| 1. |
- Freitag, Daniel F., et al.
(författare)
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Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis
- 2015
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Ingår i: The Lancet Diabetes & Endocrinology. - 2213-8595. ; 3:4, s. 243-253
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Tidskriftsartikel (refereegranskat)abstract
- Background To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation. Methods We created a genetic score combining the effects of alleles of two common variants (rs6743376 and rs1542176) that are located upstream of IL1RN, the gene encoding the IL-1 receptor antagonist (IL-1Ra; an endogenous inhibitor of both IL-1 alpha and IL-1 beta); both alleles increase soluble IL-1Ra protein concentration. We compared effects on inflammation biomarkers of this genetic score with those of anakinra, the recombinant form of IL-1Ra, which has previously been studied in randomised trials of rheumatoid arthritis and other inflammatory disorders. In primary analyses, we investigated the score in relation to rheumatoid arthritis and four cardiometabolic diseases (type 2 diabetes, coronary heart disease, ischaemic stroke, and abdominal aortic aneurysm; 453 411 total participants). In exploratory analyses, we studied the relation of the score to many disease traits and to 24 other disorders of proposed relevance to IL-1 signalling (746 171 total participants). Findings For each IL1RN minor allele inherited, serum concentrations of IL-1Ra increased by 0.22 SD (95% CI 0.18-0.25; 12.5%; p=9.3 x 10(-33)), concentrations of interleukin 6 decreased by 0.02 SD (-0.04 to -0.01; -1,7%; p=3.5 x 10(-3)), and concentrations of C-reactive protein decreased by 0.03 SD (-0.04 to -0.02; -3.4%; p=7.7 x 10(-14)). We noted the effects of the genetic score on these inflammation biomarkers to be directionally concordant with those of anakinra. The allele count of the genetic score had roughly log-linear, dose-dependent associations with both IL-1Ra concentration and risk of coronary heart disease. For people who carried four IL-1Ra-raising alleles, the odds ratio for coronary heart disease was 1.15 (1.08-1.22; p=1.8 x 10(-6)) compared with people who carried no IL-1Ra-raising alleles; the per-allele odds ratio for coronary heart disease was 1.03 (1.02-1.04; p=3.9 x 10(-10)). Perallele odds ratios were 0.97 (0.95-0.99; p=9.9 x 10(-4)) for rheumatoid arthritis, 0.99 (0.97-1.01; p=0.47) for type 2 diabetes, 1.00 (0.98-1.02; p=0.92) for ischaemic stroke, and 1.08 (1.04-1.12; p=1.8 x 10(-5)) for abdominal aortic aneurysm. In exploratory analyses, we observed per-allele increases in concentrations of proatherogenic lipids, including LDL-cholesterol, but no clear evidence of association for blood pressure, glycaemic traits, or any of the 24 other disorders studied. Modelling suggested that the observed increase in LDL-cholesterol could account for about a third of the association observed between the genetic score and increased coronary risk. Interpretation Human genetic data suggest that long-term dual IL-1 alpha/beta inhibition could increase cardiovascular risk and, conversely, reduce the risk of development of rheumatoid arthritis. The cardiovascular risk might, in part, be mediated through an increase in proatherogenic lipid concentrations. Copyright (C) The Interleukin 1 Genetics Consortium. Open Access article distributed under the terms of CC-BY-NC-ND.
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| 2. |
- Ananth, S., et al.
(författare)
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Eleven-dimensional supergravity in light-cone superspace
- 2005
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Ingår i: Journal of High Energy Physics. - : Springer Science and Business Media LLC. - 1029-8479 .- 1126-6708. ; 5:5, s. 56-71
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Tidskriftsartikel (refereegranskat)abstract
- We show that Supergravity in eleven dimensions can be described in terms of a constrained superfield on the light-cone, without the use of auxiliary fields. We build its action to first order in the gravitational coupling constant \kappa, by "oxidizing" (N=8,d=4) Supergravity. This is simply achieved, as for N=4 Yang-Mills, by extending the transverse derivatives into superspace. The eleven-dimensional SuperPoincare algebra is constructed and a fourth order interaction is conjectured.
