| 1. |
- Dubol, Manon, et al.
(författare)
-
Neuroimaging the menstrual cycle : A multimodal systematic review
- 2021
-
Ingår i: Frontiers in neuroendocrinology (Print). - : Frontiers Media S.A.. - 0091-3022 .- 1095-6808. ; 60
-
Tidskriftsartikel (refereegranskat)abstract
- Increasing evidence indicates that ovarian hormones affect brain structure, chemistry and function of women in their reproductive age, potentially shaping their behavior and mental health. Throughout the reproductive years, estrogens and progesterone levels fluctuate across the menstrual cycle and can modulate neural circuits involved in affective and cognitive processes. Here, we review seventy-seven neuroimaging studies and provide a comprehensive and data-driven evaluation of the accumulating evidence on brain plasticity associated with endogenous ovarian hormone fluctuations in naturally cycling women (n = 1304). The results particularly suggest modulatory effects of ovarian hormones fluctuations on the reactivity and structure of cortico-limbic brain regions. These findings highlight the importance of performing multimodal neuroimaging studies on neural correlates of systematic ovarian hormone fluctuations in naturally cycling women based on careful menstrual cycle staging.
|
|
| 2. |
|
|
| 3. |
- Hidalgo-Lopez, Esmeralda, et al.
(författare)
-
Triple network model of brain connectivity changes related to adverse mood effects in an oral contraceptive placebo-controlled trial
- 2023
-
Ingår i: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 13:1
-
Tidskriftsartikel (refereegranskat)abstract
- Combined oral contraceptives (COC) are among the most commonly used contraceptive methods worldwide, and mood side effects are the major reason for discontinuation of treatment. We here investigate the directed connectivity patterns associated with the mood side effects of an androgenic COC in a double-blind randomized, placebo-controlled trial in women with a history of affective COC side effects (n = 34). We used spectral dynamic causal modeling on a triple network model consisting of the default mode network (DMN), salience network (SN) and executive control network (ECN). Within this framework, we assessed the treatment-related changes in directed connectivity associated with adverse mood side effects. Overall, during COC use, we found a pattern of enhanced connectivity within the DMN and decreased connectivity within the ECN. The dorsal anterior cingulate cortex (SN) mediates an increased recruitment of the DMN by the ECN during treatment. Mood lability was the most prominent COC-induced symptom and also arose as the side effect most consistently related to connectivity changes. Connections that were related to increased mood lability showed increased connectivity during COC treatment, while connections that were related to decreased mood lability showed decreased connectivity during COC treatment. Among these, the connections with the highest effect size could also predict the participants' treatment group above chance.
|
|
| 4. |
- Petersen, Nicole, et al.
(författare)
-
Towards a more comprehensive neuroscience of hormonal contraceptives
- 2023
-
Ingår i: Nature Neuroscience. - : Springer Nature. - 1097-6256 .- 1546-1726. ; 26:4, s. 529-531
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The neuroscience of hormonal contraceptives is a vital but relatively new field. Existing studies are limited in size and scope, but they nonetheless highlight that the effects of hormonal contraceptives on the nervous system are complex and can vary because of individual differences, contraceptive type and formulation, and timing of use, among other factors. Neuroscientists can empower individuals with information about the biopsychological effects of hormonal contraceptives by delving more deeply into these effects in rigorous randomized controlled trials, large-scale studies that examine population-level trends, and dense imaging or intensive longitudinal studies that examine individual-level effects.
|
|
| 5. |
|
|
| 6. |
- Scheuringer, Andrea, et al.
(författare)
-
Use of an estradiol-based combined oral contraceptives has no influence on attentional bias or depressive symptoms in healthy women
- 2020
-
Ingår i: Psychoneuroendocrinology. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0306-4530 .- 1873-3360. ; 113
-
Tidskriftsartikel (refereegranskat)abstract
- Combined oral contraceptive (COC) use is associated with small, albeit significant, increases in mental symptom scores, predominantly irritability, depressed mood, and anxiety. Yet, randomized prospective trials are needed to better characterize the women at risk for COC-induced negative mood change. Thus, the primary aim of this sub-study to a placebo-controlled randomized trial was to determine wheher COC use influences emotional interference by negative and positive stimuli. Secondly, we wanted to evaluate what factors would predict depressive symptoms at the end of the trial, taking personality factors, history of mental disorders and other demographic factors into account. Sixty-nine women were included, randomized to three cycles of treatment with a COC (1.5 mg estradiol and 2.5 mg nomegestrolacetate) or placebo. An emotional verbal Stroop task was used to measure interference of emotional stimuli, in which participants were asked to only name the color of a presented word, while ignoring the meaning of the word. Four different word categories were used; neutral, positive, depression, and anxiety. For the second aim of the study, rating on the Montgomery-Asberg Depression Rating Scale during the final days of the trial was used as outcome. We found no interaction between emotional verbal Stroop word category and treatment, indicating that COC treatment did not evoke any differences in emotional interference to the three word categories. Significant predictors for depressive symptoms at the end of the trial were trait anxiety at baseline and prior adverse mood effects by hormonal contraceptive use. Treatment (i.e. whether women had been treated with the COC or placebo) did not play a role in predicting depression scores at the end of the trial. In conclusion, we found no evidence that combined oral contraceptive use is associated with impaired cognitive-emotional processing. Instead, the main predictors of self-rated depression at the end of the trial were baseline trait anxiety and previous mental symptoms during hormonal contraceptive use.
|
|
