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- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 5. |
- Frangoudis, Constantinos, et al.
(författare)
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Experimental analysis of the CNx nano-damping material’s effect on the dynamic performance of a milling process
- 2013
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Ingår i: Proceedings of the International Conference on Advanced Manufacturing Engineering and Technologies. - Stockholm : KTH Royal Institute of Technology. - 9789175018928 ; , s. 293-302
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Konferensbidrag (refereegranskat)abstract
- Vibration phenomena are a main consideration during the material removal operation, as it has prominent effects on the product quality, cutting tool life, and productivity of that machining operation. Within the context of machining performance, role of enhanced stiffness and damping on the dynamic behaviour of machining systems such as turning and milling is well established. In this experimental analysis, investigations have been conducted for identifying the natural characteristics and dynamic responses of a milling process with the application of a novel carbon based (CNx) nano-composite damping material. TheCNx material has been applied into the joint interface of a workholding device with adaptive dynamic stiffness. Prior investigations of this material, produced by theplasma enhanced chemical vapor (PECVD) process, showed inherent damping capacity via interfacial frictional losses of its micro-columnar structures. For thisstudy, natural characteristics of the workholding system have been characterized bythe modal impact testing method. Dynamic responses during the machining processhave been measured through the vibration acceleration signals. The ultimate objective of this study is to comprehend the potentiality of CNx coating material forimproving machining process performance by analyzing the frequency response functions and measured vibration signals of the investigated milling process with varying stiffness and damping levels.
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| 6. |
- Hussain, Sajid, et al.
(författare)
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Families of Extended Exponentiated Generalized Distributions and Applications of Medical Data Using Burr III Extended Exponentiated Weibull Distribution
- 2023
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Ingår i: Mathematics. - 2227-7390. ; 11:14
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Tidskriftsartikel (refereegranskat)abstract
- In this article, four new families named as Weibull extended exponentiated-X (WEE-X), Lomax extended exponentiated-X (LEE-X), Logistic extended exponentiated-X (LGCEE-X), and Burr III extended exponentiated-X (BIIIEE-X) with their quantile functions are proposed. The expressions for distribution function and density function of BIIIEE-X family are written in terms of linear combinations of the exponentiated densities based to parent model. New models, i.e., Weibul extended exponentiated Weibull (WEEW), Lomax extended exponentiated Weibull (LEEW), Logistic extended exponentiated Weibull (LGCEEW), and Burr III extended exponentiated-Weibull (BIIIEEW) distributions are derived, were plotted for functions of probability density and hazard rate at different levels of parameters. Some mathematical properties of the BIIIEEW model are disclosed. The maximum likelihood method for the BIIIEEW model are described. Numerical applications of the BIIIEEW model to disease of cancer datasets are provided.
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| 7. |
- Hussain, Sajid, et al.
(författare)
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The Exponentiated Power Alpha Index Generalized Family of Distributions : Properties and Applications
- 2023
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Ingår i: Mathematics. - : MDPI AG. - 2227-7390. ; 11:4, s. 900-900
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Tidskriftsartikel (refereegranskat)abstract
- The study of hydrological characteristics has a vital role in designing, planning, and managing water resources. The selection of appropriate probability distributions and methods of estimations are basic elements in hydrology analyses. In this article, a new family named the ‘exponentiated power alpha index generalized’ (EPAIG)-G is proposed to develop several new distributions. Using this proposed family, we developed a new model, called the EPAIG-exponential (EPAIG-E). A few structural properties of the EPAIG-G were obtained. The EPAIG-E parameters were estimated through the method of maximum likelihood (MML). The study of the Monte Carlo simulation (MCS) was produced for the EPAIG-E. The model performance is illustrated using real data.
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| 8. |
- Hussain, Sajid, et al.
(författare)
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The Generalized Alpha Exponent Power Family of Distributions : Properties and Applications
- 2022
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Ingår i: Mathematics. - : MDPI AG. - 2227-7390. ; 10:9
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Tidskriftsartikel (refereegranskat)abstract
- Here, a new method is recommended to characterize a new continuous distribution class, named the generalized alpha exponent power family of distributions (GAEPFDs). A particular sub-model is presented for exemplifying the objective. The basic statistical properties, such as ordinary moments, the probability weighted moments, mode, quantile, order statistics, entropy measures, and moment generating functions, etc., were explored. To gauge the GAEPPRD parameters, the ML technique was utilized. The estimator behaviour was studied by a Monte Carlo simulation study (MCSS). The effectiveness of GAEPFDs was demonstrated observationally through lifetime data. The applications show that GAEPFDs can offer preferable results over other competitive models.
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- Hussain, Sajid, et al.
(författare)
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The Generalized Exponential Extended Exponentiated Family of Distributions : Theory, Properties, and Applications
- 2022
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Ingår i: Mathematics. - : MDPI AG. - 2227-7390. ; 10:19
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Tidskriftsartikel (refereegranskat)abstract
- Here, we propose a new generalized exponential extended exponentiated (NGE3) family of distributions. Some statistical properties of proposed family are gained. The most extreme probability method, maximum likelihood (ML), is utilized for parameter estimation. We explore an exceptional model called NGE3-Exponential (NGE3E). NGE3E is estimated with ML, and the performance of estimators is demonstrated by utilizing a simulation. Moreover, two applications are given to show the significance and adaptability of the proposed model in comparison to some generalized models (GMs).
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- Kassimu, Kamaka, et al.
(författare)
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Safety and Tolerability of an Antimalarial Herbal Remedy in Healthy Volunteers : An Open-Label, Single-Arm, Dose-Escalation Study on Maytenus senegalensis in Tanzania
- 2022
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Ingår i: Tropical Medicine and Infectious Disease. - : MDPI. - 2414-6366. ; 7:12
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Tidskriftsartikel (refereegranskat)abstract
- Background: Though Maytenus senegalensis is one of the medicinal plants widely used in traditional medicine to treat infectious and inflammatory diseases in Africa, there is a lack of safety data regarding its use. Therefore, the study aimed to asselss the safety and tolerability of the antimalarial herbal remedy M. senegalensis. Material and Methods: The study design was an open-label, single-arm, dose-escalation. Twelve eligible male healthy Tanzanians aged 18 to 45 years were enrolled in four study dose groups. Volunteers' safety and tolerability post-investigational-product administration were monitored on days 0 to 7,14, and 56. Results: There were no deaths or serious adverse events in any of the study groups, nor any adverse events that resulted in premature discontinuation. The significant mean changes observed in WBC (p = 0.003), Neutrophils (p = 0.02), Lymphocytes (p = 0.001), Eosinophils (p = 0.009), Alanine aminotransferase (p = 0.002), Creatinine (p = 0.03) and Total bilirubin (p = 0.004) laboratory parameters were not associated with any signs of toxicity or clinical symptoms. Conclusions: M. senegalensis was demonstrated to be safe and tolerable when administered at a dose of 800 mg every eight hours a day for four days. This study design may be adapted to evaluate other herbal remedies.
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