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1.	Albshesh, Ahmad, et al. (författare) Effectiveness of Third-Class Biologic Treatment in Crohn's Disease : A Multi-Center Retrospective Cohort Study 2021 Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 10:13 Tidskriftsartikel (refereegranskat)abstract Background: Multiple studies have described the effectiveness of ustekinumab (UST) and vedolizumab (VDZ) in patients with Crohn's disease (CD) failing anti- Tumor necrosis factors (TNFs); however, the effectiveness of VDZ or UST as a third-class biologic has not yet been described.Aims and Methods: In this retrospective multicenter cohort study, we aimed to investigate the effectiveness of VDZ and UST as a third-class biologic in patients with CD.Results: Two-hundred and four patients were included; 156/204 (76%) patients received VDZ as a second- and UST as a third-class therapy (group A); the remaining 48/204 (24%) patients received UST as a second- and VDZ as a third-class therapy (group B). At week 16-22, 87/156 (55.5%) patients and 27/48 (56.2%) in groups A and B, respectively, responded to treatment (p = 0.9); 41/156 (26.2%) and 15/48 (31.2%) were in clinical remission (p = 0.5). At week 52; 89/103 (86%) patients and 25/29 (86.2%) of the patients with available data had responded to third-class treatment in groups A and B, respectively (p = 0.9); 31/103 (30%) and 47/29 (24.1%) were in clinical remission (p = 0.5).Conclusion: Third-class biological therapy was effective in more than half of the patients with CD. No differences in effectiveness were detected between the use of VDZ and UST as a third-class agent.

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Författare/redaktör: Raine, Tim (1); Armuzzi, Alessandro (1); Burisch, Johan (1); Gisbert, Javier P. (1); Kopylov, Uri (1); Magro, Fernando (1); visa fler...; Yanai, Henit (1); Albshesh, Ahmad (1); Taylor, Joshua (1); Savarino, Edoardo, V (1); Truyens, Marie (1); Ribaldone, Davide G. (1); Shitrit, Ariella Bar ... (1); Fibelman, Morine (1); Molander, Pauliina (1); Liefferinckx, Claire (1); Nancey, Stephane (1); Korani, Mohamed (1); Rutka, Mariann (1); Barreiro-de Acosta, ... (1); Domislovic, Viktor (1); Suris, Gerard (1); Eriksson, Carl, 1981 ... (1); Alves, Catarina (1); Mpitouli, Afroditi (1); di Jiang, Caroline (1); Tepes, Katja (1); Coletta, Marina (1); Foteinogiannopoulou, ... (1); Amir-Barak, Hadar (1); Attauabi, Mohamed (1); Seidelin, Jakob (1); Afif, Waqqas (1); Marinelli, Carla (1); Lobaton, Triana (1); Pugliese, Daniela (1); Maharshak, Nitsan (1); Cremer, Anneline (1); Limdi, Jimmy K. (1); Molnár, Tamás (1); Otero-Alvarin, Borja (1); Krznaric, Zeljko (1); Karmiris, Konstantin ... (1); Drobne, David (1); Koutroubakis, Ioanni ... (1); Chaparro, Maria (1); visa färre...

Lärosäte: Örebro universitet (1)

Språk: Engelska (1)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (1)

År: 2021 (1)

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