| 1. |
- Hansen, Lea B.S., et al.
(författare)
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A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
- 2018
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- © 2018, The Author(s). Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.
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| 2. |
- Abulaiti, Yiming, et al.
(författare)
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Measurement of quarkonium production in proton-lead and proton-proton collisions at 5.02 TeV with the ATLAS detector
- 2018
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 78:3
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Tidskriftsartikel (refereegranskat)abstract
- The modification of the production of J/psi, psi(2S), and gamma (nS) (n = 1, 2, 3) in p+Pb collisions with respect to their production in pp collisions has been studied. The p+Pb and pp datasets used in this paper correspond to integrated luminosities of 28 nb(-1) and 25 pb(-1) respectively, collected in 2013 and 2015 by the ATLAS detector at the LHC, both at a centre-of-mass energy per nucleon pair of 5.02 TeV. The quarkonium states are reconstructed in the dimuon decay channel. The yields of J/psi and psi(2S) are separated into prompt and non-prompt sources. The measured quarkonium differential cross sections are presented as a function of rapidity and transverse momentum, as is the nuclear modification factor, R-pPb for J/psi and psi (nS). No significant modification of the J/psi production is observed while gamma (nS) production is found to be suppressed at low transverse momentum in p+Pb collisions relative to pp collisions. The production of excited charmonium and bottomonium states is found to be suppressed relative to that of the ground states in central p+Pb collisions.
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| 3. |
- Perner, Anders, et al.
(författare)
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Hydroxyethyl Starch 130/0.4 versus Ringer's Acetate in Severe Sepsis
- 2012
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 367:2, s. 124-134
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Hydroxyethyl starch (HES) 130/0.4 is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established in patients with severe sepsis. METHODS In this multicenter, parallel-group, blinded trial, we randomly assigned patients with severe sepsis to fluid resuscitation in the ICU with either 6% HES 130/0.4 or Ringer's acetate at a dose of up to 33 ml per kilogram of ideal body weight per day. The primary outcome measure was either death or end-stage kidney failure (dependence on dialysis) at 90 days after randomization. RESULTS Of the 804 patients who underwent randomization, 798 were included in the modified intention-to-treat population. The two intervention groups had similar baseline characteristics. At 90 days after randomization, 201 of 398 patients (51%) assigned to HES 130/0.4 had died, as compared with 172 of 400 patients (43%) assigned to Ringer's acetate (relative risk, 1.17; 95% confidence interval [CI], 1.01 to 1.36; P=0.03); 1 patient in each group had end-stage kidney failure. In the 90-day period, 87 patients (22%) assigned to HES 130/0.4 were treated with renal-replacement therapy versus 65 patients (16%) assigned to Ringer's acetate (relative risk, 1.35; 95% CI, 1.01 to 1.80; P=0.04), and 38 patients (10%) and 25 patients (6%), respectively, had severe bleeding (relative risk, 1.52; 95% CI, 0.94 to 2.48; P=0.09). The results were supported by multivariate analyses, with adjustment for known risk factors for death or acute kidney injury at baseline. CONCLUSIONS Patients with severe sepsis assigned to fluid resuscitation with HES 130/0.4 had an increased risk of death at day 90 and were more likely to require renal-replacement therapy, as compared with those receiving Ringer's acetate.
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| 4. |
- Roswall, Nina, et al.
(författare)
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Long-term exposure to traffic noise and risk of incident colon cancer : A pooled study of eleven Nordic cohorts
- 2023
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Ingår i: Environmental Research. - : Elsevier BV. - 0013-9351 .- 1096-0953. ; 224
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundColon cancer incidence is rising globally, and factors pertaining to urbanization have been proposed involved in this development. Traffic noise may increase colon cancer risk by causing sleep disturbance and stress, thereby inducing known colon cancer risk-factors, e.g. obesity, diabetes, physical inactivity, and alcohol consumption, but few studies have examined this.ObjectivesThe objective of this study was to investigate the association between traffic noise and colon cancer (all, proximal, distal) in a pooled population of 11 Nordic cohorts, totaling 155,203 persons.MethodsWe identified residential address history and estimated road, railway, and aircraft noise, as well as air pollution, for all addresses, using similar exposure models across cohorts. Colon cancer cases were identified through national registries. We analyzed data using Cox Proportional Hazards Models, adjusting main models for harmonized sociodemographic and lifestyle data.ResultsDuring follow-up (median 18.8 years), 2757 colon cancer cases developed. We found a hazard ratio (HR) of 1.05 (95% confidence interval (CI): 0.99–1.10) per 10-dB higher 5-year mean time-weighted road traffic noise. In sub-type analyses, the association seemed confined to distal colon cancer: HR 1.06 (95% CI: 0.98–1.14). Railway and aircraft noise was not associated with colon cancer, albeit there was some indication in sub-type analyses that railway noise may also be associated with distal colon cancer. In interaction-analyses, the association between road traffic noise and colon cancer was strongest among obese persons and those with high NO2-exposure.DiscussionA prominent study strength is the large population with harmonized data across eleven cohorts, and the complete address-history during follow-up. However, each cohort estimated noise independently, and only at the most exposed façade, which may introduce exposure misclassification. Despite this, the results of this pooled study suggest that traffic noise may be a risk factor for colon cancer, especially of distal origin.