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| 3. |
- Belyaev, D., et al.
(författare)
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The BLG theory in light-cone superspace
- 2010
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Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; 2010:4
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Tidskriftsartikel (refereegranskat)abstract
- The light-cone superspace version of the d = 3, N = 8 superconformal theory of Bagger, Lambert and Gustavsson (BLG) is obtained as a solution to constraints imposed by OSp(2, 2 vertical bar 8) superalgebra. The Hamiltonian of the theory is shown to be a quadratic form of the dynamical supersymmetry transformation.
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| 4. |
- Brink, Lars, 1943, et al.
(författare)
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E7(7) on the Light Cone
- 2008
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Ingår i: Journal of High Energy Physics. - : Springer Science and Business Media LLC. - 1029-8479 .- 1126-6708. ; 2008:6
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Tidskriftsartikel (refereegranskat)abstract
- We use the Cremmer-Julia E-7(7) non-linear symmetry of N = 8 Supergravity to derive its order k(2) on-shell Hamiltonian in terms of one chiral light-cone superfield. By requiring that E-7(7) commute with the super-Poincare group, we deduce to lowest non-trivial order in k, the light cone E-7(7) transformations of all fields of the theory, including the gravition. We then derive the dynamical supersymmetry transformation to order k(2), and express the Hamiltonian as a quadratic form in the chiral superfield.
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| 5. |
- Brink, Lars, 1943, et al.
(författare)
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E8(8) in Light Cone Superspace
- 2008
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Ingår i: Journal of High Energy Physics. - : Springer Science and Business Media LLC. - 1029-8479 .- 1126-6708. ; 2008:7
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Tidskriftsartikel (refereegranskat)abstract
- We derive the non-linear action of E-8(8) on the constrained chiral superfield in the light-cone superspace with eight complex Grassmann variables. We construct (to lowest order in the coupling) the sixteen dynamical supersymmetries which generate a Hamiltonian with E-8(8) invariance in three space-time dimensions, and show that it has only interactions with even powers of the coupling constant.
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| 6. |
- Brink, Lars, 1943, et al.
(författare)
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Non-linear realization of PSU(2,2|4) on the light-cone
- 2005
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Ingår i: Nuclear Physics B. - : Elsevier BV. - 0550-3213. ; 722:1-2, s. 166-190
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Tidskriftsartikel (refereegranskat)abstract
- The symmetries of the N=4 SuperYang-Mills theory on the light-cone are discussed, solely in terms of its physical degrees of freedom. We derive explicit expressions for the generators of the PSU(2,2|4) superalgebra, both in the free theory, and to all orders in the gauge coupling of the classical theory. We use these symmetries to construct its Hamiltonian, and show that it can be written as a quadratic form of a fermionic superfield.
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| 7. |
- Rodriguez-Caballero, Alina, et al.
(författare)
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Treatment of high ethanol concentration wastewater by biological sand filters : Enhanced COD removal and bacterial community dynamics
- 2012
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Ingår i: Journal of Environmental Management. - : Elsevier BV. - 0301-4797 .- 1095-8630. ; 109, s. 54-60
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Tidskriftsartikel (refereegranskat)abstract
- Winery wastewater is characterized by its high chemical oxygen demand (COD), seasonal occurrence and variable composition, including periodic high ethanol concentrations. In addition, winery wastewater may contain insufficient inorganic nutrients for optimal biodegradation of organic constituents. Two pilot-scale biological sand filters (BSFs) were used to treat artificial wastewater: the first was amended with ethanol and the second with ethanol, inorganic nitrogen (N) and phosphorus (P). A number of biochemical parameters involved in the removal of pollutants through BSF systems were monitored, including effluent chemistry and bacterial community structures. The nutrient supplemented BSF showed efficient COD, N and P removal. Comparison of the COD removal efficiencies of the two BSFs showed that N and P addition enhanced COD removal efficiency by up to 16%. Molecular fingerprinting of BSF sediment samples using denaturing gradient gel electrophoresis (DGGE) showed that amendment with high concentrations of ethanol destabilized the microbial community structure, but that nutrient supplementation countered this effect.
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| 8. |
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