| 1. |
- Bednar, Peter, et al.
(författare)
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Conquering Complex and Changing Systems through Recognition of Individual Uniqueness
- 2007
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Ingår i: Proceedings of the 6th European Conference on Research Methodology for Business and Management Studies. - 9781905305513 ; , s. 51-56
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Konferensbidrag (refereegranskat)abstract
- From the point of view of each individual’s sense-making, an organization is an emergent property of inter-individual sense-making processes and activities. The organization is a result of emergence from individual sense-making perspectives. A critically informed approach to research involves recognition / understanding of this emergence. Without the recognition of the uniqueness of each particular individual’s experience of organizational life this critical approach may be undermined. Within a logical empiricist tradition (LE), the focus of a researcher’s attention rests on increasing the precision and clarity with which a problem situation may be expressed. This can lead to an artificial separation of theory from praxis, of observation from observer and observed. ‘Knowing’ about organizational context may be deeply embedded and inaccessible to individuals concerned. Knowing is formed by on-going construction of meanings through synthesis of new data with past experience. A hermeneutic-dialectics (HD) perspective emphasises self-awareness of human individuals. It goes towards emancipation and transparency rather than clarity and precision. A researcher adopting an HD perspective will recognize that there are ambiguities inherent in socially-constructed world views. Critical Systemic Thinking assumes a critical position with regard to informed academic practices. However, a problem for critically-informed research is also a pedagogical one. The research audience needs not only to be engaged in a dialogue regarding a transformation of modern research practices, but also needs to be informed about which foundations these practices supposedly draw upon. So there is a two-fold challenge: the subject-matter of research, and unfamiliarity with critical perspectives by the audience for that research. It may be difficult to establish a dialogue with regard to critical of ways of thinking, if those ways are unknown to the audience.
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| 2. |
- Bednar, Peter, et al.
(författare)
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Dealing with Complexity in Knowledge Sharing Processes’
- 2007
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Ingår i: [Host publication title missing]. - 9781905305537 ; , s. 101-108
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Konferensbidrag (refereegranskat)abstract
- In a context of complex problem spaces, human individuals need support to carry out in-depth inquiry, generating many, diverse possibilities, without suffering from information overload. In earlier work, we have demonstrated the potential of a model of four-valued logic to provide support in a knowledge sharing environment by codifying, not knowledge, but categories of argument/assertion. In this paper, we extend the application of our model to a second order. In the first application, individually-created narratives are categorised according to four-valued logic: assertions of positive belief in alternatives, negative belief in alternatives, possibility of alternatives or ignorance of any alternative. A second order is illustrated through an example in which all assertions of positive or optimistic possible belief are considered by participants. The model is applied in order to identify clusters of narratives which appear to have characteristics in common, by creation of diversity networks. In this way, a more focused agenda for debate can be supported to emerge.
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| 3. |
- Bednar, Peter, et al.
(författare)
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Facilitating IS capability – towards a new perspective on governance
- 2007
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Ingår i: [Host publication title missing]. - 9781905305421 ; , s. 25-34
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Konferensbidrag (refereegranskat)abstract
- It has been suggested that those organizations which have greatest competitive success are those in which information systems strategy is seen as integral to overall business strategy. Thus, the CIO is seen as a full member of the management team, and not as someone presiding over a separate functional area which provides a service to the rest. There is a need therefore for businesses to avoid such fragmentation, and to develop information systems ‘capability’, empowering all members of the organization to harness these resources effectively. At the same time, many firms are concerned to become leaner and more efficient by outsourcing some activities seen to be non-core. There is a need for those involved in IS governance to make choices which strike a balance between efficiency and effectiveness, in order to develop IS ‘capability’. In this paper, the authors discuss a need to reconsider perspectives on management of IS, from a leadership approach to one of facilitation. People at all levels must be empowered and supported to make the best use of available technologies, and information, by developing their own IS ‘capability’. The concept of IS governance, therefore, needs to be seen as a concern for the whole organization and not just the province of the CIO. Technical professionals have sometimes been regarded as the experts, who will put suitable systems in place on behalf of users. The authors believe that greater benefits can be gained by going beyond consultation with users, and encouraging collaborative design, in which individuals can be supported to shape their own requirements, and to own and control development of their own IS capability. The paper will discuss methods which we believe may provide appropriate support for individuals to achieve this.
