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| 2. |
- Dunham, I, et al.
(författare)
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The DNA sequence of human chromosome 22
- 1999
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 402:6761, s. 489-495
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Marinucci, A., et al.
(författare)
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Polarization constraints on the X-ray corona in Seyfert Galaxies : MCG-05-23-16
- 2022
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 516:4, s. 5907-5913
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Tidskriftsartikel (refereegranskat)abstract
- We report on the first observation of a radio-quiet active galactic nucleus (AGN) in polarized X-rays: the Seyfert 1.9 galaxy MCG-05-23-16. This source was pointed at with the Imaging X-ray Polarimetry Explorer (IXPE) starting on 2022 May 14 for a net observing time of 486 ks, simultaneously with XMM-Newton (58 ks) and NuSTAR (83 ks). A polarization degree Π smaller than 4.7 per cent (at the 99 per cent confidence level) is derived in the 2–8 keV energy range, where emission is dominated by the primary component ascribed to the hot corona. The broad-band spectrum, inferred from a simultaneous fit to the IXPE, NuSTAR, and XMM-Newton data, is well reproduced by a power law with photon index Γ = 1.85 ± 0.01 and a high-energy cutoff EC = 120 ± 15 keV. A comparison with Monte Carlo simulations shows that a lamp-post and a conical geometry of the corona are consistent with the observed upper limit, a slab geometry is allowed only if the inclination angle of the system is less than 50°.
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| 6. |
- Assani, K. D., et al.
(författare)
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The asymmetric bipolar [Fe II] jet and H 2 outflow of TMC1A resolved with the JWST NIRSpec Integral Field Unit
- 2024
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 688
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Tidskriftsartikel (refereegranskat)abstract
- Context. Protostellar outflows exhibit large variations in their structure depending on the observed gas emission. To understand the origin of the observed variations, it is important to analyze the differences in the observed morphology and kinematics of the different tracers. The James Webb Space Telescope (JWST) allows us to study the physical structure of the protostellar outflow through well-known near-infrared shock tracers in a manner unrivaled by other existing ground-based and space-based telescopes at these wavelengths. Aims. This study analyzes the atomic jet and molecular outflow in the Class I protostar, TMC1A, utilizing spatially resolved [Fe II] and H2 lines to characterize the morphology and to identify previously undetected spatial features, and compare them to existing observations of TMC1A and its outflows observed at other wavelengths. Methods. We identified a large number of [Fe II] and H2 lines within the G140H, G235H, and G395H gratings of the NIRSpec IFU observations. We analyzed their morphology and position-velocity (PV) diagrams. From the observed [Fe II] line ratios, the extinction toward the jet is estimated. Results. We detected the bipolar Fe jet by revealing, for the first time, the presence of a redshifted atomic jet. Similarly, the redshifted component of the H2 slower wide-angle outflow was observed. The [Fe II] and H2 redhifted emission both exhibit significantly lower flux densities compared to their blueshifted counterparts. Additionally, we report the detection of a collimated high-velocity (∼100 km s−1), blueshifted H2 outflow, suggesting the presence of a molecular jet in addition to the well-known wider angle low-velocity structure. The [Fe II] and H2 jets show multiple intensity peaks along the jet axis, which may be associated with ongoing or recent outburst events. In addition to the variation in their intensities, the H2 wide-angle outflow exhibits a ring-like structure. The blueshifted H2 outflow also shows a left-right brightness asymmetry likely due to interactions with the surrounding ambient medium and molecular outflows. Using the [Fe II] line ratios, the extinction along the atomic jet is estimated to be between AV = 10–30 on the blueshifted side, with a trend of decreasing extinction with distance from the protostar. A similar AV is found for the redshifted side, supporting the argument for an intrinsic red-blue outflow lobe asymmetry rather than environmental effects such as extinction. This intrinsic difference revealed by the unprecedented sensitivity of JWST, suggests that younger outflows already exhibit the red-blue side asymmetry more commonly observed toward jets associated with Class II disks.
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| 9. |
- Bernatsky, S, et al.
(författare)
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An International Cohort Study of Cancer in Systemic Lupus Erythematosus
- 2005
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Ingår i: Arthritis and Rheumatism. - : Wiley. - 1529-0131 .- 0004-3591. ; 52:5, s. 1481-1490
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Tidskriftsartikel (refereegranskat)abstract
- Objective. There is increasing evidence in support of an association between systemic lupus erythematosus (SLE) and malignancy, but in earlier studies the association could not be quantified precisely. The present study was undertaken to ascertain the incidence of cancer in SLE patients, compared with that in the general population. Methods. We assembled a multisite (23 centers) international cohort of patients diagnosed as having SLE. Patients at each center were linked to regional tumor registries to determine cancer occurrence. Standardized incidence ratios (SIRs) were calculated as the ratio of observed to expected cancers. Cancers expected were determined by multiplying person-years in the cohort by the geographically matched age, sex, and calendar year-specific cancer rates, and summing over all person-years. Results. The 9,547 patients from 23 centers were observed for a total of 76,948 patient-years, with an average followup of 8 years. Within the observation interval, 431 cancers occurred. The data confirmed an increased risk of cancer among patients with SLE. For all cancers combined, the SIR estimate was 1.15 (95% confidence interval [95% CI] 1.05-1.27), for all hematologic malignancies, it was 2.75 (95% CI 2.13-3.49), and for non-Hodgkin's lymphoma, it was 3.64 (95% CI 2.63-4.93). The data also suggested an increased risk of lung cancer (SIR 1.37; 95% CI 1.05-1.76), and hepatobiliary cancer (SIR 2.60; 95% CI 1.25, 4.78). Conclusion. These results support the notion of an association between SLE and cancer and more precisely define the risk of non-Hodgkin's lymphoma in SLE. It is not yet known whether this association is mediated by genetic factors or exogenous exposures.
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| 10. |
- Bernatsky, S., et al.
(författare)
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Mortality in systemic lupus erythematosus
- 2006
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Ingår i: Arthritis and Rheumatism. - : Wiley. - 1529-0131 .- 0004-3591. ; 54:8, s. 2550-2557
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Tidskriftsartikel (refereegranskat)abstract
- Objective. To examine mortality rates in the largest systemic lupus erythematosus (SLE) cohort ever assembled. Methods. Our sample was a multisite international SLE cohort (23 centers, 9,547 patients). Deaths were ascertained by vital statistics registry linkage. Standardized mortality ratio (SMR; ratio of deaths observed to deaths expected) estimates were calculated for-all deaths and by cause. The effects of sex, age, SLE duration, race, and calendar-year periods were determined. Results. The overall SMR was 2.4 (95% confidence interval 2.3-2.5). Particularly high mortality was seen for circulatory disease, infections, renal disease, non-Hodgkin's lymphoma, and lung cancer. The highest SMR estimates were seen in patient groups characterized by female sex, younger age, SLE duration < 1 year, or black/African American race. There was a dramatic decrease in total SMR estimates across calendar-year periods, which was demonstrable for specific causes including death due to infections and death due to renal disorders. However, the SMR due to circulatory diseases tended to increase slightly from the 1970s to the year 2001. Conclusion. Our data from a very large multicenter international cohort emphasize what has been demonstrated previously in smaller samples. These results highlight the increased mortality rate in SLE patients compared with the general population, and they suggest particular risk associated with female sex, younger age, shorter SLE duration, and black/African American race. The risk for certain types of deaths, primarily related to lupus activity (such as renal disease), has decreased over time, while the risk for deaths due to circulatory disease does not appear to have diminished.
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