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- Karlsson, Elinor K, et al.
(författare)
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Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B
- 2013
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Ingår i: Genome Biology. - : Springer Science and Business Media LLC. - 1465-6906 .- 1474-760X .- 1474-7596. ; 14:12
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Canine osteosarcoma is clinically nearly identical to the human disease, but is common and highly heritable, making genetic dissection feasible.RESULTS: Through genome-wide association analyses in three breeds (greyhounds, Rottweilers, and Irish wolfhounds), we identify 33 inherited risk loci explaining 55% to 85% of phenotype variance in each breed. The greyhound locus exhibiting the strongest association, located 150 kilobases upstream of the genes CDKN2A/B, is also the most rearranged locus in canine osteosarcoma tumors. The top germline candidate variant is found at a >90% frequency in Rottweilers and Irish wolfhounds, and alters an evolutionarily constrained element that we show has strong enhancer activity in human osteosarcoma cells. In all three breeds, osteosarcoma-associated loci and regions of reduced heterozygosity are enriched for genes in pathways connected to bone differentiation and growth. Several pathways, including one of genes regulated by miR124, are also enriched for somatic copy-number changes in tumors.CONCLUSIONS: Mapping a complex cancer in multiple dog breeds reveals a polygenic spectrum of germline risk factors pointing to specific pathways as drivers of disease.
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| 3. |
- Alvarez Perez, Manuel Alejandro, 1980-
(författare)
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Stochastic Planning of Smart Electricity Distribution Networks
- 2017
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The penetration of intermittent Distributed Generation (DG) brought additional uncertainty to the system operation and planning. To cope with uncertainties the Distribution System Operator (DSO) could implement several strategies. These strategies range from the inclusion of smart technologies which will increment system’s flexibility and resiliency, to improvements in forecasting, modeling, and regulatory pledge that will facilitate the planning activity. Regardless of the nature of the solutions, they could be collected in a sort of toolbox. The planner will access the toolbox to conform cost effective plans, better able to deal with any uncertainty. The present work will address the problem of distribution system planning under uncertainties, considering smart solutions along with traditional reinforcements, in the short-term lead time up to 3 years ahead. The work will be focused on three aspects that are the cornerstones of this work: • A planning facilitating strategy: Distribution Capacity Contracts (DCCs). • A flexibility enabler technology: Energy Storage. • A binding methodology: Multistage Stochastic Programming. Stochastic dual dynamic programming (SDDP). Under the present directive of the European Parliament concerning common rules for the internal market in electricity, distribution companies are not allowed to own DG but entitled to include it as a planning option to differ investment in traditional grid reinforcements. An evaluation of the regulatory context will lead this work to consider DCCs as a planning alternative available in the toolbox. The impact of this type of contract on the remuneration of the DG owner will be assessed in order to provide insight on its willingness to participate. The DCCs might aid the DSO to defer grid i ii investments during planning stages and to control the network flows during operation. Given that storage solutions help to match in time production from intermittent sources with load consumption, they will play a major role in dealing with uncertainties. A generic storage model (GSM) based on a future cost piecewise approximation will be developed. This model inspired by hydro-reservoirs will help assessing the impact of storage in planning decisions. This model will be tested by implementing it in short-term hydro scheduling and unit commitment studies. To trace a path towards the future of this research work, a discussion on the planning problem formulation, under consideration of the lead time, the expansion options, the smart strategies, and the regulatory framework will be presented. Special focus will be given to multistage stochastic programming methods and in particular to the SDDP approach.
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| 5. |
- Busatto, Tatiano, et al.
(författare)
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Stability Analysis of PFC Converters Under Different Source Impedances and Its Consequences on Zero-Crossing Distortion
- 2022
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Ingår i: IEEE Transactions on Power Delivery. - : IEEE. - 0885-8977 .- 1937-4208. ; 37:4, s. 3235-3244
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Tidskriftsartikel (refereegranskat)abstract
- In the presence of multiple power converters in a power system the total current may exhibit zero-crossing distortion in the form of recurrent damped oscillations with high magnitude. These oscillations are synchronized with the power system frequency. This paper presents a comprehensive analysis of the input current of single-phase ac-dc converters fitted with power factor correction (PFC) controllers. Emphasis is given on the impacts of the source impedance, and on how the number of converters connected to a common coupling point (PCC) impacts the PFC controller’s performance. A system model is developed followed by simulation and measurements in a real installation with electronic ballasts used to drive fluorescent lighting tubes. Results show that the recurrent damped oscillations originating from PFC controllers are close to the harmonic range and with a very low level of cancellation between devices. The magnitude therefore increases proportionally with the number of devices. As the source impedance increases, instability may occur. Possible explanations for these observations are discussed.
