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| 2. |
- Cohen, Timothy, et al.
(författare)
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Continental aridification and the vanishing of Australia's mega-lakes
- 2011
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Ingår i: Geology. - 0091-7613 .- 1943-2682. ; 39, s. 167-170
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Tidskriftsartikel (refereegranskat)abstract
- The nature of the Australian climate at about the time of rapid megafaunal extinctions and humans arriving in Australia is poorly understood and is an important element in the contentious debate as to whether humans or climate caused the extinctions. Here we present a new paleoshoreline chronology that extends over the past 100 k.y. for Lake Mega-Frome, the coalescence of Lakes Frome, Blanche, Callabonna and Gregory, in the southern latitudes of central Australia. We show that Lake Mega-Frome was connected for the last time to adjacent Lake Eyre at 50–47 ka, forming the largest remaining interconnected system of paleolakes on the Australian continent. The fi nal disconnection and a progressive drop in the level of Lake Mega-Frome represents a major climate shift to aridifi cation that coincided with the arrival of humans and the demise of the megafauna. The supply of moisture to the Australian continent at various times in the Quaternary has commonly been ascribed to an enhanced monsoon. This study, in combination with other paleoclimate data, provides reliable evidence for peri-ods of enhanced tropical and enhanced Southern Ocean sources of water fi lling these lakes at different times during the last full glacial cycle.
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| 3. |
- Di Angelantonio, Emanuele, et al.
(författare)
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Association of Cardiometabolic Multimorbidity With Mortality : The Emerging Risk Factors Collaboration
- 2015
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Ingår i: Journal of the American Medical Association (JAMA). - : American Medical Association (AMA). - 0098-7484 .- 1538-3598. ; 314:1, s. 52-60
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE The prevalence of cardiometabolic multimorbidity is increasing.OBJECTIVE To estimate reductions in life expectancy associated with cardiometabolic multimorbidity.DESIGN, SETTING, AND PARTICIPANTS Age-and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689 300 participants; 91 cohorts; years of baseline surveys: 1960-2007; latest mortality follow-up: April 2013; 128 843 deaths). The HRs from the Emerging Risk Factors Collaboration were compared with those from the UK Biobank (499 808 participants; years of baseline surveys: 2006-2010; latest mortality follow-up: November 2013; 7995 deaths). Cumulative survival was estimated by applying calculated age-specific HRs for mortality to contemporary US age-specific death rates. EXPOSURES A history of 2 or more of the following: diabetes mellitus, stroke, myocardial infarction (MI).MAIN OUTCOMES AND MEASURES All-cause mortality and estimated reductions in life expectancy.RESULTS In participants in the Emerging Risk Factors Collaboration without a history of diabetes, stroke, or MI at baseline (reference group), the all-cause mortality rate adjusted to the age of 60 years was 6.8 per 1000 person-years. Mortality rates per 1000 person-years were 15.6 in participants with a history of diabetes, 16.1 in those with stroke, 16.8 in those with MI, 32.0 in those with both diabetes and MI, 32.5 in those with both diabetes and stroke, 32.8 in those with both stroke and MI, and 59.5 in those with diabetes, stroke, and MI. Compared with the reference group, the HRs for all-cause mortality were 1.9 (95% CI, 1.8-2.0) in participants with a history of diabetes, 2.1 (95% CI, 2.0-2.2) in those with stroke, 2.0 (95% CI, 1.9-2.2) in those with MI, 3.7 (95% CI, 3.3-4.1) in those with both diabetes and MI, 3.8 (95% CI, 3.5-4.2) in those with both diabetes and stroke, 3.5 (95% CI, 3.1-4.0) in those with both stroke and MI, and 6.9 (95% CI, 5.7-8.3) in those with diabetes, stroke, and MI. The HRs from the Emerging Risk Factors Collaboration were similar to those from the more recently recruited UK Biobank. The HRs were little changed after further adjustment for markers of established intermediate pathways (eg, levels of lipids and blood pressure) and lifestyle factors (eg, smoking, diet). At the age of 60 years, a history of any 2 of these conditions was associated with 12 years of reduced life expectancy and a history of all 3 of these conditions was associated with 15 years of reduced life expectancy.CONCLUSIONS AND RELEVANCE Mortality associated with a history of diabetes, stroke, or MI was similar for each condition. Because any combination of these conditions was associated with multiplicative mortality risk, life expectancy was substantially lower in people with multimorbidity.
