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Sökning: WFRF:(Rajalingam Raja)

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1.
  • Abi-Rached, Laurent, et al. (författare)
  • The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans
  • 2011
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 334:6052, s. 89-94
  • Tidskriftsartikel (refereegranskat)abstract
    • Whole genome comparisons identified introgression from archaic to modern humans. Our analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system components subject to strong balancing selection, shows how modern humans acquired the HLA-B*73 allele in west Asia through admixture with archaic humans called Denisovans, a likely sister group to the Neandertals. Virtual genotyping of Denisovan and Neandertal genomes identified archaic HLA haplotypes carrying functionally distinctive alleles that have introgressed into modern Eurasian and Oceanian populations. These alleles, of which several encode unique or strong ligands for natural killer cell receptors, now represent more than half the HLA alleles of modern Eurasians and also appear to have been later introduced into Africans. Thus, adaptive introgression of archaic alleles has significantly shaped modern human immune systems.
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2.
  • Jhonsi, Mariadoss Asha, et al. (författare)
  • Investigation on the Photoinduced Interaction Between Water Soluble CdTe Quantum Dots and Certain Antioxidants
  • 2011
  • Ingår i: Advanced Science Letters. - : American Scientific Publishers. - 1936-6612. ; 4:11-12, s. 3490-3495
  • Tidskriftsartikel (refereegranskat)abstract
    • Photoinduced interaction of thioglycolic acid (TGA) capped CdTe quantum dots (QDs) with certain antioxidants such as estrogens and flavonoids has been investigated by using steady state and time resolved fluorescence spectroscopy. Reduction of electron-hole recombination has been observed (i.e., fluorescence quenching) while adding antioxidants to CdTe QDs. The Stern-Volmer constant (K-SV), quenching rate constant (k(q)) and binding constants (K) were obtained from fluorescence quenching data. The antioxidant interacts with QDs through static quenching, which was confirmed by unaltered fluorescence lifetime.
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