| 1. |
- Jullesson, David, 1987, et al.
(författare)
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Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals
- 2015
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Ingår i: Biotechnology Advances. - : Elsevier BV. - 0734-9750. ; 33:7, s. 1395-1402
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Forskningsöversikt (refereegranskat)abstract
- Industrial bio-processes for fine chemical production are increasingly relying on cell factories developed through metabolic engineering and synthetic biology. The use of high throughput techniques and automation for the design of cell factories, and especially platform strains, has played an important role in the transition from laboratory research to industrial production. Model organisms such as Saccharomyces cerevisiae and Escherichia coli remain widely used host strains for industrial production due to their robust and desirable traits. This review describes some of the bio-based fine chemicals that have reached the market, key metabolic engineering tools that have allowed this to happen and some of the companies that are currently utilizing these technologies for developing industrial production processes.
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| 2. |
- Pfleger, B. F., et al.
(författare)
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Metabolic engineering strategies for microbial synthesis of oleochemicals
- 2015
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Ingår i: Metabolic Engineering. - : Elsevier BV. - 1096-7176 .- 1096-7184. ; 29, s. 1-11
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Microbial synthesis of oleochemicals has advanced significantly in the last decade. Microbes have been engineered to convert renewable substrates to a wide range of molecules that are ordinarily made from plant oils. This approach is attractive because it can reduce a motivation for converting tropical rainforest into farmland while simultaneously enabling access to molecules that are currently expensive to produce from oil crops. In the last decade, enzymes responsible for producing oleochemicals in nature have been identified, strategies to circumvent native regulation have been developed, and high yielding strains have been designed, built, and successfully demonstrated. This review will describe the metabolic pathways that lead to the diverse molecular features found in natural oleochemicals, highlight successful metabolic engineering strategies, and comment on areas where future work could further advance the field.
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