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| 4. |
- Do, Ron, et al.
(författare)
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Common variants associated with plasma triglycerides and risk for coronary artery disease
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:11, s. 1345-
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Tidskriftsartikel (refereegranskat)abstract
- Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.
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| 5. |
- Englund, Claire, 1954-, et al.
(författare)
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Advancing cultures of innovation : The change laboratory as an intervention to facilitate agency and collaborative sustainable development among teachers in higher education
- 2018
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Ingår i: ASCILITE 2018 - Conference Proceedings - 35th International Conference of Innovation, Practice and Research in the use of Educational Technologies in Tertiary Education. - : Australasian Society for Computers in Learning in Tertiary Education (ASCILITE). ; , s. 356-361
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Konferensbidrag (refereegranskat)abstract
- To cope with the rapidly changing Higher Education climate, teachers need the agency to act proactively to initiate and steer changes to meet their needs. The results of this study indicate that transformative agency emerges when teachers are given the opportunity to analyse, envision and redesign their practice collaboratively with the help of mediating conceptual tools. This has implications for academic development, suggesting that activities providing a ‘third space’ for discussion and criticism of current practices is needed to support the development of agency thus creating a culture of innovative practice.
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| 6. |
- Englund, Claire, et al.
(författare)
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Facilitating agency : the Change Laboratory as an intervention for collaborative sustainable development in higher education
- 2018
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Ingår i: International journal for academic development. - : Taylor & Francis. - 1360-144X .- 1470-1324. ; 23:3, s. 192-205
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Tidskriftsartikel (refereegranskat)abstract
- To cope with the rapidly changing Higher Education climate, teachers need the agency to act proactively to initiate and steer changes to meet their needs. The results of this study indicate that transformative agency emerges when teachers are given the opportunity to analyse, envision and redesign their practice collaboratively with the help of mediating conceptual tools. This has implications for academic development, suggesting that activities providing a 'third space' for discussion and criticism of current practices is needed to support the development of agency.
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| 7. |
- Englund, Claire, 1954-
(författare)
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Teaching in an age of complexity : exploring academic change and development in higher education
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Higher education (HE) has expanded and diversified at an unprecedented rate over the last two decades in response to a rapidly changing educational and political climate. Change and development are omnipresent, a constant part of university teachers’ sociocultural and organisational practice at multiple levels; the micro-level, the meso-level and the macro-level Against this background, the aim of this thesis is to gain a deeper understanding of the factors that influence academic change. A further aim of the thesis is to provide insight into factors that may be relevant in the design of academic development activities to support teachers and managers in the enhancement of teaching and learning. A twelve-year longitudinal study of teachers on an online pharmacy programme forms the basis for the research, where a multilevel approach is used to investigate academic change and development in a teaching and learning environment supported by educational technology (Edtech). The approach captures the influence of factors such as conceptions and approaches to teaching at the micro-level of the individual teacher, as well as the influence of systemic factors such as the sociocultural context at the meso-level of the department or programme and the structural context at the macro-level of the institution.To explore and understand the complexity of change and development in academic practice at micro-, meso- and macro-level two theoretical frameworks are used: conceptions of and approaches to teaching (CAT), and Cultural-Historical Activity Theory (CHAT). An interventionist method based on the tenets of CHAT was also employed. Data analysed in the thesis includes interviews with teachers (n=57), observations (n=27 hours), student evaluation surveys (n=30) and document analysis (n=11) collected over a 12-year timespan (2004-2016). The analysis indicated that at the micro-level a critical factor in the choice and use of Edtech is the underlying conception of and approach to teaching and learning of the teacher. Opportunities for change and development were found to be facilitated by the