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| 4. |
- Czerw, Tomasz, et al.
(författare)
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Impact of donor-derived CD34+infused cell dose on outcomes of patients undergoing allo-HCT following reduced intensity regimen for myelofibrosis: a study from the Chronic Malignancies Working Party of the EBMT
- 2022
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Ingår i: Bone Marrow Transplantation. - : SPRINGER NATURE. - 0268-3369 .- 1476-5365. ; 57, s. 261-270
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Tidskriftsartikel (refereegranskat)abstract
- The optimal CD34 + cell dose in the setting of RIC allo-HCT for myelofibrosis (MF) remains unknown. We retrospectively analyzed 657 patients with primary or secondary MF transplanted with use of peripheral blood (PB) stem cells after fludarabine/melphalan or fludarabine/busulfan RIC regimen. Median patient age was 58 (range, 22-76) years. Donors were HLA-identical sibling (MSD) or unrelated (UD). Median follow-up was 46 (2-194) months. Patients transplanted with higher doses of CD34 + cells (>7.0 x 10(6)/kg), had an increased chance of achievement of both neutrophil (hazard ratio (HR), 1.46; P < 0.001) and platelet engraftment (HR, 1.43; P < 0.001). In a model with interaction, for patients transplanted from a MSD, higher CD34 + dose was associated with improved overall survival (HR, 0.63; P = 0.04) and relapse-free survival (HR, 0.61; P = 0.02), lower risk of non-relapse mortality (HR, 0.57; P = 0.04) and higher rate of platelet engraftment. The combined effect of higher cell dose and UD was apparent only for higher neutrophil and platelet recovery rate. We did not document any detrimental effect of high CD34 + dose on transplant outcomes. More bulky splenomegaly was an adverse factor for survival, engraftment and NRM. Our analysis suggests a potential benefit for MF patients undergoing RIC PB-allo-HCT receiving more than 7.0 x 10(6)/kg CD34 + cells.
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| 5. |
- Robin, Marie, et al.
(författare)
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Antilymphocyte globulin for matched sibling donor transplantation in patients with myelofibrosis
- 2019
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Ingår i: Haematologica. - : FERRATA STORTI FOUNDATION. - 0390-6078 .- 1592-8721. ; 104:6, s. 1230-1236
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Tidskriftsartikel (refereegranskat)abstract
- The use of antihuman T-lymphocyte immunoglobulin in the setting of transplantation from an HLA-matched related donor is still much debated. Acute and chronic graft-versus-host disease are the main causes of morbidity and mortality after allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis. The aim of this study was to evaluate the effect of antihuman T-lymphocyte immunoglobulin in a large cohort of patients with myelofibrosis (n= 287). The cumulative incidences of grade II-IV acute graft-versus-host disease among patients who were or were not given antihuman T-lymphocyte immunoglobulin were 26% and 41%, respectively. The corresponding incidences of chronic graft-versus-host disease were 52% and 55%, respectively. Non-adjusted overall survival, disease-free survival and non-relapse mortality rates were 55% versus 53%, 49% versus 45%, and 32% versus 31%, respectively, among the patients who were or were not given antihuman T-lymphocyte immunoglobulin. An adjusted model confirmed that the risk of acute graft-versus-host disease was lower following antihuman T-lymphocyte immunoglobulin (hazard ratio, 0.54; P= 0.010) while it did not decrease the risk of chronic graft-versus-host disease. The hazard ratios for overall survival and non-relapse mortality were 0.66 and 0.64, with P-values of 0.05 and 0.09, respectively. Antihuman T-lymphocyte immunoglobulin did not influence disease-free survival, graft-versus-host disease, relapse-free survival or relapse risk. In conclusion, in the setting of matched related transplantation in myelofibrosis patients, this study demonstrates that antihuman T-lymphocyte immunoglobulin decreases the risk of acute graft-versushost disease without increasing the risk of relapse.
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