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Sökning: WFRF:(Ragnarsson GB)

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1.
  • Mikaelsdottir, E, et al. (författare)
  • Genetic variants associated with platelet count are predictive of human disease and physiological markers
  • 2021
  • Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 4:1, s. 1132-
  • Tidskriftsartikel (refereegranskat)abstract
    • Platelets play an important role in hemostasis and other aspects of vascular biology. We conducted a meta-analysis of platelet count GWAS using data on 536,974 Europeans and identified 577 independent associations. To search for mechanisms through which these variants affect platelets, we applied cis-expression quantitative trait locus, DEPICT and IPA analyses and assessed genetic sharing between platelet count and various traits using polygenic risk scoring. We found genetic sharing between platelet count and counts of other blood cells (except red blood cells), in addition to several other quantitative traits, including markers of cardiovascular, liver and kidney functions, height, and weight. Platelet count polygenic risk score was predictive of myeloproliferative neoplasms, rheumatoid arthritis, ankylosing spondylitis, hypertension, and benign prostate hyperplasia. Taken together, these results advance understanding of diverse aspects of platelet biology and how they affect biological processes in health and disease.
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2.
  • Neusser, A, et al. (författare)
  • Superdeformed band at very high spin in Nd-140
  • 2004
  • Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 70:6
  • Tidskriftsartikel (refereegranskat)abstract
    • A new high-spin superdeformed band has been discovered in Nd-140(60)80. It was populated in the Zr-96(Ca-48,4n) reaction and investigated using the EUROBALL gamma-ray spectrometer array. The band is observed in the approximate spin range of I=36 to 66. It is associated with shell gaps around Z=60 and at N=80 at large deformation. These gaps produce a pronounced minimum in the calculated total Routhian surfaces at a quadrupole deformation of epsilon(2)=0.45. The new band which lies between the high-deformation bands in the Aapproximate to130 region and the superdeformed bands in Aapproximate to150 nuclei provides insight into the development of the deformation between these two regions. Two possible configurations are suggested involving four neutrons of i(13/2) origin (nu6(4)) and either six protons of h(11/2)/h(9/2) origin (pi5(6)) or five protons of h(11/2)/h(9/2) and one of i(13/2) origin (pi5(5)6(1)).
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3.
  • Singh, AK, et al. (författare)
  • Evidence for noncollective oblate structures at high spin in Cs-123
  • 2004
  • Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 70:3
  • Tidskriftsartikel (refereegranskat)abstract
    • High-spin states in Cs-123 were populated in the Ni-64(Ni-64,p4n) reaction at a beam energy of 265 MeV. Gamma-ray coincidences were measured using the Gammasphere spectrometer. Two additional bands have been placed in the level scheme and the four previously known bands have been extended to higher spin. At the highest spins, two of the bands show irregular level sequences. These structures of noncollective excitations, which compete with collective rotation, are interpreted as band-terminating states. The results are compared to cranked Nilsson-Strutinsky calculations, and configuration assignments to the bands and to the terminating states are discussed.
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