| 1. |
- Bauer, Fredric, et al.
(författare)
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Mapping GHG emissions and prospects for renewable energy in the chemical industry
- 2023
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Ingår i: Current Opinion in Chemical Engineering. - : Elsevier BV. - 2211-3398. ; 39
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Tidskriftsartikel (refereegranskat)abstract
- Chemicals is the industrial sector with the highest energy demand, using a substantial share of global fossil energy and emitting increasing amounts of greenhouse gasses following rapid growth over the past 25 years. Emissions associated with energy use have increased with growth in coal-dependent regions but are also commonly underestimated in regions with higher shares of renewable energy. Renewable energy is key to reducing greenhouse gas emissions but remains a niche area when considering corporate targets and initiatives aiming at emission reductions, which instead favour incremental energy efficiency improvements. These findings point to a risk for continued lock-in to fossil energy in the industry.
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| 2. |
- Bauer, Fredric, et al.
(författare)
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Petrochemicals and Climate Change : Tracing Globally Growing Emissions and Key Blind Spots in a Fossil-Based Industry
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- With the risk of climate breakdown becoming ever more pressing as the world is on track for 2.7 degrees warming, pressure is increasing on all sectors of the economy to break with fossil fuel dependence and reduce greenhouse gas (GHG) emissions. In this context, the chemical industry and the production of important basic chemicals is a key sector to consider. Although historically a driver of economic development, the sector is highly dependent on fossil resources for use as both feedstock and fuel in the production of as well organic as inorganic chemicals. The chemical industry demands both petroleum fractions and natural gas. Petroleum fractions such as naphtha and petroleum gases are used as feedstocks for building block chemicals and polymers (e.g., benzene and polyethylene), while natural gas is used for methanol and ammonia. Indeed, the sector is associated with both large process emissions as well as energy related emissions. Our results demonstrate that in 2020 direct GHG emissions from the petrochemical sector amounted to 1.8 Gt CO2eq which is equivalent to 4% of global GHG emissions. Indirect GHG emissions resulting from the activities in other industries supplying inputs for the petrochemical industry accounted for another 3.8 Gt CO2eq. The petrochemical industry is thus associated with a total of 5.6Gt CO2eq of GHG emissions, equivalent to ~10% of global emissions. Over the past 25 years, emissions associated with petrochemicals have doubled and the sector is the third most GHG emitting industry. This increase is fueled by large growth of petrochemicals production as well as growth in regions with high indirect emissions, i.e., in energy systems with high dependence on coal and other fossil fuels. Over the past decades, the industry has grown rapidly in the Asia-Pacific region especially in China which in 2020 was the source for about 47% of global GHG emissions associated with petrochemicals. USA accounts for 6% of the emissions from the industry and Europe for 5%. The BRIC group of countries, which except for China also includes Brazil, India, and Russia, currently accounts for 57% of GHG emissions from petrochemicals, showing that the emissions from this sector are more geographically clustered in these countries than emissions from other sectors.Proper disaggregated and comparative analyses of key products is currently not possible. Data confidentiality and a high reliance on proxy data limit the reliability of LCA and stands in the way of mapping climate impacts. A strong demand of chemicals life cycle inventory (LCI) data for environmental footprinting has resulted in a general increase of chemicals data in many LCI databases, but the energy demands both for heat and electricity are typically not well-documented for production processes outside the main bulk chemicals. If incinerated at end-of-life plastics and other chemical products will emit embodied carbon as CO2 and if landfilled there is a risk of slow degradation with associated methane emissions. Global estimates based on most LCA datasets will thus significantly underestimate emissions from the chemical industry.The multitude of value chains dependent on the petrochemical industry makes it an important contribution to life cycle emissions in many sectors of the economy. Petrochemicals are used as an intermediate input in many industries and the emissions associated with them thus propagate through the economy, with final demand in manufacturing industries and services being associated with the largest shares of emissions from chemicals. The impacts and emissions downstream in value chains is however poorly understood and disclosure by petrochemical producers is lacking and insufficient. While disclosure of emissions in the industry has increased over the past decades, it remains partial and shows inconsistencies over time. This is due to issues such as different reporting standards, large discrepancies in the extent of disclosure as well as various other gaps and inconsistencies in reporting. This holds for all scopes, although Scope 1 emissions are better covered. Only some firms disclose information about downstream Scope 3 emissions including end-of-life for final products. Emission targets set by firms in the industry do not correspond to the challenge of large and rapid emission reductions. Many targets include only parts of operations and transparent, standardized target-setting is lacking. Reported emission reduction initiatives to achieve targets are far from sufficient focusing mainly on efficiency improvements or insubstantial parts of the operation. Shifting to renewable energy is a key for rapid emission reductions in the industry, yet few firms report strategic targets for this shift. As the industry has historically been closely linked to and integrated with the energy sector it holds a great potential for engaging with the deployment and adoption of renewable energy, although this implies a transformation of the knowledge base and resource allocation in the industry which is still focused on fossil fuels. Roadmaps and scenario analyses show that apart from a shift to renewable energy, a transformation of the industry relies on the deployment of key technologies which are not yet fully developed. This includes new technologies for hydrogen production, e.g., electrolytic (green) hydrogen or hydrogen produced with carbon capture and storage (CCS). New chemical synthesis pathways based on captured carbon, so called carbon capture and utilization (CCU) is also highlighted, but the massive demand for renewable energy associated with this pathway is a significant barrier to its adoption in the near term. The report shows how efficiency improvements continues to be the main focus for reducing the climate impact of petrochemicals, but that this is a completely inadequate approach for achieving the emissions reductions necessary in the coming decades. Breakthrough technologies are unlikely to be deployed at a rate consistent with international climate targets, and there is a great risk in relying on the promises of technologies which are yet to be proven at scale. The large knowledge gaps that remain are key barriers for effective governance of the transition.
