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- Honjo, Yasuyuki, et al.
(författare)
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TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma
- 2007
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Ingår i: Cell Cycle. - 1551-4005. ; 6:11, s. 1360-1366
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Tidskriftsartikel (refereegranskat)abstract
- We generated a mouse model with a conditional deletion of TGF-beta signaling in the neurons by crossing TGF-beta receptor I (T beta RI) floxed mice with neurofilament-H (NF-H) Cre mice. 35% of F1 conditional knockout (COKO) mice developed spontaneous squamous cell carcinomas (SCCs) in periorbital and/ or perianal regions. Transplantation of these tumors into athymic nude mice resulted in 62% tumorigenicity. To determine whether evasion of the immune response plays any role in this tumorigenesis, we analyzed the expression levels of receptors for interleukin-13 (mIL-13R), a key negative regulator of tumor immunosurveillance, and found that 33% of COKO tumors expressed the IL-13R alpha 2 chain. Primary cultures of the SCCs expressing IL-13R alpha 2 were sensitive to the cytotoxic effect of IL-13R-directed cytotoxin treatment. This is the first demonstration that loss of T beta RI can lead to spontaneous tumor formation. These mice can serve as a unique mouse model of SCC to evaluate the tumorigenicity and effect of anti-cancer therapeutics.
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| 2. |
- Martin, Gary, et al.
(författare)
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Methods to Assess Ethnoecological Knowledge Acquistion, Distribution and Transmission : Species complexes and complex species
- 2006
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Ingår i: Program of 10th International Congress of Ethnobiology.
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Konferensbidrag (populärvet., debatt m.m.)abstract
- We would like to take on the Thursday afternoon workshop on acquisition and transmission of knowledge. We will present methods of data gathering and analysis used by ethnoecologists, based on courses that we have given in various institutions and field projects around the world. We plan to select confirmed participants in the ICE as speakers/presenters, so we cannot give a list of speakers until we know who is coming. We expect to invite people like Viki Reyes Garcia, Tony Cunningham and others.
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