| 1. |
- Almesåker, Ann, et al.
(författare)
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Coordination chemistry of N,N,4-tris(pyridin-2-ylmethyl)aniline, a novel flexible, multimodal ligand
- 2007
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Ingår i: CrystEngComm. - : Royal Society of Chemistry (RSC). - 1466-8033. ; 9:11, s. 997-1010
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Tidskriftsartikel (refereegranskat)abstract
- The ligand N, N, 4-tris(pyridin-2-ylmethyl) aniline was synthethised using a multicomponent reaction, which is applicable to the synthesis of a large library of similarly structured ligands. A range of metal complexes with copper, cobalt and manganese ions were crystallised as discrete complexes, dimers and 1D coordination polymers, illustrating the flexibility of the ligand in the preparation of diverse structures. While coordination about the metal centres is similar in each group with a common metal ion, the different structures represent materials with varying structural and packing topologies. Varying the counterions and crystallisation solvents gives rise to discrete complexes, dimers and a porous 1D coordination polymer. In the latter case, solvent molecules entrapped in the channels are replaceable and guest exchange is detected by single crystal and powder diffraction indicating interesting storage possibilities.
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| 2. |
- Podmore, Clara, et al.
(författare)
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Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes : The EPIC-InterAct Study
- 2016
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Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 39:4, s. 572-581
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores in T2D development. However, ferritin is influenced by factors other than iron stores, which is less the case for other biomarkers of iron metabolism. We investigated associations of ferritin, transferrin saturation (TSAT), serum iron, and transferrin with T2D incidence to clarify the role of iron in the pathogenesis of T2D.RESEARCH DESIGN AND METHODS The European Prospective Investigation into Cancer and Nutrition-InterAct study includes 12,403 incident T2D cases and a representative subcohort of 16,154 individuals from a European cohort with 3.99 million person-years of follow-up. We studied the prospective association of ferritin, TSAT, serum iron, and transferrin with incident T2D in 11,052 cases and a random subcohort of 15,182 individuals and assessed whether these associations differed by subgroups of the population.RESULTS Higher levels of ferritin and transferrin were associated with a higher risk of T2D (hazard ratio [HR] [95% CI] in men and women, respectively: 1.07 [1.01-1.12] and 1.12 [1.05-1.19] per 100mg/L higher ferritin level; 1.11 [1.00-1.24] and 1.22 [1.12-1.33] per 0.5 g/L higher transferrin level) after adjustment for age, center, BMI, physical activity, smoking status, education, hs-CRP, alanine aminotransferase, and g-glutamyl transferase. Elevated TSAT (>= 45% vs. <45%) was associated with a lower risk of T2D in women (0.68 [0.54-0.86]) but was not statistically significantly associated in men (0.90 [0.75-1.08]). Serum iron was not associated with T2D. The association of ferritin with T2D was stronger among leaner individuals (P-interaction < 0.01).CONCLUSIONS The pattern of association of TSAT and transferrin with T2D suggests that the underlying relationship between iron stores and T2D is more complex than the simple link suggested by the association of ferritin with T2D.
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| 3. |
- Zacharias, Savannah C., et al.
(författare)
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Solvatochromism and the effect of solvent on properties in a two-dimensional coordination polymer of cobalt-trimesate
- 2022
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Ingår i: CRYSTENGCOMM. - : Royal Society of Chemistry (RSC). - 1466-8033. ; 24:13, s. 2393-2401
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Tidskriftsartikel (refereegranskat)abstract
- Stimuli responsive porous materials are being investigated for a plethora of potential applications. These materials have the ability to respond to their physical and chemical environment and thus provide an opportunity to study supramolecular type interactions. We present an investigation into the effects of guest inclusion on framework flexibility in a two-dimensional polymer network, {[Co(btc)(DMF)(2)]center dot xDMF}(n) (1) where btc is benzene-1,3,5-tricarboxylate (trimesate) and DMF N,N-dimethylformamide. Solvents for guest exchange were selected to explore different potential interactions, such as hydrogen bonding (water and alcohols) and it-stacking (benzonitrile) and to cover a wide range of polarities and molecular sizes. Results showed that all solvents used could be exchanged directly for the guest DMF with accompanying visible colour changes. The incorporation of the new guest solvent was confirmed by PXRD and thermal analysis. This process is reversible for most solvents. On removal of the guest DMF, the framework (1-f) is retained, but layers collapse to a less crystalline material. Only water and methanol are capable of penetrating the material to reconstitute the layers. The crystal structure of the guest-exchanged system with benzonitrile (2) showed that the coordination polymer framework is retained, albeit with a change in symmetry and interlayer spacing, making 1 an example of a 'breathing' coordination polymer. A survey of related structures in the CSD found that there are four common motifs, which cannot be predicted from either the composition or space group symmetry of the compound.
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