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- Campo, E, et al.
(författare)
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The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee
- 2022
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 140:11, s. 1229-1253
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Tidskriftsartikel (refereegranskat)abstract
- Since the publication of the Revised European-American Classification of Lymphoid Neoplasms in 1994, subsequent updates of the classification of lymphoid neoplasms have been generated through iterative international efforts to achieve broad consensus among hematopathologists, geneticists, molecular scientists, and clinicians. Significant progress has recently been made in the characterization of malignancies of the immune system, with many new insights provided by genomic studies. They have led to this proposal. We have followed the same process that was successfully used for the third and fourth editions of the World Health Organization Classification of Hematologic Neoplasms. The definition, recommended studies, and criteria for the diagnosis of many entities have been extensively refined. Some categories considered provisional have now been upgraded to definite entities. Terminology for some diseases has been revised to adapt nomenclature to the current knowledge of their biology, but these modifications have been restricted to well-justified situations. Major findings from recent genomic studies have impacted the conceptual framework and diagnostic criteria for many disease entities. These changes will have an impact on optimal clinical management. The conclusions of this work are summarized in this report as the proposed International Consensus Classification of mature lymphoid, histiocytic, and dendritic cell tumors.
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- De Simone, S., et al.
(författare)
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Gender and Entrepreneurship in Pandemic Time: What Demands and What Resources? An Exploratory Study
- 2021
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Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- Due to the coronavirus disease 2019 (COVID-19) epidemic, global economies have suffered an exogenous shock never seen before with a strong economic and psychosocial impact on organizations. Italy, in the context of the research, has been severely affected. The economic crisis has mainly affected women. In this scenario, entrepreneurial perceived success (objective and subjective) is influenced by increasingly burdensome job demands that entrepreneurs have to face up. Using the job demand-resources model, the study aims to broaden the knowledge of the determinants of entrepreneurial perceived success in the current emergency moment. In particular, as regards of the demands, alongside the specific entrepreneurial demands (time demands, uncertainty and risk, and responsibility), we also decided to include the negative interface family-work in both directions from-family-to-work (NEGWIF) and from-work-to-family (NEGFIW). Regarding the resources, we considered entrepreneurial self-efficacy (researching, planning, marshaling, implementing people, and implementing financial), proactive and elaborate social strategies (SS), and both directions of the positive interface: from-family-to-work (POSWIF) and from-work-to-family (POSFIW). All participants are women entrepreneurs (N = 137) who have completed a self-report questionnaire. We explored the associations between demands, resources, and the dimensions of success through hierarchical regressions. As for the demands, time demands, uncertainty and risk, NEGWIF, and NEGFIW negatively influenced the perceived entrepreneurial success. Regarding resources, planning, implementing financial, proactive and elaborate SS positively influenced the perceived entrepreneurial success.
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- De Simone, S., et al.
(författare)
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Mea Culpa! The Role of Guilt in the Work-Life Interface and Satisfaction of Women Entrepreneur
- 2022
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 19:17
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study is to analyze the role of mediator of Guilt (in both directions: Family Interference with Work (FIW) and Work Interference with Family (WIF)) in the relationship between Conflict, Job and Life Satisfaction, also investigating the role of Enrichment as moderator. Using PROCESS Macro, the hypothesized models are tested on a sample of 161 women entrepreneurs. Both the mediating role of guilt and the moderating role of enrichment were analyzed through models of mediation and moderate mediation. Results from the analysis support the hypothesized models. Guilt FIW and Guilt WIF mediate the relationship between work Conflict and Job satisfaction, as well the relationship between Conflict and Life satisfaction, and at the same time, Enrichment moderated the mediating processes by which the Conflict affects Job and Life satisfaction via Guilt FIW and Guilt WIF. This study is one of the few that takes into consideration both Conflict and Enrichment in a sample of women entrepreneurs and examines Guilt, which many times presents itself as an “invisible” factor in studies on the work–family interface. © 2022 by the authors.
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- Marafioti, Teresa, et al.
(författare)
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Novel markers of normal and neoplastic human plasmacytoid dendritic cells
- 2008
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 111:7, s. 3778-3792
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Forskningsöversikt (refereegranskat)abstract
- Plasmacytoid dendritic cells (pDCs) are involved in innate immunity (eg, by secreting interferons) and also give rise to CD4(+)CD56(+) hematodermic neoplasms. We report extensive characterization of human pDCs in routine tissue samples, documenting the expression of 19 immunohistologic markers, including signaling molecules (eg, BLNK), transcription factors (eg, ICSBP/IRF8 and PU.1), and Toll-like receptors (TLR7, TLR9). Many of these molecules are expressed in other cell types (principally B cells), but the adaptor protein CD2AP was essentially restricted to pDCs, and is therefore a novel immunohistologic marker for use in tissue biopsies. We found little evidence for activation-associated morphologic or phenotypic changes in conditions where pDCs are greatly increased (eg, Kikuchi disease). Most of the molecules were retained in the majority of pDC neoplasms, and 3 (BCL11A, CD2AP, and ICSBP/IRF8) were also commonly negative in leukemia cutis (acute myeloid leukemia in the skin), a tumor that may mimic pDC neoplasia. In summary, we have documented a range of molecules (notably those associated with B cells) expressed by pDCs in tissues and peripheral blood (where pDCs were detectable in cytospins at a frequency of < 1% of mononuclear cells) and also defined potential new markers (in particular CD2AP) for the diagnosis of pDC tumors.
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