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- Abdullha, Khalid A., et al.
(författare)
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Mechanical properties, thermal and chemical effect of polymer cotton bars reinforced with carbon / glass fiber
- 2024
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Ingår i: Australian Journal of Mechanical Engineering. - : Taylor & Francis. - 1448-4846 .- 2204-2253. ; 22:3, s. 592-602
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Tidskriftsartikel (refereegranskat)abstract
- Many researchers are interested in using natural fibres to treat due to recent advancements in polymer characteristics. The mechanical properties of three types of bars are studied in this paper: Cotton Fibre-Reinforced Polymer bars, Cotton/Carbon Fibre-Reinforced Polymer bars, and Cotton/Glass Fibre-Reinforced Polymer bars. The goal of the paper was to create low-cost bars with comparable mechanical performance and corrosion resistance to steel reinforcement. The bars were made using two methods: fibres immersed in polymer and fibres coated with polymer by repeated tension and relaxation of fibres. The second method produced better results in terms of the tensile strength of Cot.CFRP, Cot.GFRP, and Cot.FRP bars, which were 688, 477, and 284 MPa, respectively, and the stress–strain curve revealed brittle behaviour for all bars and modulus of elasticity of 43, 31 and 22 GPa. When sand was put on the bar’s surface, the bars demonstrated a good connection with the concrete. It also showed good resistance to moisture, alkaline solutions and acids, as well as heat resistance at temperatures below 200°C.
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| 2. |
- Masood, KI, et al.
(författare)
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Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome
- 2021
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1, s. 22958-
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Tidskriftsartikel (refereegranskat)abstract
- Understanding key host protective mechanisms against SARS-CoV-2 infection can help improve treatment modalities for COVID-19. We used a blood transcriptome approach to study biomarkers associated with differing severity of COVID-19, comparing severe and mild Symptomatic disease with Asymptomatic COVID-19 and uninfected Controls. There was suppression of antigen presentation but upregulation of inflammatory and viral mRNA translation associated pathways in Symptomatic as compared with Asymptomatic cases. In severe COVID-19, CD177 a neutrophil marker, was upregulated while interferon stimulated genes (ISGs) were downregulated. Asymptomatic COVID-19 cases displayed upregulation of ISGs and humoral response genes with downregulation of ICAM3 and TLR8. Compared across the COVID-19 disease spectrum, we found type I interferon (IFN) responses to be significantly upregulated (IFNAR2, IRF2BP1, IRF4, MAVS, SAMHD1, TRIM1), or downregulated (SOCS3, IRF2BP2, IRF2BPL) in Asymptomatic as compared with mild and severe COVID-19, with the dysregulation of an increasing number of ISGs associated with progressive disease. These data suggest that initial early responses against SARS-CoV-2 may be effectively controlled by ISGs. Therefore, we hypothesize that treatment with type I interferons in the early stage of COVID-19 may limit disease progression by limiting SARS-CoV-2 in the host.
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| 3. |
- Razzak, S. B. A., et al.
(författare)
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Quantitative and qualitative assessments of microbial contamination in some bottled and tap water with their drug resistant pattern
- 2021
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Ingår i: International Food Research Journal. - 1985-4668. ; 28:5, s. 945-952
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Tidskriftsartikel (refereegranskat)abstract
- The present work focussed on the concerns of the existence of coliform, faecal coliform, and other pathogens in both tap water and commercially available bottled water, along with the drug resistant pattern of the isolates. The physico-chemical features of the bottled water samples were satisfactory, but most of the tap water exceeded the marginal limit. A total of 21 samples (10 of tap water and 11 of bottled water) were collected and processed for microbiological analysis. All the samples were found to be contaminated with total viable bacteria up to 10(8) CFU/mL. Among the 21 samples, seven samples were found to be contaminated with E. coli up to 10(6) CFU/mL, and six samples had Klebsiella spp. up to 10(2) CFU/mL. Faecal contamination was totally absent in all bottled water, but present in four tap water samples. Fungi was found in six samples within the range of 10(2) to 10(3) CFU/mL. Surprisingly, Staphylococcus spp. were observed in all bottled water. Vibrio spp. were detected in three samples. An elevated number of faecal coliforms, Klebsiella spp., Salmonella spp., Shigella spp., Vibrio spp., and Pseudomonas spp. were estimated among the tap water samples up to 10(5) CFU/mL. The water samples, especially tap water, collected from the different areas were microbiologically unsafe, as few pathogenic microorganisms were found in several samples. This indicated as public health threat. Most of the isolates from both tap and bottled water samples were found to be resistant against more than one antibiotic tested, which is extremely alarming for the consumers. Very few antibiotics were found to be effective against the bacterial isolates. (C) All Rights Reserved.
