macrophage and neutrophilic leukocyte infiltration in both C3(-/-) and FB(-/-) mice, thereby confirming the clinical findings. We conclude that both the classical and the alternative pathways of complement activation are involved in the effector phase of arthritis.
|
|
| 8. |
- Jordahl, Henrik, 1971-, et al.
(författare)
-
Time tracking in home care : Perceptions and reality
- 2023
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- We examine the implementation of digital time tracking in home care services in Swedish municipalities. Our study combines original survey data with external measures of quality and costs, allowing us to examine both the perceived and estimated effects of time tracking. According to the responding managers, time tracking has led to improvements in quality and reductions in costs. However, the estimated effects suggest that these managerial perceptions may need to be revised. We found that quality is unaffected or reduced while costs have increased due to the implementation of time tracking.
|
|
| 9. |
- Karlsson, Linda, et al.
(författare)
-
Atomically Resolved Structural and Chemical Investigation of Single MXene Sheets
- 2015
-
Ingår i: Nano letters (Print). - : American Chemical Society (ACS). - 1530-6984 .- 1530-6992. ; 15:8, s. 4955-4960
-
Tidskriftsartikel (refereegranskat)abstract
- The properties of two-dimensional (2D) materials depend strongly on the chemical and electrochemical activity of their surfaces. MXene, one of the most recent additions to 2D materials, shows great promise as an energy storage material. In the present investigation, the chemical and structural properties of individual Ti3C2 MXene sheets with associated surface groups are investigated at the atomic level by aberration corrected STEM-EELS. The MXene sheets are shown to exhibit a nonuniform coverage of O-based surface groups which locally affect the chemistry. Additionally, native point defects which are proposed to affect the local surface chemistry, such as oxidized titanium adatoms (TiOx), are identified and found to be mobile.
|
|
| 10. |
- Lindström, L, et al.
(författare)
-
Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia.
- 2005
-
Ingår i: Schizophrenia research. - : Elsevier BV. - 0920-9964 .- 1573-2509. ; 80:2-3, s. 315-22
-
Tidskriftsartikel (refereegranskat)abstract
- Previous studies have shown that endogenous brain levels of kynurenic acid (KYNA), a glutamate receptor antagonist, are elevated in patients with schizophrenia. Here we analyse KYNA in the cerebrospinal fluid (CSF) from a large cohort, including male healthy controls (n=49) and male patients with schizophrenia (n=90). We found that male patients with schizophrenia had significantly higher levels of CSF KYNA compared to healthy male controls (1.45 nM+/-0.10 vs. 1.06 nM+/-0.06 in the control group). Furthermore, when the patients with schizophrenia were divided into subgroups we found that CSF KYNA levels were significantly elevated in drug-naïve, first episode patients (1.53 nM+/-0.19, n=37) and in patients undergoing treatment with antipsychotic drugs (1.53 nM+/-0.17, n=34) compared to healthy male controls. No elevated CSF KYNA levels were detected in drug-free patients with schizophrenia, i.e. patients previously undergoing antipsychotic medications but drug-free at time of sampling (1.16 nM+/-0.10, n=19). Present results confirm that CSF KYNA concentration is elevated in patients with schizophrenia and are consistent with the hypothesis that KYNA contributes to the pathophysiology of the disease.
|
|
