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- Papadopoulos, N G, et al.
(författare)
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Viruses and bacteria in acute asthma exacerbations - A GA(2) LEN-DARE* systematic review.
- 2010
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Ingår i: Allergy. - : Wiley. - 1398-9995 .- 0105-4538.
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Forskningsöversikt (refereegranskat)abstract
- To cite this article: Papadopoulos NG, Christodoulou I, Rohde G, Agache I, Almqvist C, Bruno A, Bonini S, Bont L, Bossios A, Bousquet J, Braido F, Brusselle G, Canonica GW, Carlsen KH, Chanez P, Fokkens WJ, Garcia-Garcia M, Gjomarkaj M, Haahtela T, Holgate ST, Johnston SL, Konstantinou G, Kowalski M, Lewandowska-Polak A, Lødrup-Carlsen K, Mäkelä M, Malkusova I, Mullol J, Nieto A, Eller E, Ozdemir C, Panzner P, Popov T, Psarras S, Roumpedaki E, Rukhadze M, Stipic-Markovic A, Todo Bom A, Toskala E, van Cauwenberge P, van Drunen C, Watelet JB, Xatzipsalti M, Xepapadaki P, Zuberbier T. Viruses and bacteria in acute asthma exacerbations - A GA(2) LEN-DARE systematic review. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02505.x. ABSTRACT: A major part of the burden of asthma is caused by acute exacerbations. Exacerbations have been strongly and consistently associated with respiratory infections. Respiratory viruses and bacteria are therefore possible treatment targets. To have a reasonable estimate of the burden of disease induced by such infectious agents on asthmatic patients, it is necessary to understand their nature and be able to identify them in clinical samples by employing accurate and sensitive methodologies. This systematic review summarizes current knowledge and developments in infection epidemiology of acute asthma in children and adults, describing the known impact for each individual agent and highlighting knowledge gaps. Among infectious agents, human rhinoviruses are the most prevalent in regard to asthma exacerbations. The newly identified type-C rhinoviruses may prove to be particularly relevant. Respiratory syncytial virus and metapneumovirus are important in infants, while influenza viruses seem to induce severe exacerbations mostly in adults. Other agents are relatively less or not clearly associated. Mycoplasma and Chlamydophila pneumoniae seem to be involved more with asthma persistence rather than with disease exacerbations. Recent data suggest that common bacteria may also be involved, but this should be confirmed. Although current information is considerable, improvements in detection methodologies, as well as the wide variation in respect to location, time and populations, underline the need for additional studies that should also take into account interacting factors.
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- Bossios, Apostolos, 1969, et al.
(författare)
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Rhinovirus infection and house dust mite exposure synergize in inducing bronchial epithelial cell interleukin-8 release.
- 2008
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Ingår i: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. - : Wiley. - 1365-2222. ; 38:10, s. 1615-26
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Human rhinoviruses (HRVs) and house dust mites (HDMs) are among the most common environmental factors able to induce airway inflammation in asthma. Although epidemiological studies suggest that they also synergize in inducing asthma exacerbations, there is no experimental evidence to support this, nor any information on the possible mechanisms involved. OBJECTIVE: To investigate their interaction on the induction of airway epithelial inflammatory responses in vitro. METHODS: BEAS-2B cells were exposed to activated HDM Dermatophagoides pteronyssinus major allergen I (Der p I), HRVs (HRV1b or HRV16) or both in different sequences. IL-8/CXCL8 release, intercellular adhesion molecule (ICAM)-1 surface expression and nuclear factor kappaB (NF-kappaB) translocation were evaluated. Complementary, primary human bronchial epithelial cells (HBECs) exposed to both Der p I and RVs and IL-8, IL-6, IFN-gamma-induced protein (IP)-10/CXCL10, IFN-lambda1/IL-29, regulated upon activation normal T lymphocyte expressed and secreted (RANTES)/CCL5 release were measured. RESULTS: RV and Der p I up-regulated IL-8 release, ICAM-1 expression and NF-kappaB translocation in BEAS-2B cells. Simultaneous exposure to both factors, as well as when cells were initially exposed to HRV and then to Der p I, resulted in further induction of IL-8 in a synergistic manner. Synergism was not observed when cells were initially exposed to Der p I and then to HRV. This was the pattern in ICAM-1 induction although the phenomenon was not synergistic. Concurrent exposure induced an early synergistic NF-kappaB translocation induction, differentiating with time, partly explaining the above observation. In HBECs, both HRV and Der p I induced IL-8, IL-6, IL-29 and IP-10, while RANTES was induced only by HRV. Synergistic induction was observed only in IL-8. CONCLUSION: HRV and enzymatically active Der p I can act synergistically in the induction of bronchial epithelial IL-8 release, when HRV infection precedes or is concurrent with Der p I exposure. Such a synergy may represent an important mechanism in virus-induced asthma exacerbations.
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- Gray, I., et al.
