| 1. |
- Cooper, Ian R., et al.
(författare)
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Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors
- 2016
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Ingår i: Bioorganic & Medicinal Chemistry Letters. - : Elsevier BV. - 0960-894X .- 1464-3405. ; 26:17, s. 4179-4183
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Tidskriftsartikel (refereegranskat)abstract
- There is an urgent and unmet medical need for new antibacterial drugs that tackle infections caused by multidrug-resistant (MDR) pathogens. During the course of our wider efforts to discover and exploit novel mechanism of action antibacterials, we have identified a novel series of isothiazolone based inhibitors of bacterial type II topoisomerase. Compounds from the class displayed excellent activity against both Gram-positive and Gram-negative bacteria with encouraging activity against a panel of MDR clinical Escherichia coli isolates when compared to ciprofloxacin. Representative compounds also displayed a promising in vitro safety profile.
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| 2. |
- Patterson, Allison, et al.
(författare)
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Foraging range scales with colony size in high-latitude seabirds
- 2022
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Ingår i: Current Biology. - : Elsevier BV. - 0960-9822 .- 1879-0445. ; 32:17, s. 3800-3807
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Tidskriftsartikel (refereegranskat)abstract
- Density-dependent prey depletion around breeding colonies has long been considered an important factor controlling the population dynamics of colonial animals.1, 2, 3, 4 Ashmole proposed that as seabird colony size increases, intraspecific competition leads to declines in reproductive success, as breeding adults must spend more time and energy to find prey farther from the colony.1 Seabird colony size often varies over several orders of magnitude within the same species and can include millions of individuals per colony.5,6 As such, colony size likely plays an important role in determining the individual behavior of its members and how the colony interacts with the surrounding environment.6 Using tracking data from murres (Uria spp.), the world’s most densely breeding seabirds, we show that the distribution of foraging-trip distances scales to colony size0.33 during the chick-rearing stage, consistent with Ashmole’s halo theory.1,2 This pattern occurred across colonies varying in size over three orders of magnitude and distributed throughout the North Atlantic region. The strong relationship between colony size and foraging range means that the foraging areas of some colonial species can be estimated from colony sizes, which is more practical to measure over a large geographic scale. Two-thirds of the North Atlantic murre population breed at the 16 largest colonies; by extrapolating the predicted foraging ranges to sites without tracking data, we show that only two of these large colonies have significant coverage as marine protected areas. Our results are an important example of how theoretical models, in this case, Ashmole’s version of central-place-foraging theory, can be applied to inform conservation and management in colonial breeding species.
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| 3. |
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| 4. |
- Boustedt, Jonas, et al.
(författare)
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Threshold concepts in computer science : do they exist and are they useful?
- 2007
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Ingår i: SIGCSE Bulletin inroads. - : Association for Computing Machinery (ACM). - 0097-8418. ; 39:1, s. 504-508
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Yes, and Yes.We are currently undertaking an empirical investigation of “Threshold Concepts” in Computer Science, with input from both instructors and students. We have found good empirical evidence that at least two concepts—Object-oriented programming and pointers—are Threshold Concepts, and that there are potentially many more others.In this paper, we present results gathered using various experimental techniques, and discuss how Threshold Concepts can affect the learning process.
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| 5. |
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| 6. |
- Eckerdal, Anna, et al.
(författare)
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Can graduating students design software systems?
- 2006
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Ingår i: SIGCSE ’06. - New York NY, USA : ACM. - 1595932593 ; , s. 403-407
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Konferensbidrag (refereegranskat)abstract
- This paper examines software designs produced by students nearing completion of their Computer Science degrees. The results of this multi-national, multi-institutional experiment present some interesting implications for educators.
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| 7. |
- Eckerdal, Anna, et al.
(författare)
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Can Graduating Students Design Software Systems?
- 2006
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Ingår i: SIGCSE Bulletin inroads. - : Association for Computing Machinery (ACM). - 0097-8418. ; 38:1, s. 403-407
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Tidskriftsartikel (refereegranskat)abstract
- This paper examines software designs produced by students nearing completion of their Computer Science degrees. The results of this multi-national, multi institutional experiment present some interesting implications for educators.
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| 8. |
- Eckerdal, Anna, et al.
(författare)
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Categorizing student software designs : methods, results, and implications
- 2006
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Ingår i: Computer Science Education. - : Informa UK Limited. - 0899-3408 .- 1744-5175. ; 16:3, s. 197-209
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Tidskriftsartikel (refereegranskat)abstract
- This paper examines the problem of studying and comparing student software designs. We propose semantic categorization as a way to organize widely varying data items. We describe how this was used to organize a particular multi-national, multi-institutional dataset, and present the results of this analysis: most students are unable to effectively design software. We examine how these designs vary with different academic and demographic factors, and discuss the implications of this work on both education and education research.
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| 9. |
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| 10. |
- Eckerdal, Anna, et al.
(författare)
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Putting Threshold Concepts into Context in Computer Science Education
- 2006
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Ingår i: SIGCSE Bulletin inroads. - : Association for Computing Machinery (ACM). - 0097-8418. ; 38:3, s. 103-107
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes Threshold Concepts, a theory of learning that distinguishes core concepts whose characteristics can make them troublesome in learning. With an eye to applying this theory in computer science, we consider this notion in the context of related topics in computer science education.
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