| 1. |
- Haller, Stephanie, et al.
(författare)
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Folate receptor-targeted radionuclide therapy: preclinical investigation of anti-tumor effects and potential radionephropathy.
- 2015
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Ingår i: Nuclear medicine and biology. - : Elsevier BV. - 1872-9614 .- 0969-8051. ; 42:10, s. 770-9
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Tidskriftsartikel (refereegranskat)abstract
- Application of therapeutic folate radioconjugates is a promising option for the treatment of folate receptor (FR)-positive tumors, although high uptake of radiofolates in the kidneys remains a critical issue. Recently, it was shown that enhancing the blood circulation of radiofolates results in increased tumor uptake and reduced retention of radioactivity in the kidneys. In this study, we investigated and compared the anti-tumor effects and potential long-term damage to the kidneys after application of an albumin-binding ((177)Lu-cm09), and a conventional ((177)Lu-EC0800) folate radioconjugate.
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| 2. |
- Haugen, Josefine, et al.
(författare)
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First insights into infants' and children's aha-experiences : A parent report study
- 2024
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Ingår i: Cognitive development. - 0885-2014 .- 1879-226X. ; 69
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Tidskriftsartikel (refereegranskat)abstract
- This study provides first insights into aha-experiences in infancy and childhood. In two studies, a content analysis of parental reports from two different populations, a Norwegian sample and an international sample of English-speaking parents, was conducted. Parents described 606 aha-stories of their children (age 3 weeks to 16 years). Three main findings were replicated across two studies: (1) Even infants may have aha-experiences; (2) Children have aha-experiences on various topics related to action and cognition; (3) The focus of aha-experiences shifts from action to cognition with age (3 weeks-8 years, Odds Ratios > 1.567). These findings may have implications for understanding what motivates children's learning and cognitive development and for future research.
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| 3. |
- Müller, Cristina, et al.
(författare)
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Direct in vitro and in vivo comparison of (161)Tb and (177)Lu using a tumour-targeting folate conjugate.
- 2014
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Ingår i: European journal of nuclear medicine and molecular imaging. - : Springer Science and Business Media LLC. - 1619-7089 .- 1619-7070. ; 41:3, s. 476-485
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Tidskriftsartikel (refereegranskat)abstract
- The radiolanthanide (161)Tb (T 1/2=6.90days, Eβ(-) av=154keV) was recently proposed as a potential alternative to (177)Lu (T 1/2=6.71days, Eβ(-) av=134keV) due to similar physical decay characteristics but additional conversion and Auger electrons that may enhance the therapeutic efficacy. The goal of this study was to compare (161)Tb and (177)Lu in vitro and in vivo using a tumour-targeted DOTA-folate conjugate (cm09).
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