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1.	Egli-Gany, D, et al. (författare) Human papillomavirus genotype distribution and socio-behavioural characteristics in women with cervical pre-cancer and cancer at the start of a human papillomavirus vaccination programme: the CIN3+ plus study 2019 Ingår i: BMC cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 19:1, s. 111- Tidskriftsartikel (refereegranskat)
2.	Petignat, P., et al. (författare) Expression of matrix metalloproteinase-2 and mutant p53 is increased in hydatidiform mole as compared with normal placenta 2006 Ingår i: International Journal of Gynecological Cancer. - : BMJ. - 1048-891X .- 1525-1438. ; 16:4, s. 1679-1684 Tidskriftsartikel (refereegranskat)abstract Matrix metalloproteinases (MMPs) are group of enzymes thought to play an important role in trophoblastic and tumor invasion. The aim of our study was to investigate the trophoblastic expression of MMPs and p53 in normal trophoblast and hydatidiform moles (HM). Paraffin sections of 45 specimens, including 14 complete hydatidiform moles (CM), 15 partial hydatidiform moles (PM), 8 atypical partial hydatidiform moles (aPM), and 8 controls were selected. Classification of HM was established on histologic criteria and supported by the DNA ploidy results. Tissue sections from each case were immunostained with monoclonal antibodies, cytokeratin-7, MMP-2, MMP-9, tissue inhibitors of metalloproteinases (TIMP)-1, and p53 wild type (p53wt) and mutant types (mutp53). Staining for cytokeratin-7 revealed a positive reaction in 93% of the samples. MMP-2 was mainly expressed in the syncytiotrophoblast of HM and found in 62% of aPM, 60% PM, and 93% CM. The mutp53 was mainly and focally expressed in syncytiotrophoblastic cells and was found in 63% of aPM, 80% PM, and 93% CM. Expression of MMP-2 and mutp53 was both significantly greater in HM vs control group (P < 0.05) and greater in CM vs PM and aPM (P < 0.05). No significant difference was observed for cytokeratin-7, MMP-9, TIMP-1, and p53wt between the HM subgroups and between HM and control group. MMP-2 and mutp53 are overexpressed in HM as compared with normal trophoblast and might participate in the invasive behavior of the HM.

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Resultat 1-2 av 2

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Petignat, P (2); Dillner, J (1); Weintraub, D (1); Eklund, C (1); Laurini, Ricardo (1); Rapiti, E (1); visa fler...; Kreis, C (1); Zimmermann, D. (1); Tille, JC (1); Bischof, P. (1); Goffin, F (1); Graber, A (1); Low, N (1); Egli-Gany, D (1); Zographos, AS (1); Diebold, J (1); Spicher, VM (1); Tirri, BF (1); Heusser, R (1); Sahli, R (1); Baege, A (1); Bannwart, F (1); Berlin, C (1); Cassinotti, P (1); Cathomas, G (1); Claass, J (1); Frattini, M (1); Hafliger, A (1); Ho, LZ (1); Kind, A (1); Mazzucchelli, L (1); McKee, T (1); Megevand, E (1); Meyer-Hamme, U (1); Molinari, F (1); Noppen, C (1); Noske, A (1); Raineri, I (1); Rubi, D (1); Rupp, NJ (1); Schwedler, K (1); Stallmach, T (1); Tornillo, L (1); Valera, A (1); Went, P (1); Bruchim, I. (1); visa färre...

Lärosäte: Lunds universitet (1); Karolinska Institutet (1)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (1)

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