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Sökning: WFRF:(Perumal Paul)

  • Resultat 1-3 av 3
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1.
  • Glogowska, Aleksandra, et al. (författare)
  • The cytoplasmic domain of proEGF negatively regulates motility and elastinolytic activity in thyroid carcinoma cells
  • 2008
  • Ingår i: Neoplasia. - : Elsevier BV. - 1522-8002 .- 1476-5586. ; 10:10, s. 1120-1130
  • Tidskriftsartikel (refereegranskat)abstract
    • The intracellular domains of the membrane-anchoring regions of some precursors of epidermal growth factor (EGF) family members have intrinsic biologic activities. We have determined the role of the human proEGF cytoplasmic domain (proEGFcyt) as part of the proEGF transmembrane-anchored region (proEGFctF) in the regulation of motility and elastinolytic invasion in human thyroid cancer cells. We found proEGFctF to act as a negative regulator of motility and elastin matrix penetration and the presence of proEGFcyt or proEGF22.23 resulted in a similar reduction in motility and elastinolytic migration. This activity was counteracted by EGF-induced activation of EGF receptor signaling. Decreased elastinolytic migratory activity in the presence of proEGFctF and proEGFcyt/proEGF22.23 coincided with decreased secretion of elastinolytic procathepsin L. The presence of proEGFctF and proEGFcyt/proEGF22.23 coincided with the specific transcriptional up-regulation of t-SNARE member SNAP25. Treatment with siRNA-SNAP25 resulted in motility and elastin migration being restored to normal levels. Epidermal growth factor treatment down-regulated SNAP25 protein by activating EGF receptor-mediated proteasomal degradation of SNAP25. These data provide first evidence for an important function of the cytoplasmic domain of the human proEGF transmembrane region as a novel suppressor of motility and cathepsin L-mediated elastinolytic invasion in human thyroid carcinoma cells and suggest important clinical implications for EGF-expressing tumors.
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2.
  • Kumaresen, Pavithra Perumal, et al. (författare)
  • Agent-Based Software Testing : A Definition and Systematic Mapping Study
  • 2020
  • Ingår i: Proceedings - Companion of the 2020 IEEE 20th International Conference on Software Quality, Reliability, and Security, QRS-C 2020. - 9781728189154 ; , s. 24-31
  • Konferensbidrag (refereegranskat)abstract
    • The emergence of new technologies in software testing has increased the automation and flexibility of the testing process. The use of agents in software testing is an active research area in which various agent methodologies, architectures, and tools are employed to improve different test problems. Even though research that investigates agents in software testing has been growing, these agent-based techniques should be considered in a broader perspective. In order to provide a comprehensive overview of this research area, which we define as agent-based software testing (ABST), a systematic mapping study has been conducted. This mapping study aims to identify the topics studied within ABST, as well as examine the adopted research methodologies, identify the gaps in the current research and point to directions for future ABST research. Our results suggest that there is an interest in ABST after 1999 that resulted in the development of solutions using reactive, BDI, deliberative and cooperate agent architectures for software testing. In addition, most of the ABST approaches are designed using the JADE framework, have targeted the Java programming language, and are used at system-level testing for functional, non-functional and white-box testing. In regards to regression testing, our results indicate a scarce focus from the ABST perspective.
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3.
  • Niemi, MEK, et al. (författare)
  • 2021
  • swepub:Mat__t
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  • Resultat 1-3 av 3

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