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| 5. |
- Aad, G, et al.
(författare)
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Identification of boosted Higgs bosons decaying into b-quark pairs with the ATLAS detector at 13 TeV
- 2019
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:10
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes a study of techniques for identifying Higgs bosons at high transverse momenta decaying into bottom-quark pairs, H→ bb¯ , for proton–proton collision data collected by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy s=13 TeV. These decays are reconstructed from calorimeter jets found with the anti-ktR= 1.0 jet algorithm. To tag Higgs bosons, a combination of requirements is used: b-tagging of R= 0.2 track-jets matched to the large-R calorimeter jet, and requirements on the jet mass and other jet substructure variables. The Higgs boson tagging efficiency and corresponding multijet and hadronic top-quark background rejections are evaluated using Monte Carlo simulation. Several benchmark tagging selections are defined for different signal efficiency targets. The modelling of the relevant input distributions used to tag Higgs bosons is studied in 36 fb- 1 of data collected in 2015 and 2016 using g→ bb¯ and Z(→ bb¯) γ event selections in data. Both processes are found to be well modelled within the statistical and systematic uncertainties. © 2019, CERN for the benefit of the ATLAS collaboration.
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| 6. |
- Aad, G, et al.
(författare)
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Measurement of the Z(→ ℓ + ℓ −)γ production cross-section in pp collisions at √s = 13 TeV with the ATLAS detector
- 2020
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Ingår i: Journal of High Energy Physics. - : SPRINGER. - 1029-8479 .- 1126-6708. ; 2020:3
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Tidskriftsartikel (refereegranskat)abstract
- The production of a prompt photon in association with a Z boson is studied in proton-proton collisions at a centre-of-mass energy s = 13 TeV. The analysis uses a data sample with an integrated luminosity of 139 fb−1 collected by the ATLAS detector at the LHC from 2015 to 2018. The production cross-section for the process pp → ℓ+ℓ−γ + X (ℓ = e, μ) is measured within a fiducial phase-space region defined by kinematic requirements on the photon and the leptons, and by isolation requirements on the photon. An experimental precision of 2.9% is achieved for the fiducial cross-section. Differential cross-sections are measured as a function of each of six kinematic variables characterising the ℓ+ℓ−γ system. The data are compared with theoretical predictions based on next-to-leading-order and next-to-next-to-leading-order perturbative QCD calculations. The impact of next-to-leading-order electroweak corrections is also considered.
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| 7. |
- Aad, G, et al.
(författare)
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Measurements of the Higgs boson inclusive and differential fiducial cross sections in the 4 ℓ decay channel at √s = 13 TeV
- 2020
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 80:10
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Tidskriftsartikel (refereegranskat)abstract
- Inclusive and differential fiducial cross sections of the Higgs boson are measured in the H→ ZZ∗→ 4 ℓ (ℓ= e, μ) decay channel. The results are based on proton−proton collision data produced at the Large Hadron Collider at a centre-of-mass energy of 13 TeV and recorded by the ATLAS detector from 2015 to 2018, equivalent to an integrated luminosity of 139 fb - 1. The inclusive fiducial cross section for the H→ ZZ∗→ 4 ℓ process is measured to be σfid= 3.28 ± 0.32 fb, in agreement with the Standard Model prediction of σfid , SM= 3.41 ± 0.18 fb. Differential fiducial cross sections are measured for a variety of observables which are sensitive to the production and decay of the Higgs boson. All measurements are in agreement with the Standard Model predictions. The results are used to constrain anomalous Higgs boson interactions with Standard Model particles. © 2020, The Author(s).
