| 1. |
- Carbon, C, et al.
(författare)
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Clinical and bacteriologic efficacy of telithromycin in patients with bacteremic community-acquired pneumonia.
- 2006
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Ingår i: Respiratory medicine. - : Elsevier BV. - 0954-6111. ; 100:4, s. 577-85
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Tidskriftsartikel (refereegranskat)abstract
- This retrospective analysis was performed to determine the clinical and bacteriologic efficacy of the ketolide antibacterial telithromycin in patients with community-acquired pneumonia (CAP) with pneumococcal bacteremia. Patients 13 years old with radiologically confirmed CAP and a positive blood culture for Streptococcus pneumoniae at screening were analyzed from eight multicenter Phase III/IV clinical trials. In four open-label, non-comparative studies, patients received telithromycin 800 mg once daily for 7-10 days. In four randomized, controlled, double-blind, comparative studies, patients received telithromycin 800 mg once daily for 5-10 days or a comparator antimicrobial (amoxicillin 1000 mg three times daily, clarithromycin 500 mg twice daily, or trovafloxacin 200 mg once daily) for 7-10 days. In total, 118 patients (telithromycin, 94/1061 [8.9%]; comparator, 24/244 [9.8%]) had documented pneumococcal bacteremia. Those who were treated with telithromycin achieved a clinical cure rate of 90.2% (74/82, per-protocol population); S. pneumoniae was eradicated in 77/82 (93.9%) bacteremic patients who received telithromycin and 15/19 (78.9%) comparator-treated patients. Clinical cure was also observed among telithromycin-treated bacteremic patients who were infected with penicillin- or erythromycin-resistant strains of S. pneumoniae (5/7 and 8/10, respectively). In conclusion, telithromycin achieves high clinical and bacteriologic cure rates in CAP patients with pneumococcal bacteremia.
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| 2. |
- Fredriksson, Anna M K, 1979, et al.
(författare)
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Environmental sustainability in international sourcing – towards an integrated framework
- 2009
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Ingår i: NOFOMA, Jönköping, Juni 2009.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Purpose of this paper: The purpose of this paper is to achieve an international sourcing framework considering environmental sustainability. Design/methodology/approach: The paper is based on a research synthesis from existing literature and arriving at a conceptual framework considering areas of international sourcing, environmental logistics and environmental purchasing. Findings: The conceptual framework integrates all the identified means to address environmental sustainability in a generic international framework across five stages (1) recognition of need (2) product identification (3) supplier evaluation (4) Negotiation & supply (5) performance measurement and monitoring. Research limitations/implications (if applicable): This paper is a conceptual paper and lacks empirical testing which needs to performed in future research through exploratory studies. Practical implications (if applicable): This framework will aid practitioners in taking environmental conscious decisions when making international sourcing decisions. What is original/value of paper: This paper addresses the little developed area of environmental sustainability in international sourcing
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