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- 2019
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Tidskriftsartikel (refereegranskat)
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- Price, T. Douglas, et al.
(författare)
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Human remains, context, and place of origin for the Salme, Estonia, boat burials
- 2020
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Ingår i: Journal of Anthropological Archaeology. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0278-4165 .- 1090-2686. ; 58
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Tidskriftsartikel (refereegranskat)abstract
- Isotopic proveniencing of all individuals from the ship and boat burials at Salme, Estonia, is the subject of this study of the interred human remains from around AD 750, at the beginning of the Viking period. The isotopic results indicate that the majority of these individuals came from a region with higher strontium isotopic ratios than those found in Estonia. There were five individuals, buried in Salme II-the ship burial with 34 individuals-who exhibited lower strontium isotope ratios that might have come from the Swedish island of Gotland or several other possible places. The combination of isotopic signals and archaeological information suggests that the majority of buried individuals (those with higher strontium isotope ratios) came from the Malaren Valley in east-central Sweden.
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| 3. |
- Abou-Zeid, Nancy, et al.
(författare)
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Towards a cancer mission in Horizon Europe: recommendations
- 2020
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Ingår i: Molecular Oncology. - : Wiley Open Access. - 1878-0261 .- 1574-7891. ; 14:8, s. 1589-1615
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Tidskriftsartikel (refereegranskat)abstract
- A comprehensive translational cancer research approach focused on personalized and precision medicine, and covering the entire cancer research–care–prevention continuum has the potential to achieve in 2030 a 10-year cancer-specific survival for 75% of patients diagnosed in European Union (EU) member states with a well-developed healthcare system. Concerted actions across this continuum that spans from basic and preclinical research through clinical and prevention research to outcomes research, along with the establishment of interconnected high-quality infrastructures for translational research, clinical and prevention trials and outcomes research, will ensure that science-driven and social innovations benefit patients and individuals at risk across the EU. European infrastructures involving comprehensive cancer centres (CCCs) and CCC-like entities will provide researchers with access to the required critical mass of patients, biological materials and technological resources and can bridge research with healthcare systems. Here, we prioritize research areas to ensure a balanced research portfolio and provide recommendations for achieving key targets. Meeting these targets will require harmonization of EU and national priorities and policies, improved research coordination at the national, regional and EU level and increasingly efficient and flexible funding mechanisms. Long-term support by the EU and commitment of Member States to specialized schemes are also needed for the establishment and sustainability of trans-border infrastructures and networks. In addition to effectively engaging policymakers, all relevant stakeholders within the entire continuum should consensually inform policy through evidence-based advice.
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| 7. |
- Alkarp, Magnus, et al.
(författare)
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Tempel av guld eller kyrka av trä? : markradarundersökningar vid Gamla Uppsala kyrka
- 2006
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Ingår i: Fornvännen: meddelanden från K. Vitterhets, historie och antikvitets akademien. - 0015-7813. ; :1, s. 261-272
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Tidskriftsartikel (refereegranskat)abstract
- In 1164 the "archbishopric of Sweden" was established at "Gamla Uppsala", once the political centre of the "Svear kingdom" in the late Iron Age and a stronghold of pre-Christian cult. This highly symbolic decision was manifested through the construction of one of the largest churches in Scandinavia.The cathedral church at Gamla Uppsala was allegedly built on the same spot as the famous "pagan temple2 described by "Adam of Bremen" in the early 1070s. Excavations carried out there in 1926 revealed a highly complex stratigraphic sequence and a confusing set of postholes that were immediately interpreted as the remains of the temple. Though still maintained today in school textbooks and elsewhere, this conclusion is clearly erroneous as the postholes can be shown stratigraphically to belong to different phases of construction.The exact events of the period c. 1050-1150 in Gamla Uppsala have never been satisfactorily understood, but there is clear evidence to suggest that the cathedral was by no means the first church to have been built on the site. In an effort to elucidate this early history of the church plateau, in 2003-04 the authors examined the area with ground-penetrating radar. In this paper we discuss some of the more important results of these investigations.
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- Beecham, Ashley H, et al.
(författare)
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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
- 2013
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:11, s. 1353-60
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Tidskriftsartikel (refereegranskat)abstract
- Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 × 10(-8)), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
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| 10. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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