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| 2. |
- Stanaway, Jeffrey D., et al.
(författare)
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Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
- 2018
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Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1923-1994
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Tidskriftsartikel (refereegranskat)abstract
- Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk- outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017.
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| 3. |
- Engert, Andreas, et al.
(författare)
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The European Hematology Association Roadmap for European Hematology Research : a consensus document
- 2016
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Ingår i: Haematologica. - Pavia, Italy : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
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Tidskriftsartikel (refereegranskat)abstract
- The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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| 4. |
- Zamora, Juan Carlos, et al.
(författare)
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Considerations and consequences of allowing DNA sequence data as types of fungal taxa
- 2018
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Ingår i: IMA Fungus. - : INT MYCOLOGICAL ASSOC. - 2210-6340 .- 2210-6359. ; 9:1, s. 167-185
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Tidskriftsartikel (refereegranskat)abstract
- Nomenclatural type definitions are one of the most important concepts in biological nomenclature. Being physical objects that can be re-studied by other researchers, types permanently link taxonomy (an artificial agreement to classify biological diversity) with nomenclature (an artificial agreement to name biological diversity). Two proposals to amend the International Code of Nomenclature for algae, fungi, and plants (ICN), allowing DNA sequences alone (of any region and extent) to serve as types of taxon names for voucherless fungi (mainly putative taxa from environmental DNA sequences), have been submitted to be voted on at the 11th International Mycological Congress (Puerto Rico, July 2018). We consider various genetic processes affecting the distribution of alleles among taxa and find that alleles may not consistently and uniquely represent the species within which they are contained. Should the proposals be accepted, the meaning of nomenclatural types would change in a fundamental way from physical objects as sources of data to the data themselves. Such changes are conducive to irreproducible science, the potential typification on artefactual data, and massive creation of names with low information content, ultimately causing nomenclatural instability and unnecessary work for future researchers that would stall future explorations of fungal diversity. We conclude that the acceptance of DNA sequences alone as types of names of taxa, under the terms used in the current proposals, is unnecessary and would not solve the problem of naming putative taxa known only from DNA sequences in a scientifically defensible way. As an alternative, we highlight the use of formulas for naming putative taxa (candidate taxa) that do not require any modification of the ICN.
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| 5. |
- Abbafati, Cristiana, et al.
(författare)
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- 2020
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Ask, Karl, 1978, et al.
(författare)
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Approach, avoidance, and the perception of credibility
- 2020
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Ingår i: Open Psychology. - : Walter de Gruyter GmbH. - 2543-8883. ; 2:1, s. 3-21
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Tidskriftsartikel (refereegranskat)abstract
- Based on a functional approach to credibility judgments, the authors hypothesize that receivers’ judgments of senders’ credibility involve an evaluative dimension (i.e., good–bad) and are associated with approach and avoidance tendencies. In three experiments (total N = 645), participants (receivers) judged the credibility of suspects (senders) denying involvement in a mock theft. While watching or reading the message, receivers performed an approach-related (arm flexion) or an avoidance-related (arm extension) motor action. Although receivers’ affective evaluations of senders (good–bad) correlated strongly with credibility judgments in all three experiments, the results of the arm position manipulation were mixed. In Experiment 1, receivers in an arm flexion (vs. arm extension) state judged the sender as more credible, but only when informed beforehand about the upcoming credibility judgment. In Experiment 2 and 3, however, there was no evidence of an arm position effect on credibility judgments. A cross-experimental meta-analysis revealed that the effect of the manipulation was statistically indistinguishable from zero, Hedges’ g = 0.07, 95% CI [−0.09, 0.22], and provided strong support for the null hypothesis. Multiple interpretations of the results are discussed.
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| 7. |
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| 8. |
- Ask, Karl, 1978, et al.
(författare)
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Elasticity in evaluations of criminal evidence: Exploring the role of cognitive dissonance
- 2011
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Ingår i: Legal and Criminological Psychology. ; 16, s. 289-306
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Tidskriftsartikel (refereegranskat)abstract
- Purpose. Previous experiments have demonstrated asymmetrical scepticism in investigators' judgments of criminal evidence – evidence inconsistent (vs. consistent) with the dominant hypothesis about a case is judged as less reliable. In addition, some types of evidence (e.g., witness testimony) are more susceptible to asymmetrical scepticism than others (e.g., DNA evidence), indicating varying degrees of elasticity. This article proposes that inconsistent evidence arouses cognitive dissonance, and that the dissonance can be reduced through either asymmetrical scepticism (for high-elasticity evidence) or belief change (for low-elasticity evidence). The hypotheses are tested in two experiments. Methods. In both experiments, law students made a preliminary judgment about the guilt of a suspect in a homicide case, and subsequently received a piece of DNA or witness evidence which was either consistent or inconsistent with the preliminary judgment. The extent to which participants changed their guilt judgments, judged the additional evidence as reliable, and felt dissonance served as the main dependent variables. Results. Inconsistent (vs. consistent) evidence did arouse stronger dissonance, but only for witness (and not DNA) evidence. Experienced dissonance (Experiment 1) and dissonance reduction (Experiment 2) accounted for the effect of the evidence on changes in guilt judgments, but not for the effect on reliability judgments. The greatest dissonance reduction was observed among participants who received inconsistent witness evidence but did not change their guilt judgments accordingly. Conclusions. It appears that dissonance plays a significant, although complex, role in investigative judgments of guilt and reliability. Alternative dissonance-reducing mechanisms that can account for the findings and practical implications are discussed.
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| 9. |
- Ask, Karl, 1978, et al.
(författare)
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On the Ease of (Dis)believing: The Role of Accessibility Experiences in Credibility Judgments
- 2012
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Ingår i: Applied Cognitive Psychology. - : Wiley. - 1099-0720 .- 0888-4080. ; 26:5, s. 779-784
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Tidskriftsartikel (refereegranskat)abstract
- Credibility judgments are common and consequential in many applied settings. Although much research has addressed human observers’ ability to discriminate true and deceptive statements, less is known about the psychological processes involved in such judgments. Here, it is proposed that the process of mustering evidence for or against credibility is reflected in a feeling-based form (ease-of-retrieval) and that such feelings can be used as a basis for credibility judgments. The results of an experiment show, as predicted, that the perceived ease with which participants could identify clues strongly influenced credibility judgments. Ironically, mustering more clues in support of a truthful account lowered credibility judgments; in contrast, mustering more clues in support of a deceptive account increased credibility judgments. Mediation analyses suggest that this is because participants relied on a feeling-based as opposed to content-based judgment strategy. Practical implications are discussed, and theoretical issues regarding the process of credibility judgment are raised.
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| 10. |
- Ask, Karl, 1978, et al.
(författare)
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The effects of approach and avoidance states on lie-detection accuracy
- 2017
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Ingår i: 18th General Meeting of the European Association of Social Psychology, Granada, Spain, 5-8 July, 2017.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Three experiments examined perceivers’ lie-detection performance under different self-regulatory states. Overall, participants in approach and avoidance states did not differ in their ability to discriminate between truthful and deceptive messages, but approach participants displayed impaired performance relative to controls.
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