| 1. |
- Bauch, Thilo, 1972, et al.
(författare)
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High critical temperature superconductor Josephson junctions for quantum circuit applications
- 2009
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Ingår i: Physica Scripta. ; T137, s. 014006-
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Konferensbidrag (refereegranskat)abstract
- Recent findings of macroscopic quantum properties in high critical temperature superconductor (HTS) Josephson junctions (JJs) point toward the need to revise the role of zero energy quasi-particles in this novel superconductor. We will discuss the possibility of designing superconducting artificial atoms in a transmon configuration to study the low energy excitation spectra of HTS. We have engineered high quality grain boundary JJs on low dielectric constant substrates. By fabricating submicron junctions, we extract values of capacitance and Josephson critical current densities that satisfy the main transmon design requirements. Moreover, the measured critical current noise power extrapolated at 1 Hz gives a dephasing time of 25 ns, which indicates that the observation of macroscopic quantum coherent effects in HTS JJ is a feasible task.
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| 2. |
- Cedergren, Karin, 1975, et al.
(författare)
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Biepitaxial YBa2Cu3O7-x 0-pi Josephson junctions
- 2010
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Ingår i: Superconductor Science and Technology. - : IOP Publishing. - 0953-2048 .- 1361-6668. ; 23:3, s. Article Number: 034027-
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements performed on YBa2Cu3O7-x '0' and '0-pi' Josephson junctions fabricated using the biepitaxial technique with SrTiO3 as substrate and CeO2 as seed layer. Measurements of the critical current as a function of external magnetic field clearly show complementary behavior of the two kinds of junctions. Our results unambiguously show that the d-wave nature of the order parameter dominates the current transport across the junctions despite the faceting on the microscale along the grain boundary line.
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| 3. |
- Devarakonda, Sravani, et al.
(författare)
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Low-grade intestinal inflammation two decades after pelvic radiotherapy.
- 2023
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Ingår i: EBioMedicine. - 2352-3964. ; 94
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Tidskriftsartikel (refereegranskat)abstract
- Radiotherapy is effective in the treatment of cancer but also causes damage to non-cancerous tissue. Pelvic radiotherapy may produce chronic and debilitating bowel symptoms, yet the underlying pathophysiology is still undefined. Most notably, although pelvic radiotherapy causes an acute intestinal inflammation there is no consensus on whether the late-phase pathophysiology contains an inflammatory component or not. To address this knowledge gap, we examined the potential presence of a chronic inflammation in mucosal biopsies from irradiated pelvic cancer survivors.We biopsied 24 cancer survivors two to 20 years after pelvic radiotherapy, and four non-irradiated controls. Using tandem mass tag (TMT) mass spectrometry and mRNA sequencing (mRNA-seq), we charted proteomic and transcriptomic profiles of the mucosal tissue previously exposed to a high or a low/no dose of radiation. Changes in the immune cell populations were determined with flow cytometry. The integrity of the protective mucus layers were determined by permeability analysis and 16S rRNA bacterial detection.942 proteins were differentially expressed in mucosa previously exposed to a high radiation dose compared to a low radiation dose. The data suggested a chronic low-grade inflammation with neutrophil activity, which was confirmed by mRNA-seq and flow cytometry and further supported by findings of a weakened mucus barrier with bacterial infiltration.Our results challenge the idea that pelvic radiotherapy causes an acute intestinal inflammation that either heals or turns fibrotic without progression to chronic inflammation. This provides a rationale for exploring novel strategies to mitigate chronic bowel symptoms in pelvic cancer survivors.This study was supported by the King Gustav V Jubilee Clinic Cancer Foundation (CB), The Adlerbertska Research Foundation (CB), The Swedish Cancer Society (GS), The Swedish State under the ALF agreement (GS and CB), Mary von Sydow's foundation (MA and VP).
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| 4. |
- Albinsson, Bo, 1963, et al.
(författare)
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Electron and energy transfer in donor-acceptor systems with conjugated molecular bridges
- 2007
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Ingår i: Physical Chemistry Chemical Physics. - : Royal Society of Chemistry (RSC). - 1463-9084 .- 1463-9076. ; 9:44, s. 5847-5864
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Tidskriftsartikel (refereegranskat)abstract
- Electron and energy transfer reactions in covalently connected donor-bridge-acceptor assemblies are strongly dependent, not only on the donor-acceptor distance, but also on the electronic structure of the bridge. In this article we describe some well characterised systems where the bridges are π-conjugated chromophores, and where, specifically, the interplay between bridge length and energy plays an important role for the donor-acceptor electronic coupling. For any application that relies on the transport of electrons, for example molecule based solar cells or molecular scale electronics, it will be imperative to predict the electron transfer capabilities of different molecular structures. The potential difficulties with making such predictions and the lack of suitable models are also discussed. © the Owner Societies.
