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| 2. |
- Hansson, Petra, et al.
(författare)
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Coherence among phrases
- 2003
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Ingår i: [Host publication title missing]. ; , s. 607-610
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Konferensbidrag (refereegranskat)
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| 3. |
- Krauss, Tobias, et al.
(författare)
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Preventive medicine of von Hippel-Lindau disease-associated pancreatic neuroendocrine tumors
- 2018
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Ingår i: Endocrine-Related Cancer. - : BIOSCIENTIFICA LTD. - 1351-0088 .- 1479-6821. ; 25:9, s. 783-793
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Tidskriftsartikel (refereegranskat)abstract
- Pancreatic neuroendocrine tumors (PanNETs) are rare in von Hippel-Lindau disease (VHL) but cause serious morbidity and mortality. Management guidelines for VHL-PanNETs continue to be based on limited evidence, and survival data to guide surgical management are lacking. We established the European-American-Asian-VHL-PanNET-Registry to assess data for risks for metastases, survival and long-term outcomes to provide best management recommendations. Of 2330 VHL patients, 273 had a total of 484 PanNETs. Median age at diagnosis of PanNET was 35 years (range 10-75). Fifty-five (20%) patients had metastatic PanNETs. Metastatic PanNETs were significantly larger (median size 5 vs 2 cm; P < 0.001) and tumor volume doubling time (TVDT) was faster (22 vs 126 months; P = 0.001). All metastatic tumors were >= 2.8 cm. Codons 161 and 167 were hotspots for VHL germline mutations with enhanced risk for metastatic PanNETs. Multivariate prediction modeling disclosed maximum tumor diameter and TVDT as significant predictors for metastatic disease (positive and negative predictive values of 51% and 100% for diameter cut-off >= 2.8 cm, 44% and 91% for TVDT cut-off of <= 24 months). In 117 of 273 patients, PanNETs > 1.5 cm in diameter were operated. Ten-year survival was significantly longer in operated vs non-operated patients, in particular for PanNETs < 2.8 cm vs >= 2.8 cm (94% vs 85% by 10 years; P = 0.020; 80% vs 50% at 10 years; P = 0.030). This study demonstrates that patients with PanNET approaching the cut-off diameter of 2.8 cm should be operated. Mutations in exon 3, especially of codons 161/167 are at enhanced risk for metastatic PanNETs. Survival is significantly longer in operated non-metastatic VHL-PanNETs.
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| 4. |
- Wood, Sidney A J, et al.
(författare)
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Assimilation or coarticulation? Evidence from the coordination of tongue gestures for the palatalization of Bulgarian alveolar stops.
- 1996
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Ingår i: Journal of Phonetics. - : Elsevier BV. - 0095-4470. ; 24:1, s. 139-164
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Konferensbidrag (refereegranskat)abstract
- Three issues are considered in this report —are assimilation and coarticulation the same process or different, are they achieved by feature spreading or by coproduction, and what level or levels of neuromotor planning or production do they represent? Tongue gestures analysed from an X-ray motion film of Bulgarian speech are presented as examples of what the tongue is made to do in speech and of how those gestures are co-ordinated with other articulator gestures, in particular for the palatalization of apico-alveolar stops. The gestures involved in this assimilation are initiated earlier, or are held longer, than in nonassimilated situations. The revision of gesture timing in relation to adjacent activity indicates that assimilation is preplanned and does not reflect coarticulation or the effect of vocal tract biodynamics. Secondly, the gestural programming for this case of palatalization is better described as coproduction than feature spreading. Finally the temporal organization of coarticulation reported here also agrees with that reported previously. In particular, potentially conflicting gestures are not blended but are produced sequentially, which favors the gesture queuing paradigm rather than the tug-of-war paradigm and indicates that coarticulation is also preplanned.
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