| 1. |
- Perez-Nadales, Elena, et al.
(författare)
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Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales : The impact of cytomegalovirus disease and lymphopenia
- 2020
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Ingår i: American Journal of Transplantation. - : WILEY. - 1600-6135 .- 1600-6143. ; 20:6, s. 1629-1641
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Tidskriftsartikel (refereegranskat)abstract
- Treatment of carbapenemase-producing Enterobacterales bloodstream infections in solid organ transplant recipients is challenging. The objective of this study was to develop a specific score to predict mortality in solid organ transplant recipients with carbapenemase-producing Enterobacterales bloodstream infections. A multinational, retrospective (2004-2016) cohort study (INCREMENT-SOT, ClinicalTrials.gov NCT02852902) was performed. The main outcome variable was 30-day all-cause mortality. The INCREMENT-SOT-CPE score was developed using logistic regression. The global cohort included 216 patients. The final logistic regression model included the following variables: INCREMENT-CPE mortality score >= 8 (8 points), no source control (3 points), inappropriate empirical therapy (2 points), cytomegalovirus disease (7 points), lymphopenia (4 points), and the interaction between INCREMENT-CPE score >= 8 and CMV disease (minus 7 points). This score showed an area under the receiver operating characteristic curve of 0.82 (95% confidence interval [CI] 0.76-0.88) and classified patients into 3 strata: 0-7 (low mortality), 8-11 (high mortality), and 12-17 (very-high mortality). We performed a stratified analysis of the effect of monotherapy vs combination therapy among 165 patients who received appropriate therapy. Monotherapy was associated with higher mortality only in the very-high (adjusted hazard ratio [HR] 2.82, 95% CI 1.13-7.06, P = .03) and high (HR 9.93, 95% CI 2.08-47.40, P = .004) mortality risk strata. A score-based algorithm is provided for therapy guidance.
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| 2. |
- Callegati, F., et al.
(författare)
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Research on Optical Core Networks in the e-Photon/ONe Network of Excellence
- 2006
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Ingår i: 25TH IEEE INTERNATIONAL CONFERENCE ON COMPUTER COMMUNICATIONS, VOLS 1-7, PROCEEDINGS IEEE INFOCOM 2006. ; , s. 2987-2991
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Konferensbidrag (refereegranskat)abstract
- This papers reports the advances in optical core networks research coordinated in the framework of the e- photon/ONe and e-photon/ONe+ networks of excellence.
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| 3. |
- Green, Jonathan M. H., et al.
(författare)
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Research priorities for managing the impacts and dependencies of business upon food, energy, water and the environment
- 2017
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Ingår i: Sustainability Science. - : Springer Science and Business Media LLC. - 1862-4065 .- 1862-4057. ; 12:2, s. 319-331
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Tidskriftsartikel (refereegranskat)abstract
- Delivering access to sufficient food, energy and water resources to ensure human wellbeing is a major concern for governments worldwide. However, it is crucial to account for the 'nexus' of interactions between these natural resources and the consequent implications for human wellbeing. The private sector has a critical role in driving positive change towards more sustainable nexus management and could reap considerable benefits from collaboration with researchers to devise solutions to some of the foremost sustainability challenges of today. Yet opportunities are missed because the private sector is rarely involved in the formulation of deliverable research priorities. We convened senior research scientists and influential business leaders to collaboratively identify the top forty questions that, if answered, would best help companies understand and manage their food-energy-water-environment nexus dependencies and impacts. Codification of the top order nexus themes highlighted research priorities around development of pragmatic yet credible tools that allow businesses to incorporate nexus interactions into their decision-making; demonstration of the business case for more sustainable nexus management; identification of the most effective levers for behaviour change; and understanding incentives or circumstances that allow individuals and businesses to take a leadership stance. Greater investment in the complex but productive relations between the private sector and research community will create deeper and more meaningful collaboration and cooperation.
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| 4. |
- Grossmann, Igor, et al.
(författare)
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Insights into the accuracy of social scientists' forecasts of societal change
- 2023
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Ingår i: Nature Human Behaviour. - : Springer Nature. - 2397-3374. ; 7, s. 484-501
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Tidskriftsartikel (refereegranskat)abstract
- How well can social scientists predict societal change, and what processes underlie their predictions? To answer these questions, we ran two forecasting tournaments testing the accuracy of predictions of societal change in domains commonly studied in the social sciences: ideological preferences, political polarization, life satisfaction, sentiment on social media, and gender-career and racial bias. After we provided them with historical trend data on the relevant domain, social scientists submitted pre-registered monthly forecasts for a year (Tournament 1; N = 86 teams and 359 forecasts), with an opportunity to update forecasts on the basis of new data six months later (Tournament 2; N = 120 teams and 546 forecasts). Benchmarking forecasting accuracy revealed that social scientists' forecasts were on average no more accurate than those of simple statistical models (historical means, random walks or linear regressions) or the aggregate forecasts of a sample from the general public (N = 802). However, scientists were more accurate if they had scientific expertise in a prediction domain, were interdisciplinary, used simpler models and based predictions on prior data. How accurate are social scientists in predicting societal change, and what processes underlie their predictions? Grossmann et al. report the findings of two forecasting tournaments. Social scientists' forecasts were on average no more accurate than those of simple statistical models.
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| 5. |
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| 6. |
- Carli, F, et al.
