| 1. |
- Eichhorst, B., et al.
(författare)
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First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia.
- 2023
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Ingår i: New England Journal of Medicine. - : MASSACHUSETTS MEDICAL SOC. - 0028-4793 .- 1533-4406. ; 388:19, s. 1739-1754
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Tidskriftsartikel (refereegranskat)abstract
- Background Randomized trials of venetoclax plus anti-CD20 antibodies as first-line treatment in fit patients (i.e., those with a low burden of coexisting conditions) with advanced chronic lymphocytic leukemia (CLL) have been lacking. Methods In a phase 3, open-label trial, we randomly assigned, in a 1:1:1:1 ratio, fit patients with CLL who did not have TP53 aberrations to receive six cycles of chemoimmunotherapy (fludarabine-cyclophosphamide-rituximab or bendamustine-rituximab) or 12 cycles of venetoclax-rituximab, venetoclax-obinutuzumab, or venetoclax-obinutuzumab-ibrutinib. Ibrutinib was discontinued after two consecutive measurements of undetectable minimal residual disease or could be extended. The primary end points were undetectable minimal residual disease (sensitivity,
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| 2. |
- Hansen, Lea B.S., et al.
(författare)
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A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
- 2018
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- © 2018, The Author(s). Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.
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| 3. |
- Abulaiti, Yiming, et al.
(författare)
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A search for pair-produced resonances in four-jet final states at root s=13 TeV with the ATLAS detector
- 2018
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 78:3
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Tidskriftsartikel (refereegranskat)abstract
- A search for massive coloured resonances which are pair-produced and decay into two jets is presented. The analysis uses 36.7 fb(-1) of root s = 13 TeV pp collision data recorded by the ATLAS experiment at the LHC in 2015 and 2016. No significant deviation from the background prediction is observed. Results are interpreted in a SUSY simplified model where the lightest supersymmetric particle is the top squark, (t) over tilde, which decays promptly into two quarks through R-parity-violating couplings. Top squarks with masses in the range 100 GeV < m((T) over tilde) < 410 GeV are excluded at 95% confidence level. If the decay is into a b-quark and a light quark, a dedicated selection requiring two b-tags is used to exclude masses in the ranges 100 GeV < m((t) over tilde) < 470 GeV and 480 GeV < m(<(t)over tilde>) < 610 GeV. Additional limits are set on the pair-production of massive colour-octet resonances.
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| 4. |
- Abulaiti, Yiming, et al.
(författare)
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Analysis of the Wtb vertex from the measurement of triple-differential angular decay rates of single top quarks produced in the t-channel at root s=8 TeV with the ATLAS detector
- 2017
-
Ingår i: Journal of High Energy Physics (JHEP). - : Springer Berlin/Heidelberg. - 1126-6708 .- 1029-8479. ; :12
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Tidskriftsartikel (refereegranskat)abstract
- The electroweak production and subsequent decay of single top quarks in the t-channel is determined by the properties of the Wtb vertex, which can be described by the complex parameters of an effective Lagrangian. An analysis of a triple-differential decay rate in t-channel production is used to simultaneously determine five generalised helicity fractions and phases, as well as the polarisation of the produced top quark. The complex parameters are then constrained. This analysis is based on 20.2 fb(-1) of proton-proton collision data at a centre-of-mass energy of 8 TeV collected with the ATLAS detector at the LHC. The fraction of decays containing transversely polarised W bosons is measured to be f(1) = 0.30 +/- 0.05. The phase between amplitudes for transversely and longitudinally polarised W bosons recoiling against left-handed b-quarks is measured to be delta = 0.002 pi(+0.016 pi)(+0.017 pi), giving no indication of CP violation. The fractions of longitudinal or transverse W bosons accompanied by right-handed b-quarks are also constrained. Based on these measurements, limits are placed at 95% CL on the ratio of the complex coupling parameters Re [g(R)/V-L is an element of [-0.12, 0.17] and Im [g(R)/V-L is an element of [-0.07, 0.06]. Constraints are also placed on the ratios vertical bar V-R/V-L vertical bar and vertical bar g(L)/V-L vertical bar. In addition, the polarisation of single top quarks in the t-channel is constrained to be P > 0.72 (95% CL). None of the above measurements make assumptions about the value of any of the other parameters or couplings and all of them are in agreement with the Standard Model.