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| 3. |
- Guillaume, Joseph H. A., et al.
(författare)
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Giving Legs to Handprint Thinking : Foundations for Evaluating the Good We Do
- 2020
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Ingår i: Earth's Future. - 2328-4277. ; 8:6
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Tidskriftsartikel (refereegranskat)abstract
- In environmental management and sustainability there is an increasing interest in measurement and accounting of beneficial impact-as an incentive to action, as a communication tool, and to move toward a positive, constructive approach focused on opportunities rather than problems. One approach uses the metaphor of a handprint, complementing the notion of environmental footprints, which have been widely adopted for impact measurement and accounting. We analyze this idea by establishing core principles of handprint thinking: Handprint encourages actions with positive impacts and connects to analyses of footprint reductions but adds value to them and addresses the issue of what action should be taken. We also identify five key questions that need to be addressed and decisions that need to be made in performing a (potentially quantitative) handprint assessment, related to scoping of the improvement to be made, how it is achieved, and how credit is assigned, taking into account constraints on action. A case study of the potential water footprint reduction of an average Finn demonstrates how handprint thinking can be a natural extension of footprint reduction analyses. We find that there is a diversity of possible handprint assessments that have the potential to encourage doing good. Their common foundation is handprint thinking.
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| 4. |
- Konstantinou, Nikolaos, et al.
(författare)
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Revascularization of occluded renal artery stent grafts after complex endovascular aortic repair and its impact on renal function
- 2021
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Ingår i: Journal of Vascular Surgery. - : Elsevier. - 0741-5214 .- 1097-6809. ; 73:5, s. 1566-1572
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Acute occlusion of renal bridging stent grafts after fenestrated/branched endovascular aortic repair (F/B-EVAR) is an acknowledged complication with high morbidity that often results in chronic dialysis dependence. The feasibility and effect of timely or late (≥6 hours of ischemia) renal artery revascularization has not been adequately reported.METHODS: We performed a retrospective, multicenter study across 11 tertiary institutions of all consecutive patients who had undergone revascularization of renal artery stent graft occlusions after complex EVAR. The end points were technical success, association between ischemia time and renal function salvage, interventional complications, mortality, and mid-term outcomes.RESULTS: From 2009 to 2019, 38 patients with 46 target vessels (TVs; eight bilateral occlusions) were treated for renal artery occlusions after complex EVAR (mean age, 63.5 ± 10 years; 63.2% male). Six patients had a solitary kidney (15.8%). Of the 38 patients, 16 (42.1%) had undergone FEVAR and 22 (57.9%) had undergone BEVAR. The technical success rate was 95.7% (44 of 46 TVs). The recanalization technique used was sole aspiration thrombectomy in 5.3%, aspiration thrombectomy and stent graft relining in 52.6%, and sole stent graft relining in 36.8%. The median renal ischemia time was 27.5 hours (range, 4-720 hours; interquartile range, 4-36 hours). Most patients (94.4%) had been treated after ≥6 hours of renal ischemia time, and 55.6% had been treated after 24 hours. In 14 patients (36.8%), renal function had improved after intervention (mean glomerular filtration rate improvement, 14.2 ± 9 mL/min/1.73 m2). However, 24 patients (63.2%) showed no improvement. Improvement of renal function did not correlate with the length of renal ischemia time. Of the 14 patients with bilateral renal artery occlusion or a solitary kidney, 9 experienced partial recovery of renal function and no longer required hemodialysis. In-hospital mortality was 2.6%. The cause of renal stent graft occlusion could not be identified in 50% of the TVs (23 of 46). However, in 19 (41.3%), significant stenosis or a kink of the renal stent graft was found. The median follow-up was 11 months (interquartile range, 0-28 months). The estimated 1-year patient survival and patency rate of the renal stent grafts was 97.4% and 83.8%, respectively.CONCLUSIONS: Revascularization of occluded renal bridging stent grafts after F/B-EVAR is a safe and feasible technique and can lead to significant improvement of renal function, even after long ischemia times (>24 hours) of the renal parenchyma or bilateral occlusion, as long as residual perfusion of the renal parenchyma has been preserved. Also, the long-term patency rates justify aggressive management of renal artery occlusion after F/B-EVAR.
