| 1. |
- Ceberg, Crister, et al.
(författare)
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Performance of sulfhydryl boron hydride in patients with grade III and IV astrocytoma: a basis for boron neutron capture therapy
- 1995
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Ingår i: Journal of Neurosurgery. - 0022-3085. ; 83:1, s. 79-85
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Tidskriftsartikel (refereegranskat)abstract
- This study investigated the rationale of boron neutron capture therapy (BNCT) for the treatment of Grade III and IV astrocytoma. The European Community joint research program on BNCT plans to use sulfhydryl boron hydride (BSH) in clinical trials. The work presented here, examines the performance of BSH in eight patients with Grade III and IV astrocytoma using a measurement technique which precisely correlates the boron uptake with the histology of the tumor and the peritumoral brain. Astrocytomas are exceptionally heterogeneous and spread migrating tumor cells into the surrounding brain. The patients were infused with 50 mg BSH per kilogram of body weight at 12, 18, 24 or 48 hours before surgery. At the time of operation, specimens were obtained of the tumor, skin, muscle, dura, blood, urine, and, when surgically possible, the brain adjacent to tumor. In three patients the intracellular boron distribution was investigated by subcellular fractionation. The blood clearance was biphasic with half-lives of 0.6 and 8.2 hours. After 3 days, approximately 70% of the dose injected was excreted in the urine. The maximum boron concentration in the tumor was 20 ppm, 12 hours after the infusion. The tumor-to-blood ratios ranged between 0.2 and 1.4, with the highest values after 18 to 24 hours. In the brain specimens the boron concentration never exceeded 1 ppm. This work confirms a selective uptake of boron in the tumor compared to the surrounding brain and that boron, to some extent, is incorporated in the tumor cells.
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| 4. |
- Persson, Emma, 1981-, et al.
(författare)
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Effect of type 1 diabetes on school performance in a dynamic world : new analysis exploring Swedish register data
- 2019
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Ingår i: Applied Economics. - : Taylor & Francis Group. - 0003-6846 .- 1466-4283. ; 51:24, s. 2606-2622
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Tidskriftsartikel (refereegranskat)abstract
- This paper investigates if the effect of type 1 diabetes mellitus (T1DM) on school performance, documented in prior research, has changed in more recent birth cohorts of children using national Swedish population register data. The issue is of interest because management and treatment of the disease have improved over the last decades and, furthermore, because of changes in the educational grading system. Despite these changes, data indicate a persistent negative effect of T1DM on compulsory and upper secondary school grades with a standardized effect size of −0.109 and −0.070, respectively, and the results appear only marginally smaller compared to earlier findings in cohorts completing school under the previous grading system. Moreover, the results are consistent for alternative model specifications and econometric estimation strategies. Whereas access to new treatment technologies and improved diabetes management strategies has reduced the burden of diabetes in daily life, the results from this study indicate that continued efforts are needed to improve the situation in school for children with T1DM to prevent potential long-term socio-economic consequences.
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| 5. |
- Persson, Emma, et al.
(författare)
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Effect of Type 1 Diabetes on School Performance in a Dynamic World : New Analysis Exploring Swedish Register Data
- 2016
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- This paper investigates if the effect of type 1 diabetes mellitus (T1DM) on school performance has changed over time using national Swedish population register data. The issue is of interest because management and treatment of the disease have improved over the last decades and, furthermore, because of changes in the educational grading system. Despite these changes, data indicate a persistent negative effect of T1DM on compulsory and upper secondary school grades and the results appears similar to earlier findings on cohorts completing school under the previous grading system. Moreover, the results are robust to alternative model specifications and econometric estimation strategies. Whereas access to new treatment technologies and improved diabetes management strategies has reduced the burden of diabetes in daily life, the results from this study indicate that other trends have not implied a reduction, over time, in the impact of T1DM on school performance. This finding indicates that continued efforts are needed to improve the situation in school for children with T1DM to prevent potential long-term socioeconomic consequences.
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| 6. |
- Andersson, Emelie, et al.