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| 5. |
- Abulaiti, Yiming, et al.
(författare)
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Identification and rejection of pile-up jets at high pseudorapidity with the ATLAS detector
- 2017
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:9
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Tidskriftsartikel (refereegranskat)abstract
- The rejection of forward jets originating from additional proton-proton interactions (pile-up) is crucial for a variety of physics analyses at the LHC, including Standard Model measurements and searches for physics beyond the Standard Model. The identification of such jets is challenging due to the lack of track and vertex information in the pseudorapidity range vertical bar eta vertical bar > 2.5. This paper presents a novel strategy for forward pile-up jet tagging that exploits jet shapes and topological jet correlations in pile-up interactions. Measurements of the per-jet tagging efficiency are presented using a data set of 3.2 fb(-1) of proton-proton collisions at a centre-of-mass energy of 13 TeV collected with the ATLAS detector. The fraction of pile-up jets rejected in the range 2.5 < vertical bar eta vertical bar < 4.5 is estimated in simulated events with an average of 22 interactions per bunch-crossing. It increases with jet transverse momentum and, for jets with transverse momentum between 20 and 50 GeV, it ranges between 49% and 67% with an efficiency of 85% for selecting hard-scatter jets. A case study is performed in Higgs boson production via the vector-boson fusion process, showing that these techniques mitigate the background growth due to additional proton-proton interactions, thus enhancing the reach for such signatures.
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| 6. |
- Abulaiti, Yiming, et al.
(författare)
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Jet energy scale measurements and their systematic uncertainties in proton-proton collisions at root s=13 TeV with the ATLAS detector
- 2017
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Ingår i: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 96:7
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Tidskriftsartikel (refereegranskat)abstract
- Jet energy scale measurements and their systematic uncertainties are reported for jets measured with the ATLAS detector using proton-proton collision data with a center-of-mass energy of root s = 13 TeV, corresponding to an integrated luminosity of 3.2 fb(-1) collected during 2015 at the LHC. Jets are reconstructed from energy deposits forming topological clusters of calorimeter cells, using the anti-k(t) algorithm with radius parameter R = 0.4. Jets are calibrated with a series of simulation-based corrections and in situ techniques. In situ techniques exploit the transverse momentum balance between a jet and a reference object such as a photon, Z boson, or multijet system for jets with 20 < p(T) < 2000 GeV and pseudorapidities of vertical bar eta vertical bar < 4.5, using both data and simulation. An uncertainty in the jet energy scale of less than 1% is found in the central calorimeter region (vertical bar eta vertical bar < 1.2) for jets with 100 < p(T) < 500 GeV. An uncertainty of about 4.5% is found for low-p(T) jets with p(T) = 20 GeV in the central region, dominated by uncertainties in the corrections for multiple proton-proton interactions. The calibration of forward jets (vertical bar eta vertical bar > 0.8) is derived from dijet p(T) balance measurements. For jets of p(T) = 80 GeV, the additional uncertainty for the forward jet calibration reaches its largest value of about 2% in the range vertical bar eta vertical bar > 3.5 and in a narrow slice of 2.2 < vertical bar eta vertical bar < 2.4.
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| 7. |
- Abulaiti, Yiming, et al.
(författare)
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Measurement of b-hadron pair production with the ATLAS detector in proton-proton collisions at root s=8 TeV
- 2017
-
Ingår i: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; :11
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Tidskriftsartikel (refereegranskat)abstract
- A measurement of b-hadron pair production is presented, based on a data set corresponding to an integrated luminosity of 11.4 fb(-1) of proton-proton collisions recorded at root s = 8TeV with the ATLAS detector at the LHC. Events are selected in which a b-hadron is reconstructed in a decay channel containing J = psi -> mu mu, and a second b-hadron is reconstructed in a decay channel containing a muon. Results are presented in a fiducial volume de fined by kinematic requirements on three muons based on those used in the analysis. The fiducial cross section is measured to be 17.7 +/- 0.1(stat.) +/- 2.0(syst.) nb. A number of normalised differential cross sections are also measured, and compared to predictions from the PYTHIA8, HERWIG++, MADGRAPH5_AMC@NLO+PYTHIA8 and SHERPA event generators, providing new constraints on heavy flavour production.
