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1.	Madani, N, et al. (author) Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds 2016 In: Journal of virology. - 1098-5514. ; 90:10, s. 5031-5046 Journal article (peer-reviewed)
2.	Martinez-Murillo, P, et al. (author) Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach 2017 In: Immunity. - : Elsevier BV. - 1097-4180 .- 1074-7613. ; 46:5, s. 804- Journal article (peer-reviewed)
3.	Navis, M, et al. (author) HIV-1 receptor binding site-directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer immunization 2014 In: PLoS pathogens. - : Public Library of Science (PLoS). - 1553-7374. ; 10:8, s. e1004337- Journal article (peer-reviewed)
4.	Ols, S, et al. (author) Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses 2023 In: Immunity. - 1097-4180. ; 56:10, s. 2425-2441.e14 Journal article (peer-reviewed)
5.	Phad, GE, et al. (author) Diverse antibody genetic and recognition properties revealed following HIV-1 envelope glycoprotein immunization 2015 In: Journal of immunology (Baltimore, Md. : 1950). - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 194:12, s. 5903-5914 Journal article (peer-reviewed)abstract Isolation of mAbs elicited by vaccination provides opportunities to define the development of effective immunity. Ab responses elicited by current HIV-1 envelope glycoprotein (Env) immunogens display narrow neutralizing activity with limited capacity to block infection by tier 2 viruses. Intense work in the field suggests that improved Env immunogens are forthcoming, and it is therefore important to concurrently develop approaches to investigate the quality of vaccine-elicited responses at a higher level of resolution. In this study, we cloned a representative set of mAbs elicited by a model Env immunogen in rhesus macaques and comprehensively characterized their genetic and functional properties. The mAbs were genetically diverse, even within groups of Abs targeting the same subregion of Env, consistent with a highly polyclonal response. mAbs directed against two subdeterminants of Env, the CD4 binding site and V region 3, could in part account for the neutralizing activity observed in the plasma of the animal from which they were cloned, demonstrating the power of mAb isolation for a detailed understanding of the elicited response. Finally, through comparative analyses of mAb binding and neutralizing capacity of HIV-1 using matched Envs, we demonstrate complex relationships between epitope recognition and accessibility, highlighting the protective quaternary packing of the HIV-1 spike relative to vaccine-induced mAbs.
6.	Phad, GE, et al. (author) Genetic and Functional Characterization of Somatic Variants of Vaccine-Induced HIV-1 CD4bs-Directed Monoclonal Antibodies 2013 In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - 0889-2229. ; 29:11, s. A58-A58 Conference paper (other academic/artistic)

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Result 1-6 of 6

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Type of publication: journal article (5); conference paper (1)

Type of content: peer-reviewed (5); other academic/artistic (1)

Author/Editor: Hedestam, GBK (5); Corcoran, M. (2); Lore, K (2); Tran, K (2); O'Dell, S (2); Wyatt, RT (2); show more...; Bernat, NV (2); Sundling, C (2); Bale, S. (2); Guenaga, J (2); Li, Y. (1); Zhang, Z. (1); Kumar, A. (1); aut (1); Wyatt, R (1); Chen, M (1); Adori, M (1); Wilson, R (1); Dubrovskaya, V (1); Martinez-Murillo, P (1); Mascola, JR (1); Cagigi, A (1); Bradley, T (1); Lindgren, G (1); McKee, K (1); Lin, A (1); Feng, Y. (1); Sodroski, J (1); Perez, L (1); Thompson, EA (1); Li, YX (1); Pramanik, L (1); Ingale, J (1); Luo, K (1); Soldemo, M (1); Lenart, K (1); Hellgren, F (1); Kochmann, J. (1); Cerveira, RA (1); Santra, S. (1); Ols, S (1); Graham, BS (1); Moody, MA (1); Shapiro, L (1); Spangberg, M (1); Madani, N (1); Princiotto, AM (1); Easterhoff, D (1); Williams, WB (1); Liao, HX (1); show less...

University: Karolinska Institutet (6)

Language: English (6)

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