(författare)
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Costs of diabetes complications : hospital-based care and absence from work for 392,200 people with type 2 diabetes and matched control participants in Sweden
- 2020
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Ingår i: Diabetologia. - : Springer. - 0012-186X .- 1432-0428. ; 63:12, s. 2582-2594
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Tidskriftsartikel (refereegranskat)abstract
- AIMS/HYPOTHESIS: The risk of complications and medical consequences of type 2 diabetes are well known. Hospital costs have been identified as a key driver of total costs in studies of the economic burden of type 2 diabetes. Less evidence has been generated on the impact of individual diabetic complications on the overall societal burden. The objective of this study was to analyse costs of hospital-based healthcare (inpatient and outpatient care) and work absence related to individual macrovascular and microvascular complications of type 2 diabetes in Sweden in 2016.METHODS: Data for 2016 were retrieved from a Swedish national retrospective observational database cross-linking individual-level data for 1997-2016. The database contained information from population-based health, social insurance and socioeconomic registers for 392,200 people with type 2 diabetes and matched control participants (5:1). Presence of type 2 diabetes and of diabetes complications were derived using all years, 1997-2016. Costs of hospital-based care and of absence from work due to diabetes complications were estimated for the year 2016. Regression analysis was used for comparison with control participants to attribute absence from work to individual complications, and to account for joint presence of complications.RESULTS: Use of hospital care for complications was higher in type 2 diabetes compared with control participants in 2016: 26% vs 12% had ≥1 hospital contact; there were 86,104 vs 24,608 outpatient visits per 100,000 people; and there were 9894 vs 2546 inpatient admissions per 100,000 people (all p < 0.001). The corresponding total costs of hospital-based care for complications were €919 vs €232 per person (p < 0.001), and 74.7% of costs were then directly attributed to diabetes (€687 per person). Regression analyses distributed the costs of days absent from work across diabetes complications per se, basic type 2 diabetes effect and unattributed causes. Diabetes complications amounted to €1317 per person in 2016, accounting for possible complex interactions (25% of total costs of days absent). Key drivers of costs were the macrovascular complications angina pectoris, heart failure and stroke; and the microvascular complications eye diseases, including retinopathy, kidney disease and neuropathy. Early mortality in working ages cost an additional €579 per person and medications used in risk-factor treatment amounted to €418 per person.CONCLUSIONS/INTERPRETATION: The economic burden of complications in type 2 diabetes is substantial. Costs of absence from work in this study were found to be greater than of hospital-based care, highlighting the need for considering treatment consequences in a societal perspective in research and policy. Graphical abstract.
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| 7. |
- Andersson, Helene, 1983, et al.
(författare)
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The influence of the molecular weight of the water-soluble polymer on phase-separated films for controlled release
- 2016
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Ingår i: International Journal of Pharmaceutics. - : Elsevier BV. - 0378-5173 .- 1873-3476. ; 511:1, s. 223-235
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Tidskriftsartikel (refereegranskat)abstract
- Hydroxypropyl cellulose (HPC) and ethyl cellulose (EC) can be used for extended release coatings, where the water-soluble HPC may act as a pore former. The aim was to investigate the effect of the molecular weight of HPC on the microstructure and mass transport in phase-separated freestanding EC/HPC films with 30% w/w HPC. Four different HPC grades were used, with weight averaged molecular weights (Mw) of 30.0 (SSL), 55.0 (SL), 83.5 (L) and 365 (M) kg/mol. Results showed that the phase-separated structure changed from HPC-discontinuous to bicontinuous with increasing Mw of HPC. The film with the lowest Mw HPC (SSL) had unconnected oval-shaped HPC-rich domains, leaked almost no HPC and had the lowest water permeability. The remaining higher Mw films had connected complex-shaped pores, which resulted in higher permeabilities. The highest Mw film (M) had the smallest pores and very slow HPC leakage, which led to a slow increase in permeability. Films with grade L and SL released most of their HPC, yet the permeability of the L film was three times higher due to greater pore connectivity. It was concluded that the phase-separated microstructure, the level of pore percolation and the leakage rate of HPC will be affected by the choice of HPC Mw grade used in the film and this will in turn have strong impact on the film permeability.
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| 8. |
- Asklund, Helen, 1975-, et al.
