| 1. |
- Kruijff-Korbayová, I, et al.
(författare)
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TRADR Project : Long-Term Human-Robot Teaming for Robot Assisted Disaster Response
- 2015
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Ingår i: Künstliche Intelligenz. - : Springer. - 0933-1875 .- 1610-1987. ; 29:2, s. 193-201
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes the project TRADR: Long-Term Human-Robot Teaming for Robot Assisted Disaster Response. Experience shows that any incident serious enough to require robot involvement will most likely involve a sequence of sorties over several hours, days and even months. TRADR focuses on the challenges that thus arise for the persistence of environment models, multi-robot action models, and human-robot teaming, in order to allow incremental capability improvement over the duration of a mission. TRADR applies a user centric design approach to disaster response robotics, with use cases involving the response to a medium to large scale industrial accident by teams consisting of human rescuers and several robots (both ground and airborne). This paper describes the fundamentals of the project: the motivation, objectives and approach in contrast to related work.
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| 2. |
- Zanon, M., et al.
(författare)
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Microwave-assisted methacrylation of chitosan for 3D printable hydrogels in tissue engineering
- 2022
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Ingår i: Materials Advances. - : Royal Society of Chemistry (RSC). - 2633-5409. ; 3:1, s. 514-525
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Tidskriftsartikel (refereegranskat)abstract
- Light processable natural polymers are highly attractive for 3D printing of biomedical hydrogels with defined geometries and sizes. However, functionalization with photo-curable groups, such as methacrylate or acrylate groups, is required. Here, we investigated a microwave-assisted process for methacrylation of chitosan to replace conventional methacrylation processes that can be time consuming and tedious. The microwave-assisted methacrylation reaction was optimized by varying the synthesis parameters such as the molar ratio of chitosan to the methacrylic agent, the launch and reaction times and process temperature. The optimized process was fast and efficient and allowed tuning of the degree of substitution and thereby the final hydrogel properties. The successful methacrylation and degree of substitution were verified by 1H NMR and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). The influence of the degree of methacrylation on photo-rheology, mechanical stiffness, swelling degree and gel content was evaluated. Furthermore, favourable 3D printability, enzymatic degradability, biocompatibility, cell migration and proliferation were demonstrated giving promise for further applications in tissue engineering.
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| 3. |
- Berto, Marcello, et al.
(författare)
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Biorecognition in Organic Field Effect Transistors Biosensors: The Role of the Density of States of the Organic Semiconductor
- 2016
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Ingår i: ANALYTICAL CHEMISTRY. - : AMER CHEMICAL SOC. - 0003-2700 .- 1520-6882. ; 88:24, s. 12330-12338
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Tidskriftsartikel (refereegranskat)abstract
- Biorecognition is a central event in biological processes in the living systems that is also widely exploited in technological and health applications. We demonstrate that the Electrolyte Gated Organic Field Effect Transistor (EGOFET) is an ultrasensitive and specific device that allows us to quantitatively assess the thermodynamics of biomolecular recognition between a human antibody and its antigen, namely, the inflammatory cytokine TNF alpha at the solid/liquid interface. The EGOFET biosensor exhibits a superexponential response at TNF alpha concentration below 1 nM with a minimum detection level of 100 pM. The sensitivity of the device depends on the analyte concentration, reaching a maximum in the range of clinically relevant TNF alpha concentrations when the EGOFET is operated in the subthreshold regime. At concentrations greater than 1 nM the response scales linearly with the concentration. The sensitivity and the dynamic range are both modulated by the gate voltage. These results are explained by establishing the correlation between the sensitivity and the density of states (DOS) of the organic semiconductor. Then, the superexponential response arises from the energy-dependence of the tail of the DOS of the HOMO level. From the gate voltage-dependent response, we extract the binding constant, as well as the changes of the surface charge and the effective capacitance accompanying biorecognition at the electrode surface. Finally, we demonstrate the detection of TNF alpha in human-plasma derived samples as an example for point-of-care application.
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