(författare)
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A novel approach for the autonomous inspection and repair of aircraft composite structures
- 2019
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Ingår i: <em>18<sup>th</sup> European Conference on Composite Materials </em>(ECCM). - : Applied Mechanics Laboratory.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The paper presents the results obtained in the first two years of the H2020 CompInnova project which deals with the development of an innovative approach for inspection and repair of damage in aeronautical composites. The development of a newly designed robotic platform for autonomous inspection using combined infrared thermography (IRT) and phased array (PA) non-destructive investigation for damage detection and characterization, while integrated with laser repair capabilities. PA and IRT are combined in order to detect near-surface and sub-surface damages. Development of a novel thermographic technique termed Pulsed Phase-informed Lock-In Thermography, enables for the first time the rapid and quantitative assessment of damage in the materials. Furthermore, the results are fused using machine learning and image processing techniques for detection and sizing in real time. This will provide the information needed for an automatic laser repair procedure capable of removing precisely ply-by-ply the material. This method allows to have a well-treated surface to apply a repair patch. The three different modules (PA, IRT and laser repair) are integrated on an autonomous robotic platform. The robot is going to be able to attach and move on surfaces of different orientations via the use of a vortex-based actuation system, thus providing the ability to autonomously access, scan and repair the different sections of an aircraft fuselage. © CCM 2020 - 18th European Conference on Composite Materials. All rights reserved.
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- Kantarelis, Efthymios, PhD, 1982-, et al.
(författare)
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Engineering the Catalytic Properties of HZSM5 by Cobalt Modification and Post-synthetic Hierarchical Porosity Development
- 2019
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Ingår i: Topics in catalysis. - : Springer Science and Business Media LLC. - 1022-5528 .- 1572-9028. ; 62:7, s. 773-785
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Tidskriftsartikel (refereegranskat)abstract
- Hierarchical zeolites have been identified as special catalytic materials with improved catalytic properties. In this study, hierarchical bifunctional ZSM5 based catalysts were prepared by desilication for controlled mesoporosity development and have been modified by Co doping. Their performance in the catalytic pyrolysis of oak in a lab scale reactor was evaluated. Desilicated counterparts were proven more active in deoxygenation of bio oil, while carbon deposition on the catalysts reduced compared to non-desilicated counterparts. Increased Lewis acidity favors decarboxylation reactions, while higher olefins as well as PAH content indicate easier diffusion within and from the porous network and interactions in the mesopores. The conversion of bulky lignin molecules (alkoxy phenols) is enhanced by the mesopores, while acidity is of secondary importance. Coke deposition inside the pores is more profound in the desilicated catalysts due to larger pore size. Carbon deposition on the catalysts is reduced in the following order: HZSM5 > Co/HZSM5 > Ds-HZSM5 > Co/Ds-HZSM5. GC–MS characterization of the CH2Cl2 soluble coke indicated that for the desilicated counterparts the main coke precursors are the bulky lignin molecules which are partially deoxygenated.
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| 8. |
- Kostopoulos, V., et al.
(författare)
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Autonomous Inspection and Repair of Aircraft Composite Structures
- 2018
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Ingår i: 18th IFAC Conference on Technology, Culture and International Stability TECIS 2018. - : Elsevier. ; , s. 554-557, s. 554-557
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Konferensbidrag (refereegranskat)abstract
- This paper deals with the development of an innovative approach for inspection and repair of damage in aeronautical composites that took place in the first two years of the H2020 Compinnova project which. The aim is a newly designed robotic platform for autonomous inspection using combined infrared thermography (IRT) and phased array (PA) non-destructive investigation for damage detection and characterization, while integrated with laser repaircapabilities. This will affect the increasing societal need for safer aircraft in the lowest possible cost, while new and effective techniques of inspection are needed because of the rapidly expanding use of composites in the aerospace industry.
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| 9. |
- Manika, Georgia, 1986, et al.
(författare)
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On the Ferroelectric to Paraelectric Structural Transition of BaTiO 3 Micro-/Nanoparticles and Their Epoxy Nanocomposites
- 2020
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Ingår i: Molecules. - : MDPI AG. - 1420-3049 .- 1420-3049. ; 25:11
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Tidskriftsartikel (refereegranskat)abstract
- BaTiO3 is one of the most widely used ceramic components in capacitor formulation due to its exceptional ferroelectric properties. The structural transition from the ferroelectric tetragonal to the paraelectric cubic phase has been studied in both nano- and micro-BaTiO3 particles. Several experimental techniques were employed for characterization purposes (X-ray diffraction-XRD, laser Raman spectroscopy-LRS, differential scanning calorimetry-DSC and broadband dielectric spectroscopy-BDS). All gave evidence for the structural transition from the polar tetragonal to the non-polar cubic phase in both nano- and micro-BaTiO3 particles. Variation of Full Width at Half Maximum (FWHM) with temperature in XRD peaks was employed for the determination of the critical Curie temperature (Tc). In micro-BaTiO3 particles (Tc) lies close to 120 °C, while in nanoparticles the transition is complicated due to the influence of particles' size. Below (Tc) both phases co-exist in nanoparticles. (Tc) was also determined via the temperature dependence of FWHM and found to be 115 °C. DSC, LRS and BDS provided direct results, indicating the transition in both nano- and micro-BaTiO3 particles. Finally, the 15 parts per hundred resin per weight (phr) BaTiO3/epoxy nanocomposite revealed also the transition through the peak formation at approximately 130 °C in the variation of FWHM with temperature. The present work introduces, for the first time, a qualitative tool for the determination and study of the ferroelectric to paraelectric structural transition in both nano- and micro-ferroelectric particles and in their nanocomposites. Moreover, its novelty lies on the effect of crystals' size upon the ferroelectric to the paraelectric phase transition and its influence on physical properties of BaTiO3.
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