(författare)
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Exposure to Endocrine Disruptors (Di(2-Ethylhexyl)phthalate (DEHP) and Bisphenol A (BPA)) in Women from Different Residing Areas in Italy: Data from the LIFE PERSUADED Project
- 2022
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Ingår i: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 23:24
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Tidskriftsartikel (refereegranskat)abstract
- Phthalates and bisphenol A (BPA) are plasticizers used in many industrial products that can act as endocrine disruptors and lead to metabolic diseases. During the LIFE PERSUADED project, we measured the urinary concentrations of BPA and Di(2-ethylhexyl)phthalate (DEHP) metabolites in 900 Italian women representative of the Italian female adult population (living in the north, centre, and south of Italy in both rural and urban areas). The whole cohort was exposed to DEHP and BPA with measurable levels above limit of detection in more than 99% and 95% of the samples, respectively. The exposure patterns differed for the two chemicals in the three macro-areas with the highest urinary levels for DEHP in south compared to central and northern Italy and for BPA in northern compared to central and southern Italy. BPA levels were higher in women living in urban areas, whereas no difference between areas was observed for DEHP. The estimated daily intake of BPA was 0.11 μg/kg per day, about 36-fold below the current temporary tolerable daily intake of 4 μg/kg per day established by the EFSA in 2015. The analysis of cumulative exposure showed a positive correlation between DEHP and BPA. Further, the reduction of exposure to DEHP and BPA, through specific legislative measures, is necessary to limit the harmfulness of these substances.
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| 7. |
- Khorsandi, B. M., et al.
(författare)
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Survivable BBU hotel placement in a C-RAN with an optical WDM transport
- 2017
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Ingår i: DRCN 2017 - 13th International Conference on Design of Reliable Communication Networks. - : Institute of Electrical and Electronics Engineers (IEEE). - 9783800743834
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Konferensbidrag (refereegranskat)abstract
- In Centralized Radio Access Networks (C-RANs) Baseband Units (BBUs) are decoupled from Remote Radio Units (RRUs) and placed in BBU Hotels. In this way baseband processing resources can be shared among RRUs, providing opportunities for radio coordination and cost/energy savings. However, the failure of a BBU Hotel can affect a large number of RRUs creating severe outages in the radio network. For this reason, the design of a resilient C-RAN is extremely important. This paper focuses on the survivable BBU Hotel placement problem in C-RANs with an optical wavelength division multiplexing (WDM) transport. We first propose an algorithm that jointly decides (i) the placement of a minimum number of BBU Hotels and (ii) solves the Routing and Wavelength Assignment (RWA) problem for the fronthaul connections, ensuring that each RRU is connected to two different BBU Hotels (i.e., one primary and one backup). Then, we present a strategy for maximizing the sharing of backup BBU ports among RRUs, with the aim of reducing the total cost of the C-RAN while guaranteeing uninterrupted service provisioning in case of single BBU Hotel failure. Simulation results show that the proposed strategy helps reducing the overall C-RAN cost. On the other hand, it becomes also evident that the sharing benefits can be maximized only in the presence of a transport network with enough wavelength resources to handle potential bottlenecks that may occur when BBU Hotels are placed quite far from RRUs.
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| 8. |
- Licciardello, M., et al.
(författare)
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Performance evaluation of abstraction models for orchestration of distributed data center networks
- 2017
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Ingår i: 2017 19th International Conference on Transparent Optical Networks (ICTON). - : IEEE Computer Society. - 9781538608586
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Konferensbidrag (refereegranskat)abstract
- Cloud computing is increasingly based on geographically distributed data centers interconnected by high performance networks. Application of Software Defined Networking (SDN) is studied as an emerging solution to support dynamic network resource management for distributed data centers (DCs) jointly with extensive use of Network Function Virtualization (NFV). SDN/NFV operation takes advantage of orchestration of network control functions according to distributed DCs communication needs. Orchestration relies on a set of logical information related to the underlying infrastructure, called abstraction, which offers different levels of visibility of available resources, depending on the abstraction strategy adopted.
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| 9. |
- Raffaelli, C., et al.
(författare)
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Optimization of Centralized Radio access networks in indoor areas
- 2016
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Ingår i: International Conference on Transparent Optical Networks. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781509014675
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Konferensbidrag (refereegranskat)abstract
- A Centralized Radio Architecture (CRA) allows for the coordination of the physical layer functions of macro and small cells. Efficient techniques can be introduced based on the CRA concept, but deployment cost could potentially increase if CRA networks are not carefully designed. This paper proposes a number of design strategies aimed at cost minimization for CRA networks in residential areas based on heuristics which easily scale with the number of indoor antennas. A few different algorithms, which aim at reducing the overall amount of equipment to cover the area, are described and compared.
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| 10. |
- Raffaelli, C., et al.
(författare)
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Photonics in Switching in NoE e-Photon/One
- 2007
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Ingår i: ICTON 2007. ; , s. 167-170
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Konferensbidrag (refereegranskat)abstract
- The exploitation of photonic technology through application of switching principles and system concepts in switch implementation, i.e. photonics in switching, is a very challenging topic in the field of optical networking research. Many European research teams have been involved in high quality studies and trials in this field since several years and obtained funding opportunities for joining their expertise within the e-photon/One+ Network of Excellence. This talk aims at presenting how collaborations on photonics in switching research has been organized within e-Photon/One+ and which actions have been finalized for exploitation and dissemination of this knowledge in science and education. The paper will report a description of research contributions from different partners involved in photonics in switching research.
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