| 1. |
- Bixby, H., et al.
(författare)
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Rising rural body-mass index is the main driver of the global obesity epidemic in adults
- 2019
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 569:7755, s. 260-4
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Tidskriftsartikel (refereegranskat)abstract
- Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.
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| 2. |
- Mikkelsen, Tarjei S, et al.
(författare)
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Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7141, s. 167-177
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Tidskriftsartikel (refereegranskat)abstract
- We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive features of the opossum chromosomes provide support for recent theories about genome evolution and function, including a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation. Comparison of opossum and eutherian genomes also reveals a sharp difference in evolutionary innovation between protein-coding and non-coding functional elements. True innovation in protein-coding genes seems to be relatively rare, with lineage-specific differences being largely due to diversification and rapid turnover in gene families involved in environmental interactions. In contrast, about 20% of eutherian conserved non-coding elements (CNEs) are recent inventions that postdate the divergence of Eutheria and Metatheria. A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation.
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| 3. |
- Nawaz, Muhammad, et al.
(författare)
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Extracellular Vesicles: Evolving Factors in Stem Cell Biology
- 2016
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Ingår i: Stem Cells International. - : Hindawi Limited. - 1687-966X .- 1687-9678. ; 2016:1073140
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Tidskriftsartikel (refereegranskat)abstract
- Stem cells are proposed to continuously secrete trophic factors that potentially serve as mediators of autocrine and paracrine activities, associated with reprogramming of the tumor microenvironment, tissue regeneration, and repair. Hitherto, significant efforts have been made to understand the level of underlying paracrine activities influenced by stem cell secreted trophic factors, as little is known about these interactions. Recent findings, however, elucidate this role by reporting the effects of stem cell derived extracellular vesicles (EVs) that mimic the phenotypes of the cells from which they originate. Exchange of genetic information utilizing persistent bidirectional communication mediated by stem cell-EVs could regulate stemness, self-renewal, and differentiation in stem cells and their subpopulations. This review therefore discusses stem cell-EVs as evolving communication factors in stem cell biology, focusing on how they regulate cell fates by inducing persistent and prolonged genetic reprogramming of resident cells in a paracrine fashion. In addition, we address the role of stem cell-secreted vesicles in shaping the tumor microenvironment and immunomodulation and in their ability to stimulate endogenous repair processes during tissue damage. Collectively, these functions ensure an enormous potential for future therapies.
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| 4. |
- Nandi, A., et al.
(författare)
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Accretion flow dynamics during 1999 outburst of XTE J1859+226—modeling of broadband spectra and constraining the source mass
- 2018
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Ingår i: Astrophysics and Space Science. - : Springer Netherlands. - 0004-640X .- 1572-946X. ; 363:5
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Tidskriftsartikel (refereegranskat)abstract
- We examine the dynamical behavior of accretion flow around XTE J1859+226 during the 1999 outburst by analyzing the entire outburst data (∼166 days) from RXTE Satellite. Towards this, we study the hysteresis behavior in the hardness intensity diagram (HID) based on the broadband (3–150 keV) spectral modeling, spectral signature of jet ejection and the evolution of Quasi-periodic Oscillation (QPO) frequencies using the two-component advective flow model around a black hole. We compute the flow parameters, namely Keplerian accretion rate (m˙ d), sub-Keplerian accretion rate (m˙ h), shock location (rs) and black hole mass (Mbh) from the spectral modeling and study their evolution along the q-diagram. Subsequently, the kinetic jet power is computed as Ljetobs∼3–6×1037ergs−1 during one of the observed radio flares which indicates that jet power corresponds to 8–16% mass outflow rate from the disc. This estimate of mass outflow rate is in close agreement with the change in total accretion rate (∼14%) required for spectral modeling before and during the flare. Finally, we provide a mass estimate of the source XTE J1859+226 based on the spectral modeling that lies in the range of 5.2–7.9 M⊙ with 90% confidence.
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| 5. |
- Radhika, D., et al.
(författare)
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Broad-band spectral evolution and temporal variability of IGR J17091-3624 during its 2016 outburst : SWIFT and NuSTAR results
- 2018
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Ingår i: Astrophysics and Space Science. - : Springer. - 0004-640X .- 1572-946X. ; 363:9
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Tidskriftsartikel (refereegranskat)abstract
- We report on the 2016 outburst of the transient Galactic Black Hole candidate IGR J17091-3624 based on the observation campaign carried out with SWIFT and NuSTAR. The outburst profile, as observed with SWIFT-XRT, shows a typical 'q'-shape in the Hardness Intensity Diagram (HID). Based on the spectral and temporal evolution of the different parameters, we are able to identify all the spectral states in the q-profile of HID and the Hardness-RMS diagram (HRD). Both XRT and NuSTAR observations show an evolution of low frequency Quasi periodic oscillations (QPOs) during the low hard and hard intermediate states of the outburst rising phase. We also find mHz QPOs along-with distinct coherent class variabilities (heartbeat oscillations) with different timescales, similar to the -class (observed in GRS 1915+105). Phenomenological modelling of the broad-band XRT and NuSTAR spectra also reveals the evolution of high energy cut-off and presence of reflection from ionized material during the rising phase of the outburst. Further, we conduct the modelling of X-ray spectra of SWIFT and NuSTAR in 0.5-79 keV to understand the accretion flow dynamics based on two component flow model. From this modelling, we constrain the mass of the source to be in the range of with 90% confidence, which is consistent with earlier findings.