(författare)
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Hästflickan i rörelse : Generationsberättelser om hästboksläsning
- 2023
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Hästflickan i rörelse: Generationsberättelser om hästboksläsningI vår forskning om hästböcker har vi kommit att intressera oss också för hästboksläsarna. I syfte att få kunskap om varför människor läser hästböcker har vi intervjuat cirka 60 unga och vuxna. Ett delresultat utifrån intervjuer med flickor 9-12 och i vissa fall deras (ibland hästintresserade) föräldrar presenteras. Där framkommer att flickorna i många fall är bokslukare, om än tämligen genretrogna. Ett tydligt samband mellan identiteten som hästtjej och läsare framträder, då läsningen ofta har spin-off-effekter på lekmönster. Orsakerna bakom hästboksläsningen handlar om identifikation i termer av ett flickskap som i stallkulturen står utanför normen och som präglas av mod och beslutsamhet, men där även spänning och kunskapsinhämtning nämns. Hästbokens status har höjts i både skolan och på bibliotek, där den tidigare har haft dåligt rykte, något som kan ses som att större uppmärksamhet ägnas åt något som intresserar många flickor.
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| 9. |
- Asklund, Helen, 1975-, et al.
(författare)
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Intersectional Perspectives on Horse Stories : Pia Hagmar’s Series on Millan
- 2021
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Ingår i: Book of Abstracts: Equine Cultures in Transition Conference. ; , s. 3-3
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Konferensbidrag (refereegranskat)abstract
- This paper focuses on horse stories as depictions of identity formation withinequestrian cultures. The material used is Pia Hagmar’s three books on Millan,published 2012-2014. In these stories, the construction of girlhood interconnectswith the becoming of a person used to handle the large and potentially dangerousanimal, which is the horse. In Susanna Hedenborg´s study of the horse story genre(2013), she shows the image of a non-traditional girl, used to hard and dirty work,but also a classical fearful and shy girl outside of the interaction with horses. InHelen Asklund’s study, the investigation uncovers a construction of girlhood incontrast with antagonistic characters (Asklund 2013). This paper uses anintersectional perspective to explore how the main characters in Pia Hagmar’sseries about Millan and their identities are shaped by their interaction with bothhorses and fellow humans of both sexes within equine cultures, a milieu whichallows re-negotiations of what being a girl implies. Adults are positively portrayedas caring providers of knowledge about horses or as facilitators of the ridinginterest through financial support, or negatively as dysfunctional persons unable toact as adults. Boys of similar age and with an interest in horses are portrayed asgood friends, sometimes more, but the girls are, first and foremost, interested inhorses. Between girl characters, there are often conflicts and jealousy. The studyaims at mapping out the formation of identity by highlighting power asymmetriessuch as gender, age, species, class and sexuality.
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| 10. |
- Asklund, Helen, 1975-, et al.
(författare)
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”När vi rider tillsammans känns hon mer som en kompis än som en mamma” : Modersvariationer i tre hästboksserier av Pia Hagmar
- 2024
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Ingår i: Barnboken. - : The Swedish Institute for Children's Books. - 0347-772X .- 2000-4389. ; 47, s. 1-19
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Tidskriftsartikel (refereegranskat)abstract
- This article analyzes how the horse story setting problematizes the conception of the good mother and normative mothering, by elucidating how the gazes of the young main characters on their mothers function in relation to the notion of the good mother, how this influences the mothering and how the mothering characters challenge this notion. Mothering is seen here as caring practices, which can be performed by people other than mothers. The analysis of three horse story series by Pia Hagmar, the books on Klara (1999–2008), the books on Millan (2012–2014) and the books on Juli (2019–2021), shows that the series depict motherhood and mothering at the intersection between the conception of the good mother and the good horse person. The common denominator is nurturing traits that make personal needs take the back seat – for the traditional good mother to the benefit ofher children, for the good horse person to the benefit of the horse. Hagmar normalizes the presence of several mothering characters in addition to their mothers around the horse girls. Furthermore, these characters, who function as mothering variations, contribute to the creation of a solid caring environment, reducing the demands on mothers who try to be everything to their children. Although the daughters’ views of their mothers are sometimes critical, Hagmar allows the mothers to be imperfect, partly incompetent, or simply women with their own agency, interests and needs outside of motherhood. In addition, a mother-daughter relationship built on a common interest in horses allows for a friendship with a common focus – the horse.
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