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| 5. |
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| 6. |
- Eriksson, Charli C-G, 1948-, et al.
(författare)
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Academic practice-policy partnerships for health promotion research : experiences from three research programs
- 2014
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Ingår i: Scandinavian Journal of Public Health. - : SAGE Publications. - 1403-4948 .- 1651-1905. ; 42:15 Suppl, s. 88-95
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The development of knowledge for health promotion requires an effective mechanism for collaboration between academics, practitioners, and policymakers. The challenge is better to understand the dynamic and ever-changing context of the researcher-practitioner-policymaker-community relationship.AIMS: The aims were to explore the factors that foster Academic Practice Policy (APP) partnerships, and to systematically and transparently to review three cases.METHODS: Three partnerships were included: Power and Commitment-Alcohol and Drug Prevention by Non-Governmental Organizations in Sweden; Healthy City-Social Inclusion, Urban Governance, and Sustainable Welfare Development; and Empowering Families with Teenagers-Ideals and Reality in Karlskoga and Degerfors. The analysis includes searching for evidence for three hypotheses concerning contextual factors in multi-stakeholder collaboration, and the cumulative effects of partnership synergy.RESULTS: APP partnerships emerge during different phases of research and development. Contextual factors are important; researchers need to be trusted by practitioners and politicians. During planning, it is important to involve the relevant partners. During the implementation phase, time is important. During data collection and capacity building, it is important to have shared objectives for and dialogues about research. Finally, dissemination needs to be integrated into any partnership. The links between process and outcomes in participatory research (PR) can be described by the theory of partnership synergy, which includes consideration of how PR can ensure culturally and logistically appropriate research, enhance recruitment capacity, and generate professional capacity and competence in stakeholder groups. Moreover, there are PR synergies over time.CONCLUSIONS: The fundamentals of a genuine partnership are communication, collaboration, shared visions, and willingness of all stakeholders to learn from one another
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| 7. |
- Hellström, Sara, et al.
(författare)
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A follow up on the feasibility after national implementation of magnesium sulfate for neuroprotection prior to preterm birth.
- 2023
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Ingår i: Acta obstetricia et gynecologica Scandinavica. - : John Wiley & Sons. - 1600-0412 .- 0001-6349. ; 102:12, s. 1741-1748
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Tidskriftsartikel (refereegranskat)abstract
- The risk for brain injury manifested as cerebral palsy is higher in very preterm born children than in term. Prenatal administration of magnesium sulfate (MgSO4 ) has been shown to be neuroprotective and reduces the proportion of very preterm born children later diagnosed with cerebral palsy. A Swedish national clinical practice guideline was implemented in March 2020, stipulating the administration of a single intravenous dose of 6g MgSO4 1-24h prior to delivery before gestational age 32+0, aiming for 90% treatment coverage. The aim of this study was to evaluate the feasibility of this new clinical practice guideline in the first year of its implementation.Data on MgSO4 treatment were collected by reviewing the medical charts of women who gave birth to live born children in gestational age 22+0-31+6 during the period of March 1, 2020 to February 28, 2021, at five Swedish university hospitals. Women with pre-eclampsia, eclampsia, or high elevated liver enzymes low platelets (HELLP) were excluded.A total of 388 women were eligible and 79% received treatment with MgSO4 . Of the 21% not receiving treatment, 9% did not receive treatment due to lack of knowledge about the clinical practice guideline, 9% were not possible to treat and 3% had missing data. The proportion treated increased from 72% to 87% from the first to the last 3months. Of those treated, 81% received the drug within the stipulated timeframe (mean 8.7h, median 3.4h).There was a positive trend over time in the proportion of women receiving MgSO4 treatment, but the a priori target of 90% was not reached during the first year of implementation. Our findings indicate that this target could be reached with additional information to clinicians.
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| 8. |
- Jansson, Anna. K., et al.
