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- Alkner, Sara, et al.
(författare)
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Quality assessment of radiotherapy in the prospective randomized SENOMAC trial
- 2024
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Ingår i: Radiotherapy and Oncology. - 0167-8140 .- 1879-0887. ; 197
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Tidskriftsartikel (refereegranskat)abstract
- Background and purpose: Recommendations for regional radiotherapy (RT) of sentinel lymph node (SLN)-positive breast cancer are debated. We here report a RT quality assessment of the SENOMAC trial.Materials and Methods: The SENOMAC trial randomized clinically node-negative breast cancer patients with 1–2 SLN macrometastases to completion axillary lymph node dissection (cALND) or SLN biopsy only between 2015–2021. Adjuvant RT followed national guidelines. RT plans for patients included in Sweden and Denmark until June 2019 were collected (N = 1176) and compared to case report forms (CRF). Dose to level I (N = 270) and the humeral head (N = 321) was analyzed in detail.Results: CRF-data and RT plans agreed in 99.3 % (breast/chest wall) and in 96.6 % of patients (regional RT). Congruence for whether level I was an intended RT target was lower (78 %). In accordance with Danish national guidelines, level I was more often an intended target in the SLN biopsy only arm (N = 334/611, 55 %,) than in the cALND arm (N = 174/565, 31 %,). When an intended target, level I received prescribed dose to 100 % (IQR 98–100 %) of the volume. However, even when not an intended target, full dose was delivered to > 80 % of level I (IQR 75–90 %). The intentional inclusion of level I in the target volume more than doubled the dose received by ≥ 50 % of the humeral head.Conclusion: Congruence between CRF data and RT plans was excellent. Level I received a high dose coverage even when not intentionally included in the target. Including level I in target significantly increased dose to the humeral head.
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| 3. |
- Alkner, Sara, et al.
(författare)
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Quality assessment of radiotherapy in the prospective randomized SENOMAC trial
- 2024
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Ingår i: Radiotherapy and Oncology. - : Elsevier. - 0167-8140 .- 1879-0887. ; 197
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Tidskriftsartikel (refereegranskat)abstract
- Background and purpose: Recommendations for regional radiotherapy (RT) of sentinel lymph node (SLN)-positive breast cancer are debated. We here report a RT quality assessment of the SENOMAC trial. Materials and Methods: The SENOMAC trial randomized clinically node-negative breast cancer patients with 1-2 SLN macrometastases to completion axillary lymph node dissection (cALND) or SLN biopsy only between 2015-2021. Adjuvant RT followed national guidelines. RT plans for patients included in Sweden and Denmark until June 2019 were collected (N = 1176) and compared to case report forms (CRF). Dose to level I (N = 270) and the humeral head (N = 321) was analyzed in detail.
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| 4. |
- de Boniface, J., et al.
(författare)
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The generalisability of randomised clinical trials: an interim external validity analysis of the ongoing SENOMAC trial in sentinel lymph node-positive breast cancer
- 2020
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Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 0167-6806 .- 1573-7217. ; 180:1, s. 167-176
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Tidskriftsartikel (refereegranskat)abstract
- Purpose None of the key randomised trials on the omission of axillary lymph node dissection (ALND) in sentinel lymph-positive breast cancer have reported external validity, even though results indicate selection bias. Our aim was to assess the external validity of the ongoing randomised SENOMAC trial by comparing characteristics of Swedish SENOMAC trial participants with non-included eligible patients registered in the Swedish National Breast Cancer Register (NKBC). Methods In the ongoing non-inferiority European SENOMAC trial, clinically node-negative cT1-T3 breast cancer patients with up to two sentinel lymph node macrometastases are randomised to undergo completion ALND or not. Both breast-conserving surgery and mastectomy are eligible interventions. Data from NKBC were extracted for the years 2016 and 2017, and patient and tumour characteristics compared with Swedish trial participants from the same years. Results Overall, 306 NKBC cases from non-participating and 847 NKBC cases from participating sites (excluding SENOMAC participants) were compared with 463 SENOMAC trial participants. Patients belonging to the middle age groups (p = 0.015), with smaller tumours (p = 0.013) treated by breast-conserving therapy (50.3 versus 47.1 versus 65.2%, p < 0.001) and less nodal tumour burden (only 1 macrometastasis in 78.8 versus 79.9 versus 87.3%, p = 0.001) were over-represented in the trial population. Time trends indicated, however, that differences may be mitigated over time. Conclusions This interim external validity analysis specifically addresses selection mechanisms during an ongoing trial, potentially increasing generalisability by the time full accrual is reached. Similar validity checks should be an integral part of prospective clinical trials. Trial registration: NCT 02240472, retrospective registration date September 14, 2015 after trial initiation on January 31, 2015
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| 5. |
- Jones, Clarer, et al.