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| 6. |
- Tamborero, D, et al.
(författare)
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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology
- 2022
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Ingår i: Nature cancer. - : Springer Science and Business Media LLC. - 2662-1347. ; 3:2, s. 251-
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Tidskriftsartikel (refereegranskat)abstract
- There is a growing need for systems that efficiently support the work of medical teams at the precision-oncology point of care. Here, we present the implementation of the Molecular Tumor Board Portal (MTBP), an academic clinical decision support system developed under the umbrella of Cancer Core Europe that creates a unified legal, scientific and technological platform to share and harness next-generation sequencing data. Automating the interpretation and reporting of sequencing results decrease the need for time-consuming manual procedures that are prone to errors. The adoption of an expert-agreed process to systematically link tumor molecular profiles with clinical actions promotes consistent decision-making and structured data capture across the connected centers. The use of information-rich patient reports with interactive content facilitates collaborative discussion of complex cases during virtual molecular tumor board meetings. Overall, streamlined digital systems like the MTBP are crucial to better address the challenges brought by precision oncology and accelerate the use of emerging biomarkers.
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| 10. |
- Razzak, Junaid A
(författare)
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The potential of ambulance records for a road traffic safety agenda in low-income cities : studies from Karachi, Pakistan
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Road traffic injuries (RTIs) are a major public health problem in low-income countries. The overall aim of the thesis is to increase knowledge about the characteristics of RTI events and victims and their changes over time in an urban, low-income setting. The accuracy of ambulance data for RTI surveillance is also investigated. All studies forming the thesis are register-based and were conducted in Karachi (Pakistan). Data collections took place both in 1996-1997 (reference period 1993-95) and in 2003-2004 (reference period 2003). Common to all studies is the use of Edhi Ambulance Service (EAS) logbooks. In study 1, the epidemiology of childhood RTIs was analysed. Study 2 assessed the magnitude of RTIs for all age groups. EAS logbook data were matched with traffic' police OBS data so as to compile incidence estimates of RTI mortality and morbidity using a two-sample capture-recapture design. Study 3 dealt with the accuracy (validity and quality) of EAS data. A comparison was made of the data points of individual patients with hospital and medico-legal department data. In Study 4 , injury data from ambulance records were compared for two one-year periods (1995 and 2003); significance of differences between years were measured using proportions of injuries. For the period 1993-95, children aged 0-15 incurred 21% of the total number of RTIs recorded. 15% of the fatally injured children died either at the scene of the accident or during transportation to the hospital. Buses, minibuses and trucks were involved in 54% of all cases. For the year 1994, police reported 544 deaths and 793 injuries while ambulance records noted 343 deaths and 2048 injuries due to road traffic crashes. It was estimated that at least 972 (CI=912, 1031) deaths and 18936 (CI=15507, 22342) injuries occurred during the study period. Traffic police records recorded only 56% of deaths and 4 % of serious injuries, while the ambulance data counted only 35% of deaths and 11% of serious injuries. About ten years later, a total of 1,245 adult RTI victims were transported by the EAS during 2003, most of which were males (89.6%). Comparing 1995 and 2003 showed a 41% lower number of RTIs in 2003 compared to 1995, with a 35% increase in the prehos ital mortality. The road users most likely to be injured remained similar. There were missing entries in EAS records in about one in four cases (27%), the majority of which were the unique identifiers like name and age (67%). Data on other variables were reported in 95% or more cases. The agreement rate for the variables available in the three datasets ranged from 61% to 100%. In sum, the burden of RTIs in Karachi is much larger than would be expected if only ambulance or police data alone were used to generate incidence rates. While many victims and events characteristics remain unchanged between the two periods, an augmentation in case mortality rates occurs. Further, while there are limitations to all three major sources of road traffic injury information in the city, ambulance records provide as accurate and more detailed information than either the medico legal reports or the hospital records.
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