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Träfflista för sökning "WFRF:(Quan Shangkun) "

Search: WFRF:(Quan Shangkun)

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  • Yang, Anning, et al. (author)
  • Homocysteine accelerates hepatocyte autophagy by upregulating TFEB via DNMT3b-mediated DNA hypomethylation
  • 2023
  • In: Acta Biochimica et Biophysica Sinica. - : China Science Publishing & Media Ltd.. - 1672-9145. ; 55:8, s. 1184-1192
  • Journal article (peer-reviewed)abstract
    • Autophagy plays a critical role in the physiology and pathophysiology of hepatocytes. High level of homocysteine (Hcy) promotes autophagy in hepatocytes, but the underlying mechanism is still unknown. Here, we investigate the relationship between Hcy-induced autophagy level and the expression of nuclear transcription factor EB (TFEB). The results show that Hcy-induced autophagy level is mediated by upregulation of TFEB. Silencing of TFEB decreases the level of autophagy-related protein LC3BII/I and increases p62 expression level in hepatocytes after exposure to Hcy. Moreover, the effect of Hcy on the expression of TFEB is regulated by hypomethylation of the TFEB promoter catalyzed by DNA methyltransferase 3b (DNMT3b). In summary, this study shows that Hcy can activate autophagy by inhibiting DNMT3b-mediated DNA methylation and upregulating TFEB expression. These findings provide another new mechanism for Hcy-induced autophagy in hepatocytes.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Liu, Bin (1)
Sun, Jianmin (1)
Sun, Yue (1)
Zhang, Hongwen (1)
Wang, Qingqing (1)
Ding, Ning (1)
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Zeng, Wen (1)
Wu, Kai (1)
Yang, Xiaoling (1)
Zhang, Huiping (1)
Jiang, Yideng (1)
Yang, Anning (1)
Hao, Yinju (1)
Quan, Shangkun (1)
Jiao, Yun (1)
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University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2023 (1)

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