| 1. |
- Kim, Haesook T., et al.
(författare)
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Prognostic Score and Cytogenetic Risk Classification for Chronic Lymphocytic Leukemia Patients : Center for International Blood and Marrow Transplant Research Report
- 2019
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Ingår i: Clinical Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 1078-0432 .- 1557-3265. ; 25:16, s. 5143-5155
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To develop a prognostic model and cytogenetic risk classification for previously treated patients with chronic lymphocytic leukemia (CLL) undergoing reduced intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT).Experimental Design: We performed a retrospective analysis of outcomes of 606 patients with CLL who underwent RIC allogeneic HCT between 2008 and 2014 reported to the Center for International Blood and Marrow Transplant Research.Results: On the basis of multivariable models, disease status, comorbidity index, lymphocyte count, and white blood cell count at HCT were selected for the development of prognostic model. Using the prognostic score, we stratified patients into low-, intermediate-, high-, and very-high-risk [4-year progression-free survival (PFS) 58%, 42%, 33%, and 25%, respectively, P < 0.0001; 4-year overall survival (OS) 70%, 57%, 54%, and 38%, respectively, P < 0.0001]. We also evaluated karyotypic abnormalities together with del(17p) and found that del(17p) or >= 5 abnormalities showed inferior PFS. Using a multivariable model, we classified cytogenetic risk into low, intermediate, and high (P < 0.0001). When the prognostic score and cytogenetic risk were combined, patients with low prognostic score and low cytogenetic risk had prolonged PFS (61% at 4 years) and OS (75% at 4 years).Conclusions: In this large cohort of patients with previously treated CLL who underwent RIC HCT, we developed a robust prognostic scoring system of HCT outcomes and a novel cytogenetic-based risk stratification system. These prognostic models can be used for counseling patients, comparing data across studies, and providing a benchmark for future interventions. For future study, we will further validate these models for patients receiving targeted therapies prior to HCT.
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| 2. |
- Buganza, Tommaso, et al.
(författare)
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Storymaking and Organizational Transformation : How the Co-creation of Narratives Engages People for Innovation and Transformation
- 2023. - 1st
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- In a world undergoing continuous change, organizations find themselves facing the challenge of how to keep innovating to stay competitive. Inside any organization, people are the cornerstone on which innovation rests and builds, yet it is ever more difficult to engage everyone in designing their organization. This book explores and discusses how employees can be engaged digitally to assist innovation initiatives and lead to organizational transformation. Storymaking and Organizational Transformation is based on the research activities of the platform IDeaLs during the year 2020 and provides a perspective on how employees can be helped to understand and even contribute to organizational innovation spontaneously. The book contributes to advancing understanding of engagement from two main perspectives: first, the authors introduce an approach based on storymaking; second, six cases are studied in depth and the application of the digital storymaking approach is explained. The authors introduce new ways of organizing in a context of ongoing change, as they bring forth the idea that engagement is a continuous practice of designing meaningful narratives which connect people and evolve along with them. The book will appeal to both academics and practitioners across management fields. Scholars of innovation management and organization sciences will benefit from the extensive review of organizational transformation and innovation from a sensemaking perspective, whilst the practical, case studies provide a valuable resource for practitioners looking to effect change and manage transformation.
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| 3. |
- Magnanini, Silvia, et al.
(författare)
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IDeaLs (innovation and design as leadership) : Transformation in the digital era
- 2021. - 1st
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- As society faces significant disruptions, the need for transformative innovation has never been more vital. However, this urgency is challenged in the digital era, characterized by incessant new technologies, extreme connectivity, and data transparency. Leaders seeking transformative innovation in the digital era face a new dilemma: socially orchestrating the synchronization of ideas that simultaneously encourages collective action. IDeaLs - Innovation and Design as Leadership - was established to research this conundrum. Inspired by the actual transformation journeys of multinational companies, and based on research with 7 global companies, IDeaLs explores how re-framing our traditional theories through the lens of Humanism reveals opportunities for a more integrated approach to engaging people for systemic change. To empower innovation leaders, the dimensions of IDeaLs build a scaffold for systemic awareness and conscious intent called Design-Driven Transformation. This evolving research agenda aims to examine in-depth the potency of an integrated approach, laying a foundation for more systemic ways to engage people and transform existing situations into preferred futures.
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| 4. |
- Trabucchi, Daniel, et al.
(författare)
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Story-making to nurture change: creating a journey to make transformation happen
- 2022
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Ingår i: Journal of Knowledge Management. - : Emerald Group Publishing. - 1758-7484 .- 1367-3270. ; 26:11, s. 427-460
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Tidskriftsartikel (refereegranskat)abstract
- Purpose To overcome change management challenges, organizations often rely on stories as means of communication. Storytelling has emerged as a leading change management tool to influence and bring people on sharing knowledge. Nevertheless, this study aims to suggest stories of change as a more effective tool that helps people in taking action toward transformation processes. Design/methodology/approach The authors apply design science research to develop and evaluate how writing a prospective story engages organizational actors in the transformation process. The authors test the story-making artifact in a field study with five companies and 115 employees who participated in 75 workshops. Findings Using the findings to discuss the role of story-making in facilitating the emergence of new behaviors in transformation processes, the authors link story-making with the opportunity to make change happen through knowledge dissemination rather than merely understanding it. Research limitations/implications The authors illustrate the role of iterations, peers and self-criticism that help story-makers embrace sense-making, developing a shared knowledge based that influence individual actions. Practical implications The authors propose the story-making approach that organizations can follow to nurture change to make transformation happen through knowledge cocreation. Originality/value The research explores story-making as an individual act of writing prospective stories to facilitate the emergence of new behaviors through shared knowledge.
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