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| 8. |
- Abulaiti, Yiming, et al.
(författare)
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Measurement of detector-corrected observables sensitive to the anomalous production of events with jets and large missing transverse momentum in pp collisions at root s=13 TeV using the ATLAS detector
- 2017
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:11
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Tidskriftsartikel (refereegranskat)abstract
- Observables sensitive to the anomalous production of events containing hadronic jets and missing momentum in the plane transverse to the proton beams at the Large Hadron Collider are presented. The observables are defined as a ratio of cross sections, for events containing jets and large missing transverse momentum to events containing jets and a pair of charged leptons from the decay of a Z/gamma* boson. This definition minimises experimental and theoretical systematic uncertainties in the measurements. This ratio is measured differentially with respect to a number of kinematic properties of the hadronic system in two phase-space regions; one inclusive single-jet region and one region sensitive to vector-boson-fusion topologies. The data are found to be in agreement with the Standard Model predictions and used to constrain a variety of theoretical models for dark-matter production, including simplified models, effective field theory models, and invisible decays of the Higgs boson. The measurements use 3.2 fb(-1) of proton-proton collision data recorded by the ATLAS experiment at a centre-of-mass energy of 13TeV and are fully corrected for detector effects, meaning that the data can be used to constrain new-physics models beyond those shown in this paper.
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| 9. |
- Abulaiti, Yiming, et al.
(författare)
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Measurement of differential cross sections and W+/W- cross-section ratios for W boson production in association with jets at root s=8 TeV with the ATLAS detector
- 2018
-
Ingår i: Journal of High Energy Physics (JHEP). - : Springer-Verlag New York. - 1126-6708 .- 1029-8479. ; :5
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a measurement of the W boson production cross section and the W+/W- cross-section ratio, both in association with jets, in proton-proton collisions at root s = 8 TeV with the ATLAS experiment at the Large Hadron Collider. The measurement is performed in final states containing one electron and missing transverse momentum using data corresponding to an integrated luminosity of 20.2 fb(-1). Differential cross sections for events with at least one or two jets are presented for a range of observables, including jet transverse momenta and rapidities, the scalar sum of transverse momenta of the visible particles and the missing transverse momentum in the event, and the transverse momentum of the W boson. For a subset of the observables, the differential cross sections of positively and negatively charged W bosons are measured separately. In the cross-section ratio of W+/W- the dominant systematic uncertainties cancel out, improving the measurement precision by up to a factor of nine. The observables and ratios selected for this paper provide valuable input for the up quark, down quark, and gluon parton distribution functions of the proton.
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| 10. |
- Abulaiti, Yiming, et al.
(författare)
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Measurement of inclusive and differential cross sections in the H -> ZZ* -> 4l decay channel in pp collisions at root s=13 TeV with the ATLAS detector
- 2017
-
Ingår i: Journal of High Energy Physics (JHEP). - : SPRINGER. - 1126-6708 .- 1029-8479. ; :10
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Tidskriftsartikel (refereegranskat)abstract
- Inclusive and differential fiducial cross sections of Higgs boson production in proton-proton collisions are measured in the H -> Z Z* -> 4l decay channel. The proton-proton collision data were produced at the Large Hadron Collider at a centre-of-mass energy of 13 TeV and recorded by the ATLAS detector in 2015 and 2016, corresponding to an integrated luminosity of 36.1 fb(-1). The inclusive fiducial cross section in the H -> Z Z* -> 4l decay channel is measured to be 3.62 +/- 0.50 (stat) (+0.25)(-0.20) (sys) fb, in agreement with the Standard Model prediction of 2.91 +/- 0.13 fb. The cross section is also extrapolated to the total phase space including all Standard Model Higgs boson decays. Several differential fiducial cross sections are measured for observables sensitive to the Higgs boson production and decay, including kinematic distributions of jets produced in association with the Higgs boson. Good agreement is found between data and Standard Model predictions. The results are used to put constraints on anomalous Higgs boson interactions with Standard Model particles, using the pseudo-observable extension to the kappa-framework.
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