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| 6. |
- Richards, Stephen, et al.
(författare)
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The genome of the model beetle and pest Tribolium castaneum.
- 2008
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Ingår i: Nature. - 1476-4687. ; 452:7190, s. 949-55
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Tidskriftsartikel (refereegranskat)abstract
- Tribolium castaneum is a representative of earth’s most numerous eukaryotic order, a powerful model organism for the study of generalized insect development, and also an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved an ability to interact with a diverse chemical environment as evidenced by large expansions in odorant and gustatory receptors, as well as p450 and other detoxification enzymes. Developmental patterns in Tribolium are more representative of other arthropods than those found in Drosophila, a fact represented in gene content and function. For one, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, and some are expressed in the growth zone crucial for axial elongation in short germ development. Systemic RNAi in T. castaneum appears to use mechanisms distinct from those found in C. elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.
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| 7. |
- Sreehari, H., et al.
(författare)
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Constraining the mass of the black hole GX 339-4 using spectro-temporal analysis of multiple outbursts
- 2019
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Ingår i: Advances in Space Research. - : ELSEVIER SCI LTD. - 0273-1177 .- 1879-1948. ; 63:3, s. 1374-1386
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Tidskriftsartikel (refereegranskat)abstract
- We carried out spectro-temporal analysis of the archived data from multiple outbursts spanning over the last two decades from the black hole X-ray binary GX 339-4. In this paper, the mass of the compact object in the X-ray binary system GX 339-4 is constrained based on three indirect methods. The first method uses broadband spectral modelling with a two component flow structure of the accretion around the black hole. The broadband data are obtained from RXTE (Rossi X-ray Timing Explorer) in the range 3.0 to 150.0 keV and from Swift and NuSTAR (Nuclear Spectroscopic Telescope Array) simultaneously in the range 0.5 to 79.0 keV. In the second method, we model the time evolution of Quasi-periodic Oscillation (QPO) frequencies, considering it to be the result of an oscillating shock that radially propagates towards or away from the compact object. The third method is based on scaling a mass dependent parameter from an empirical model of the photon index (Gamma) - QPO (v) correlation. We compare the results at 90 percent confidence from the three methods and summarize the mass estimate of the central object to be in the range 8.28-11.89M(circle dot).
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| 8. |
- Sreehari, H., et al.
(författare)
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Observational aspects of outbursting black hole sources : Evolution of spectro-temporal features and X-ray variability
- 2018
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Ingår i: Journal of astrophysics and astronomy. - : Indian Academy of Sciences. - 0250-6335 .- 0973-7758. ; 39:1
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Tidskriftsartikel (refereegranskat)abstract
- We report on our attempt to understand the outbursting profile of Galactic Black Hole sources, keeping in mind the evolution of temporal and spectral features during the outburst. We present results of evolution of quasi-periodic oscillations, spectral states and possible connection with jet ejections during the outburst phase. Further, we attempt to connect the observedX-ray variabilities (i.e., 'class'/'structured' variabilities, similar to GRS 1915+105) with spectral states of black hole sources. Towards these studies, we consider three black hole sources that have undergone single (XTE J1859+226), a few (IGR J17091-3624) and many (GX 339-4) outbursts since the start of RXTE era. Finally, we model the broadband energy spectra (3-150 keV) of different spectral states using RXTE and NuSTAR observations. Results are discussed in the context of two-component advective flow model, while constraining the mass of the three black hole sources.
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| 9. |
- Straus, Laura D., et al.
(författare)
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The role of objective sleep in implicit and explicit affect regulation : A comprehensive review
- 2024
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Ingår i: Neurobiology of Stress. - : Elsevier. - 2352-2895. ; 31
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Forskningsöversikt (refereegranskat)abstract
- Impairments in sleep and affect regulation are evident across a wide range of mental disorders. Understanding the sleep factors that relate to affect regulatory difficulties will inform mechanistic understanding and aid in treatment. Despite rising interest, some research challenges in this area include integrating across different clinical and non-clinical literatures investigating the role of sleep architecture (measured with polysomnography) and experimentally manipulated sleep, as well as integrating more explicit versus implicit affect regulation processes. In this comprehensive review, we use a unifying framework to examine sleep's relationship with implicit-automatic regulation and explicit-controlled regulation, both of which are relevant to mental health (e.g., PTSD and depression). Many studies of implicit-automatic regulation (e.g., fear extinction and safety learning) demonstrate the importance of sleep, and REM sleep specifically. Studies of explicit-controlled regulation (e.g., cognitive reappraisal and expressive suppression) are less consistent in their findings, with results differing depending on the type of affect regulation and/or way that sleep was measured or manipulated. There is a clear relationship between objective sleep and affect regulation processes. However, there is a need for 1) more studies focusing on sleep and explicit-controlled affect regulation; 2) replication with the same types of regulation strategies; 3) more studies experimentally manipulating sleep to examine its impact on affect regulation and vice versa in order to infer cause and effect; and 4) more studies looking at sleep's impact on next-day affect regulation (not just overnight change in affect reactivity).
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