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- Abbasi, A, et al.
(författare)
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Progress on Partial Discharge Detectionunder DC Voltage Stress
- 2019
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Detection and evaluation of partial discharges (PD) is important for quality assurance and diagnosis ofelectrical insulation systems. With increasing use of DC voltages in electrical transmission and distributionsystems, the field of PD under DC voltage stress needs to be further investigated.CIGRE Working Group D1.63 was approved for start in May 2015, where available knowledge and experiencein particular concerning the field distribution in insulation systems used in DC voltage systems, and thephysical processes of the PD phenomena under DC voltage stress should be reviewed. In order of guidingto meaningful procedures for DC PD measurements of HV equipment thorough understanding of i) thedifferences of PD behaviour between AC and DC with respect to the physical process and ii) influencingfactors of operating conditions (as e.g. polarization, temperature etc.) of different insulation systems underDC stress and respective effects on PD phenomena had to be examined.
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- Megyesfalvi, Zsolt, et al.
(författare)
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Clinical insights into small cell lung cancer : Tumor heterogeneity, diagnosis, therapy, and future directions
- 2023
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Ingår i: CA: a cancer journal for clinicians. - 0007-9235. ; 73:6, s. 620-652
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Forskningsöversikt (refereegranskat)abstract
- Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity. It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority of SCLCs exhibit neuroendocrine features, an important subset of tumors lacks these properties. Genomic profiling of SCLC reveals genetic instability, almost universal inactivation of the tumor suppressor genes TP53 and RB1, and a high mutation burden. Because of early metastasis, only a small fraction of patients are amenable to curative-intent lung resection, and these individuals require adjuvant platinum-etoposide chemotherapy. Therefore, the vast majority of patients are currently being treated with chemoradiation with or without immunotherapy. In patients with disease confined to the chest, standard therapy includes thoracic radiotherapy and concurrent platinum-etoposide chemotherapy. Patients with metastatic (extensive-stage) disease are treated with a combination of platinum-etoposide chemotherapy plus immunotherapy with an anti-programmed death-ligand 1 monoclonal antibody. Although SCLC is initially very responsive to platinum-based chemotherapy, these responses are transient because of the development of drug resistance. In recent years, the authors have witnessed an accelerating pace of biologic insights into the disease, leading to the redefinition of the SCLC classification scheme. This emerging knowledge of SCLC molecular subtypes has the potential to define unique therapeutic vulnerabilities. Synthesizing these new discoveries with the current knowledge of SCLC biology and clinical management may lead to unprecedented advances in SCLC patient care. Here, the authors present an overview of multimodal clinical approaches in SCLC, with a special focus on illuminating how recent advancements in SCLC research could accelerate clinical development.
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