| 4. |
- Papadopoulos, N G, et al.
(författare)
-
Viruses and bacteria in acute asthma exacerbations - A GA(2) LEN-DARE* systematic review.
- 2010
-
Ingår i: Allergy. - : Wiley. - 1398-9995 .- 0105-4538.
-
Forskningsöversikt (refereegranskat)abstract
- To cite this article: Papadopoulos NG, Christodoulou I, Rohde G, Agache I, Almqvist C, Bruno A, Bonini S, Bont L, Bossios A, Bousquet J, Braido F, Brusselle G, Canonica GW, Carlsen KH, Chanez P, Fokkens WJ, Garcia-Garcia M, Gjomarkaj M, Haahtela T, Holgate ST, Johnston SL, Konstantinou G, Kowalski M, Lewandowska-Polak A, Lødrup-Carlsen K, Mäkelä M, Malkusova I, Mullol J, Nieto A, Eller E, Ozdemir C, Panzner P, Popov T, Psarras S, Roumpedaki E, Rukhadze M, Stipic-Markovic A, Todo Bom A, Toskala E, van Cauwenberge P, van Drunen C, Watelet JB, Xatzipsalti M, Xepapadaki P, Zuberbier T. Viruses and bacteria in acute asthma exacerbations - A GA(2) LEN-DARE systematic review. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02505.x. ABSTRACT: A major part of the burden of asthma is caused by acute exacerbations. Exacerbations have been strongly and consistently associated with respiratory infections. Respiratory viruses and bacteria are therefore possible treatment targets. To have a reasonable estimate of the burden of disease induced by such infectious agents on asthmatic patients, it is necessary to understand their nature and be able to identify them in clinical samples by employing accurate and sensitive methodologies. This systematic review summarizes current knowledge and developments in infection epidemiology of acute asthma in children and adults, describing the known impact for each individual agent and highlighting knowledge gaps. Among infectious agents, human rhinoviruses are the most prevalent in regard to asthma exacerbations. The newly identified type-C rhinoviruses may prove to be particularly relevant. Respiratory syncytial virus and metapneumovirus are important in infants, while influenza viruses seem to induce severe exacerbations mostly in adults. Other agents are relatively less or not clearly associated. Mycoplasma and Chlamydophila pneumoniae seem to be involved more with asthma persistence rather than with disease exacerbations. Recent data suggest that common bacteria may also be involved, but this should be confirmed. Although current information is considerable, improvements in detection methodologies, as well as the wide variation in respect to location, time and populations, underline the need for additional studies that should also take into account interacting factors.
|
|
| 5. |
- Gray, I., et al.
(författare)
-
A novel approach for the autonomous inspection and repair of aircraft composite structures
- 2019
-
Ingår i: <em>18<sup>th</sup> European Conference on Composite Materials </em>(ECCM). - : Applied Mechanics Laboratory.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The paper presents the results obtained in the first two years of the H2020 CompInnova project which deals with the development of an innovative approach for inspection and repair of damage in aeronautical composites. The development of a newly designed robotic platform for autonomous inspection using combined infrared thermography (IRT) and phased array (PA) non-destructive investigation for damage detection and characterization, while integrated with laser repair capabilities. PA and IRT are combined in order to detect near-surface and sub-surface damages. Development of a novel thermographic technique termed Pulsed Phase-informed Lock-In Thermography, enables for the first time the rapid and quantitative assessment of damage in the materials. Furthermore, the results are fused using machine learning and image processing techniques for detection and sizing in real time. This will provide the information needed for an automatic laser repair procedure capable of removing precisely ply-by-ply the material. This method allows to have a well-treated surface to apply a repair patch. The three different modules (PA, IRT and laser repair) are integrated on an autonomous robotic platform. The robot is going to be able to attach and move on surfaces of different orientations via the use of a vortex-based actuation system, thus providing the ability to autonomously access, scan and repair the different sections of an aircraft fuselage. © CCM 2020 - 18th European Conference on Composite Materials. All rights reserved.
|
|