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| 5. |
- Northcott, Paul A, et al.
(författare)
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Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.
- 2014
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 511:7510, s. 428-428
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Tidskriftsartikel (refereegranskat)abstract
- Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to the developing child. Genomics has illuminated the extensive intertumoral heterogeneity of medulloblastoma, identifying four distinct molecular subgroups. Group 3 and group 4 subgroup medulloblastomas account for most paediatric cases; yet, oncogenic drivers for these subtypes remain largely unidentified. Here we describe a series of prevalent, highly disparate genomic structural variants, restricted to groups 3 and 4, resulting in specific and mutually exclusive activation of the growth factor independent 1 family proto-oncogenes, GFI1 and GFI1B. Somatic structural variants juxtapose GFI1 or GFI1B coding sequences proximal to active enhancer elements, including super-enhancers, instigating oncogenic activity. Our results, supported by evidence from mouse models, identify GFI1 and GFI1B as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene activation in a childhood cancer.
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| 6. |
- Schael, S, et al.
(författare)
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Precision electroweak measurements on the Z resonance
- 2006
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Ingår i: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
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Forskningsöversikt (refereegranskat)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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| 7. |
- Traeger, Ulrike, et al.
(författare)
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HTT-lowering reverses Huntington's disease immune dysfunction caused by NF kappa B pathway dysregulation
- 2014
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Ingår i: Brain. - : Oxford University Press (OUP). - 1460-2156 .- 0006-8950. ; 137, s. 819-833
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Tidskriftsartikel (refereegranskat)abstract
- Huntington's disease is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. The peripheral innate immune system contributes to Huntington's disease pathogenesis and has been targeted successfully to modulate disease progression, but mechanistic understanding relating this to mutant huntingtin expression in immune cells has been lacking. Here we demonstrate that human Huntington's disease myeloid cells produce excessive inflammatory cytokines as a result of the cell-intrinsic effects of mutant huntingtin expression. A direct effect of mutant huntingtin on the NF kappa B pathway, whereby it interacts with IKK gamma, leads to increased degradation of I kappa B and subsequent nuclear translocation of RelA. Transcriptional alterations in intracellular immune signalling pathways are also observed. Using a novel method of small interfering RNA delivery to lower huntingtin expression, we show reversal of disease-associated alterations in cellular function-the first time this has been demonstrated in primary human cells. Glucan-encapsulated small interfering RNA particles were used to lower huntingtin levels in human Huntington's disease monocytes/macrophages, resulting in a reversal of huntingtin-induced elevated cytokine production and transcriptional changes. These findings improve our understanding of the role of innate immunity in neurodegeneration, introduce glucan-encapsulated small interfering RNA particles as tool for studying cellular pathogenesis ex vivo in human cells and raise the prospect of immune cell-directed HTT-lowering as a therapeutic in Huntington's disease.
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| 8. |
- van Bragt, JJMH, et al.
(författare)
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Characteristics and treatment regimens across ERS SHARP severe asthma registries
- 2020
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Ingår i: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 55:1
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Tidskriftsartikel (refereegranskat)abstract
- Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals.This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases.Analysis of data from 3236 patients showed many differences in characteristics and lifestyle factors. Current smokers ranged from 0% (Poland and Sweden) to 9.5% (Belgium), mean body mass index ranged from 26.2 (Italy) to 30.6 kg·m−2 (the UK) and the largest difference in mean pre-bronchodilator forced expiratory volume in 1 s % predicted was 20.9% (the Netherlands versus Hungary). Before starting biologicals patients were treated differently between countries: mean inhaled corticosteroid dose ranged from 700 to 1335 µg·day−1 between those from Slovenia versus Poland when starting anti-interleukin (IL)-5 antibody and from 772 to 1344 µg·day−1 in those starting anti-IgE (Slovenia versus Spain). Maintenance oral corticosteroid use ranged from 21.0% (Belgium) to 63.0% (Sweden) and from 9.1% (Denmark) to 56.1% (the UK) in patients starting anti-IL-5 and anti-IgE, respectively.The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current European Respiratory Society/American Thoracic Society guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries.
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