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| 7. |
- de Oliveira, Roger Alves, et al.
(författare)
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Deep Learning Method With Manual Post-Processing for Identification of Spectral Patterns of Waveform Distortion in PV Installations
- 2021
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Ingår i: IEEE Transactions on Smart Grid. - : IEEE. - 1949-3053 .- 1949-3061. ; 12:6, s. 5444-5456
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Tidskriftsartikel (refereegranskat)abstract
- This paper proposes a deep learning (DL) method for the identification of spectral patterns of timevarying waveform distortion in photovoltaic (PV) installations. The PQ big data with information on harmonic and/or interharmonics in PV installations is handled by a deep autoencoder followed by feature clustering. Measurements of voltage and current from four distinct PV installations are used to illustrate the method. This paper shows that the DL method can be used as a starting point for further data analysis. The main contributions of the paper include: (a) providing a novel DL method for finding patterns in spectra; (b) guiding the manual post-processing based on the patterns found by the DL method; and (c) obtaining information about the emission from four PV installations.
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| 8. |
- de Oliveira, Roger Alves, et al.
(författare)
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Third Harmonic and its Relation to Solar Elevation Angle in a PV Installation with Solar Tracking Systems
- 2022
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Ingår i: 2022 20th International Conference on Harmonics & Quality of Power (ICHQP) Proceedings. - : IEEE.
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Konferensbidrag (refereegranskat)abstract
- This paper shows an application of a deep learning method to a solar installation with a solar tracking system. The method consists of a deep autoencoder followed by clustering. The deep learning method allows defining the most dominant component in harmonic spectra during long-term measurements. Power Quality measurements were accessed over two years in 3ϕ PV installation of 6 kVA with 2-axis tracking in northern Sweden. The deep learning results indicate that the third harmonic of current is the component that changes most over the two years. This paper demonstrates that there is a correlation between the daily and seasonal variations of the third harmonic with the solar elevation angle at the location. The main conclusion for this cause was associated with the operation of the solar tracking systems which are based on single-phase motors. The paper also discusses the possibility of correlation of the third harmonic with cloud coverage, snow on the panels, and reactive power unbalance.
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| 9. |
- De Souza Salles, Rafael, et al.
(författare)
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Interharmonic Analysis for Static Frequency Converter Station Supplying a Swedish Catenary System
- 2022
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Ingår i: 2022 20th International Conference on Harmonics & Quality of Power (ICHQP) Proceedings. - : IEEE.
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Konferensbidrag (refereegranskat)abstract
- The paper aims to present a waveform distortion analysis focused on interharmonics in measurements from a 70 kV busbar feeding a traction supply substation with four static frequency converters (SFC). The substation supplies a Swedish catenary system from 50 Hz public grid to 15 kV 16 ⅔ Hz. The paper assesses the interharmonics for different scenarios regarding the point of a connection configuration between the traction substation and the upstream grid, as well as a change in the number of SFCs connected in the substation. The IEC 61000-4-7 grouping method and spectrograms were used to illustrate the issue. The significant presence of interharmonics calls attention to the subject in railway application. The total indexes help to evaluate the broad picture of the phenomena. The work contributes to the waveform distortion and interharmonics in railway systems studies.
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| 10. |
- De Souza Salles, Rafael, et al.
(författare)
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Waveform Distortion Emission Assessment on Pantograph Measurements from Low-Frequency Railway Electrification
- 2022
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Ingår i: 2022 20th International Conference on Harmonics & Quality of Power (ICHQP) Proceedings. - : IEEE.
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Konferensbidrag (refereegranskat)abstract
- The paper aims to provide a waveform distortion assessment on pantograph current measurements. The data analyzed is regarding a 15 kV 16.7 Hz catenary system from Switzerland. The paper provides a characterization of the rolling stock emission content for different operation modes during a commercial utilization of the vehicle, approaching traditional harmonics, interharmonic and supraharmonic phenomena. In addition, the work provides an adaptation on the interharmonic processing proposed by the IEC 61000-4-7 regarding the 16.7 Hz fundamental frequency. The results contribute to the waveform distortion emission on pantograph measurements subject and railway systems investigation in general.
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