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| 8. |
- Aad, G, et al.
(författare)
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Performance of electron and photon triggers in ATLAS during LHC Run 2
- 2020
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 80:1
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Tidskriftsartikel (refereegranskat)abstract
- Results are presented from the measurement by ATLAS of long-range (| Δ η| > 2) dihadron angular correlations in s=8 and 13 TeV pp collisions containing a Z boson. The analysis is performed using 19.4 fb - 1 of s=8 TeV data recorded during Run 1 of the LHC and 36.1 fb - 1 of s=13 TeV data recorded during Run 2. Two-particle correlation functions are measured as a function of relative azimuthal angle over the relative pseudorapidity range 2 < | Δ η| < 5 for different intervals of charged-particle multiplicity and transverse momentum. The measurements are corrected for the presence of background charged particles generated by collisions that occur during one passage of two colliding proton bunches in the LHC. Contributions to the two-particle correlation functions from hard processes are removed using a template-fitting procedure. Sinusoidal modulation in the correlation functions is observed and quantified by the second Fourier coefficient of the correlation function, v2 , 2, which in turn is used to obtain the single-particle anisotropy coefficient v2. The v2 values in the Z-tagged events, integrated over 0.5 < pT< 5 GeV, are found to be independent of multiplicity and s, and consistent within uncertainties with previous measurements in inclusive pp collisions. As a function of charged-particle pT, the Z-tagged and inclusive v2 values are consistent within uncertainties for pT< 3 GeV. © 2020, CERN for the benefit of the ATLAS collaboration.
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| 9. |
- Aad, G, et al.
(författare)
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Search for diboson resonances in hadronic final states in 139 fb−1 of pp collisions at √s = 13 TeV with the ATLAS detector
- 2019
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Ingår i: Journal of High Energy Physics. - : SPRINGER. - 1029-8479 .- 1126-6708. ; 2019:9
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Tidskriftsartikel (refereegranskat)abstract
- Narrow resonances decaying into W W, W Z or ZZ boson pairs are searched for in 139 fb−1 of proton-proton collision data at a centre-of-mass energy of s = 13 TeV recorded with the ATLAS detector at the Large Hadron Collider from 2015 to 2018. The diboson system is reconstructed using pairs of high transverse momentum, large-radius jets. These jets are built from a combination of calorimeter- and tracker-inputs compatible with the hadronic decay of a boosted W or Z boson, using jet mass and substructure properties. The search is performed for diboson resonances with masses greater than 1.3 TeV. No significant deviations from the background expectations are observed. Exclusion limits at the 95% confidence level are set on the production cross-section times branching ratio into dibosons for resonances in a range of theories beyond the Standard Model, with the highest excluded mass of a new gauge boson at 3.8 TeV in the context of mass-degenerate resonances that couple predominantly to gauge bosons.[Figure not available: see fulltext.]. © 2019, The Author(s).
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| 10. |
- Aad, G, et al.
(författare)
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Search for direct production of electroweakinos in final states with missing transverse momentum and a Higgs boson decaying into photons in pp collisions at √s = 13 TeV with the ATLAS detector
- 2020
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Ingår i: Journal of High Energy Physics. - : Springer Nature. - 1029-8479 .- 1126-6708. ; 2020:10
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Tidskriftsartikel (refereegranskat)abstract
- A search for a chargino-neutralino pair decaying via the 125 GeV Higgs boson into photons is presented. The study is based on the data collected between 2015 and 2018 with the ATLAS detector at the LHC, corresponding to an integrated luminosity of 139 fb−1 of pp collisions at a centre-of-mass energy of 13 TeV. No significant excess over the expected background is observed. Upper limits at 95% confidence level for a massless χ˜10 are set on several electroweakino production cross-sections and the visible cross-section for beyond the Standard Model processes. In the context of simplified supersymmetric models, 95% confidence-level limits of up to 310 GeV in m(χ˜1±/χ˜20), where m(χ˜10) = 0.5 GeV, are set. Limits at 95% confidence level are also set on the χ˜1±χ˜20 cross-section in the mass plane of m(χ˜1±/χ˜20) and m(χ˜10), and on scenarios with gravitino as the lightest supersymmetric particle. Upper limits at the 95% confidence-level are set on the higgsino production cross-section. Higgsino masses below 380 GeV are excluded for the case of the higgsino fully decaying into a Higgs boson and a gravitino. [Figure not available: see fulltext.] © 2020, The Author(s).
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