(författare)
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Lymphatic filariasis transmission in Rufiji District, southeastern Tanzania : infection status of the human population and mosquito vectors after twelve rounds of mass drug administration
- 2018
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Ingår i: Parasites & Vectors. - : BMC. - 1756-3305. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundControl of lymphatic filariasis (LF) in most of the sub-Saharan African countries is based on annual mass drug administration (MDA) using a combination of ivermectin and albendazole. Monitoring the impact of this intervention is crucial for measuring the success of the LF elimination programmes. This study assessed the status of LF infection in Rufiji district, southeastern Tanzania after twelve rounds of MDA.MethodsCommunity members aged between 10 and 79 years were examined for Wuchereria bancrofti circulating filarial antigens (CFA) using immunochromatographic test cards (ICTs) and antigen-positive individuals were screened for microfilaraemia. All study participants were examined for clinical manifestation of LF and interviewed for drug uptake during MDA rounds. Filarial mosquito vectors were collected indoor and outdoor and examined for infection with W. bancrofti using a microscope and quantitative real-time polymerase chain reaction (qPCR) techniques.ResultsOut of 854 participants tested, nine (1.1%) were positive for CFA and one (0.1%) was found to be microfilaraemic. The prevalence of hydrocele and elephantiasis was 4.8% and 2.9%, respectively. Surveyed drug uptake rates were high, with 70.5% of the respondents reporting having swallowed the drugs in the 2014 MDA round (about seven months before this study). Further, 82.7% of the respondents reported having swallowed the drugs at least once since the inception of MDA programme in 2000. Of the 1054 filarial vectors caught indoors and dissected to detect W. bancrofti infection none was found to be infected. Moreover, analysis by qPCR of 1092 pools of gravid Culex quinquefasciatus collected outdoors resulted in an estimated infection rate of 0.1%. None of the filarial vectors tested with qPCR were found to be infective.ConclusionAnalysis of indices of LF infection in the human population and filarial mosquito vectors indicated a substantial decline in the prevalence of LF and other transmission indices, suggesting that local transmission was extremely low if occurring at all in the study areas. We, therefore, recommend a formal transmission assessment survey (TAS) to be conducted in the study areas to make an informed decision on whether Rufiji District satisfied WHO criteria for stopping MDA.
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| 6. |
- Ostherr, Kirsten, et al.
(författare)
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Architectures of Sustainability
- 2018
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Ingår i: Applied Media Studies. - New York: Routledge, Taylor & Francis Group, 2018. : Routledge. - 9781138202481 - 9781138578265 - 9781315473857 ; , s. 219-237
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Bokkapitel (refereegranskat)abstract
- While doing applied media studies generally requires far fewer financial resources than doing applied science, issues of funding and sustainability nonetheless play a significant role in these projects. The multidisciplinary teams assembled to create applied media projects need space, technology, supplies, and human capital to succeed, and the pipelines for securing those resources are particularly limited in the humanities. This chapter asks contributors how they have managed to attain the needed resources for their projects, and what kinds of institutional homes they have found to house them. Further, to cultivate the necessary team members as participants come and go, we discuss what kind of background, training, and mentoring of undergraduate and graduate students, as well as faculty members, is needed to do this kind of work.
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| 7. |
- Ostherr, Kirsten, et al.
(författare)
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Pleasures and Perils of Hands-On, Collaborative Work
- 2018
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Ingår i: Applied Media Studies. - New York: Routledge, Taylor & Francis Group, 2018. : Routledge. - 9781138202481 - 9781138578265 - 9781315473857 ; , s. 81-96
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Bokkapitel (refereegranskat)abstract
- In this collaboratively authored chapter, contributors discuss why they do applied media studies, addressing both the great rewards and the significant challenges to shifting away from traditional models of humanistic research and teaching.
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| 8. |
- Ostherr, Kirsten, et al.
(författare)
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Transdisciplinary Collaboration and Translational Media-Making
- 2018
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Ingår i: Applied Media Studies. - New York: Routledge, Taylor & Francis Group, 2018. : Routledge. - 9781138202481 - 9781138578265 - 9781315473857 ; , s. 129-140
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Bokkapitel (refereegranskat)abstract
- In this chapter, contributors address the core challenges of collaborating across academic divisions such as humanities and science, bridging academic and community practices, and translating between the diverse stakeholders involved in these projects. Much of the recent research on problem-based collaboration and innovation has noted the value of bringing together teams of people with radically different forms of expertise to solve complex challenges (Johnson 2010; Davidson 2011; Ness 2012). Contributors address a common question asked by academics interested in applied media studies, who don’t know where to begin: how do you find good collaborators in different, perhaps unfamiliar disciplines? Further, once those collaborators are found, how do you overcome the typical siloes of universities structured by departments within divisions like “humanities” and “sciences” to build effective working relationships with your collaborators? How do you translate between fields with radically different training, terminology, and theories of knowledge? What does it take to develop a shared vocabulary?
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| 9. |
- Ullmark, Peter, et al.
(författare)
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Design & visuell kommunikation : examensbok 2010
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Publiceras i samband med den första utexamineringen från kandidatprogrammet Design & Visuell Kommunikation på Malmö högskola. Boken innehåller artiklar om designforskning såväl som personliga presentationer av programmets studenter och deras examensarbeten eller portfolios. Boken definierar vad Design & Visuell Kommunikation står för i studenternas mening.
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