(författare)
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Risk and mortality of testicular cancer in patients with neurodevelopmental or other psychiatric disorders
- 2023
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Ingår i: British Journal of Cancer. - : Springer Nature. - 0007-0920 .- 1532-1827. ; 128:12, s. 2261-2269
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundBoth testicular germ cell tumours (TGCT) and neurodevelopmental disorders are associated with urogenital malformations. Few studies have investigated the association between psychiatric disorders and TGCT. We investigated whether history of any psychiatric or neurodevelopmental disorder is associated with increased risk or mortality of TGCT.MethodThis is a nested case-control study including 6166 TGCT patients diagnosed during 1992-2014, individually matched for age and calendar period to 61,660 controls. We calculated odds ratios (ORs) for the association between type of psychiatric diagnoses and TGCT risk. Among the cases, we used a cohort design and calculated hazard ratios (HRs) of the association between psychiatric diagnose and all-cause and TGCT-specific death.ResultsHistory of a neurodevelopmental disorder (attention deficit hyperactivity disorder, autism spectrum disorder and intellectual disabilities) was associated with an increased risk of seminoma (OR: 1.54; 1.09-2.19). Seminoma patients with neurodevelopmental disorders were younger (34 versus 38 years, p = 0.004) and had more stage IV disease (5.4% versus 1.2%) than those without. Psychiatric history overall was not associated with TGCT. Patient history of any psychiatric disorder was associated with an increased all-cause and TGCT-specific death.ConclusionsWe report an association between neurodevelopmental disorders and testicular seminoma, and an increased TGCT-specific mortality for TGCT patients with psychiatric disorders.
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| 9. |
- Ljungdahl, Thomas, 1974, et al.
(författare)
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Geometrically homogeneous series of covalently linked zinc/free-base porphyrin dimers of varying length; design, synthesis and characterization
- 2006
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Ingår i: European Journal of Organic Chemistry. - : Wiley. - 1099-0690 .- 1434-193X. ; :14, s. 3087-3096
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Tidskriftsartikel (refereegranskat)abstract
- Singlet excitation energy transfer, SEET, can be mediated by a bridge, connecting an energy donor and acceptor, via a superexchange mechanism. The mediation efficiency depends on the energy difference between the first excited states of the donor and the bridge, DEDB, as well as the donor-acceptor distance, RDA. We have previously constructed a series of donor-bridge-acceptor, D-B-A, systems that allowed us to study how SEET depends on DEDB. To expand this study into a second dimension, the distance dependence, a new series of D-B-A systems were constructed. This series was based on the same zinc/free-base porphyrin couple as the donor-acceptor pair in the previous series. Their relative orientation was also retained. In contrast to our first series, the bridges in the latter were of varying length. The bridges were oligo(phenyleneethynylene)phenylene (OPE) structures and the length was systematically changed by increasing the no. of phenyleneethynylene units from 1 to 4. To obtain high quality samples, the D-B-A systems were assembled by a building block approach where the zinc and free-base porphyrins were introduced sep. using Heck alkynylations. The performance of the OPE structure as a mediator and scaffold is discussed in terms of singlet excited state energies and flexibility. For the first time, when combining the topical D-B-A systems with our previous subset, a homogeneous series of D-B-A systems has been synthesized that allows for studies of both the distance dependence and the energy difference dependence of SEET.
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| 10. |
- Ljungdahl, Thomas, 1974, et al.
(författare)
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Solvent and base dependence of copper-free palladium-catalyzed cross-couplings between terminal alkynes and arylic iodides: Development of efficient conditions for the construction of gold(III)/free-base porphyrin dimers
- 2006
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Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 71:4, s. 1677-1687
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, our attempts to optimize the Heck alkynylation (copper-free Sonogashira) reaction are presented. An efficient copper-free coupling protocol was needed for the synthesis of gold/zinc porphyrin dimers because previous methods had failed. Previous studies have usually focused on ligands, whereas this work focuses on the choice of solvent and base. The catalytic system throughout the investigation was formed from the stable precursor [Pd-2(dba)(3)center dot CHCl3] together with the ligand triphenylarsine, an easy-to-handle, air-stable ligand. A model study was conducted to examine the dependence of the Heck alkynylation on the solvent and base. The most successful modification proved to be the addition of methanol, as a cosolvent, in combination with a nucleophilic tertiary base. The success of the methanol additive is hypothesized to be caused by the presence of a rate-determining deprotonation step featuring a charge-separated transition state. Finally, the very high yielding and successful synthesis of a series of porphyrin systems using these new conditions is presented. For the first time, gold porphyrin substrates could efficiently be coupled in Heck alkynylation reactions.
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