sociocultural context at the meso-level of the department, where support from the community and mediating tools for communication were present, but could also be hindered when this was lacking. At macro-level, institutional policy and strategy documents were seen to impede change and development, where research is consistently prioritised over teaching. At the meso-level of the department or programme, the opportunity to work together as a team to collaboratively construct and develop practice was found to be of significance in the development of agency and academic practice.Taking into account a combined analysis of the five papers included, it can be concluded that if a deeper understanding of academic change and development is to be achieved, it is necessary to adopt a holistic approach, considering factors at micro-, meso- and macro-level and the interrelationships between these factors. This thesis discusses the consequences of the research for the facilitation of academic change and development. A multilevel, holistic approach is suggested, building on the principles of the Scholarship of Teaching and Learning (SoTL) model. SoTL initiatives at all levels should be aligned to promote academic change and development through: the development of teachers’ individual practice at micro-level, the collaborative development of scholarly practice at the meso-level of the department and a strategic institutional approach at macro-level linking SoTL to employment and promotion frameworks and the recognition of teaching quality.The main contribution of this thesis lies in the adoption of a holistic approach to understanding academic practice in higher education, taking into consideration factors at micro-, meso- and macro-level and the interrelationships between these factors.
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| 8. |
- Englund, Claire, et al.
(författare)
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Teaching with technology in higher education : understanding conceptual change and development in practice
- 2017
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Ingår i: Higher Education Research and Development. - : Routledge. - 0729-4360 .- 1469-8366. ; 36:1, s. 73-87
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Tidskriftsartikel (refereegranskat)abstract
- Research indicates that teachers’ conceptions of and approaches to teaching with technology are central for the successful implementation of educational technologies in higher education. This study advances this premise. We present a 10-year longitudinal study examining teachers’ conceptions of and approaches to teaching and learning with technology. Nine teachers on an online Bachelor of Science in Pharmacy and a Master of Pharmacy programme at a Swedish university were studied using a phenomenographic approach. Results showed clear differences between novice and experienced teachers. Although novice teachers initially held more teacher-focused conceptions, they demonstrated greater and more rapid change than experienced colleagues. Experienced teachers tended to exhibit little to no change in conceptions. Supporting conceptual change should, therefore, be a central component of professional development activities if a more effective use of educational technology is to be achieved.
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| 9. |
- Englund, Claire, et al.
(författare)
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The influence of sociocultural and structural contexts in academic change and development in higher education
- 2018
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Ingår i: Higher Education. - : Springer. - 0018-1560 .- 1573-174X. ; 76:6, s. 1051-1069
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Tidskriftsartikel (refereegranskat)abstract
- Teaching quality improvements frequently focus upon the ‘development’ of individual academics in higher education. However, research also shows that the academics’ context has considerable influence upon their practices. This study examines the working environments of teachers on an online pharmacy programme, investigating contextual conditions that facilitate or impede academic change and development. Interview data and institutional policy documents are examined within a Cultural-Historical Activity Theory framework. Distinct differences in the teachers’ sociocultural context were identified as influencing change and development. Departmental teaching cultures and patterns of communication influenced practice both positively, by offering collegial support, and negatively by impeding change. The findings have significance for academic development strategies. They suggest that departmental-level support should include communicative pathways that promote reflection upon and development of conceptions of teaching and learning.
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| 10. |
- Ikram, M. Arfan, et al.
(författare)
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Common variants at 6q22 and 17q21 are associated with intracranial volume
- 2012
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:5, s. 539-544
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Tidskriftsartikel (refereegranskat)abstract
- During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.
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