| 1. |
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| 2. |
- Forrest, ARR, et al.
(författare)
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A promoter-level mammalian expression atlas
- 2014
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 507:7493, s. 462-
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Goffeng, Magnus C H T, 1987, et al.
(författare)
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Shift–tail equivalence and an unbounded representative of the Cuntz–Pimsner extension
- 2018
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Ingår i: Ergodic Theory and Dynamical Systems. - : Cambridge University Press (CUP). - 0143-3857 .- 1469-4417. ; 38:4, s. 1389-1421
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Tidskriftsartikel (refereegranskat)abstract
- We show how the fine structure in shift–tail equivalence, appearing in the non-commutative geometry of Cuntz–Krieger algebras developed by the first two listed authors, has an analogue in a wide range of other Cuntz–Pimsner algebras. To illustrate this structure, and where it appears, we produce an unbounded representative of the defining extension of the Cuntz–Pimsner algebra constructed from a finitely generated projective bi-Hilbertian module, extending work by the third listed author with Robertson and Sims. As an application, our construction yields new spectral triples for Cuntz and Cuntz–Krieger algebras and for Cuntz–Pimsner algebras associated to vector bundles twisted by an equicontinuous (Formula presented.)-automorphism.
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| 4. |
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| 5. |
- Asim, M, et al.
(författare)
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Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer
- 2017
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1, s. 374-
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Tidskriftsartikel (refereegranskat)abstract
- Emerging data demonstrate homologous recombination (HR) defects in castration-resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here we demonstrate a direct requirement for the androgen receptor (AR) to maintain HR gene expression and HR activity in prostate cancer. We show that PARP-mediated repair pathways are upregulated in prostate cancer following androgen-deprivation therapy (ADT). Furthermore, upregulation of PARP activity is essential for the survival of prostate cancer cells and we demonstrate a synthetic lethality between ADT and PARP inhibition in vivo. Our data suggest that ADT can functionally impair HR prior to the development of castration resistance and that, this potentially could be exploited therapeutically using PARP inhibitors in combination with androgen-deprivation therapy upfront in advanced or high-risk prostate cancer.
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| 6. |
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| 7. |
- Blunden, Jessica, et al.
(författare)
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State of the climate in 2013
- 2014
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Ingår i: Bulletin of the American Meteorological Society. - 0003-0007. ; 95
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Tidskriftsartikel (refereegranskat)abstract
- © 2014, American Meteorological Society. All rights reserved. In 2013, the vast majority of the monitored climate variables reported here maintained trends established in recent decades. ENSO was in a neutral state during the entire year, remaining mostly on the cool side of neutral with modest impacts on regional weather patterns around the world. This follows several years dominated by the effects of either La Niña or El Niño events. According to several independent analyses, 2013 was again among the 10 warmest years on record at the global scale, both at the Earth’s surface and through the troposphere. Some regions in the Southern Hemisphere had record or near-record high temperatures for the year. Australia observed its hottest year on record, while Argentina and New Zealand reported their second and third hottest years, respectively. In Antarctica, Amundsen-Scott South Pole Station reported its highest annual temperature since records began in 1957. At the opposite pole, the Arctic observed its seventh warmest year since records began in the early 20th century. At 20-m depth, record high temperatures were measured at some permafrost stations on the North Slope of Alaska and in the Brooks Range. In the Northern Hemisphere extratropics, anomalous meridional atmospheric circulation occurred throughout much of the year, leading to marked regional extremes of both temperature and precipitation. Cold temperature anomalies during winter across Eurasia were followed by warm spring temperature anomalies, which were linked to a new record low Eurasian snow cover extent in May. Minimum sea ice extent in the Arctic was the sixth lowest since satellite observations began in 1979. Including 2013, all seven lowest extents on record have occurred in the past seven years. Antarctica, on the other hand, had above-average sea ice extent throughout 2013, with 116 days of new daily high extent records, including a new daily maximum sea ice area of 19.57 million km2 reached on 1 October. ENSO-neutral conditions in the eastern central Pacific Ocean and a negative Pacific decadal oscillation pattern in the North Pacific had the largest impacts on the global sea surface temperature in 2013. The North Pacific reached a historic high temperature in 2013 and on balance the globally-averaged sea surface temperature was among the 10 highest on record. Overall, the salt content in nearsurface ocean waters increased while in intermediate waters it decreased. Global mean sea level continued to rise during 2013, on pace with a trend of 3.2 mm yr-1 over the past two decades. A portion of this trend (0.5 mm yr-1) has been attributed to natural variability associated with the Pacific decadal oscillation as well as to ongoing contributions from the melting of glaciers and ice sheets and ocean warming. Global tropical cyclone frequency during 2013 was slightly above average with a total of 94 storms, although the North Atlantic Basin had its quietest hurricane season since 1994. In the Western North Pacific Basin, Super Typhoon Haiyan, the deadliest tropical cyclone of 2013, had 1-minute sustained winds estimated to be 170 kt (87.5 m s-1) on 7 November, the highest wind speed ever assigned to a tropical cyclone. High storm surge was also associated with Haiyan as it made landfall over the central Philippines, an area where sea level is currently at historic highs, increasing by 200 mm since 1970. In the atmosphere, carbon dioxide, methane, and nitrous oxide all continued to increase in 2013. As in previous years, each of these major greenhouse gases once again reached historic high concentrations. In the Arctic, carbon dioxide and methane increased at the same rate as the global increase. These increases are likely due to export from lower latitudes rather than a consequence of increases in Arctic sources, such as thawing permafrost. At Mauna Loa, Hawaii, for the first time since measurements began in 1958, the daily average mixing ratio of carbon dioxide exceeded 400 ppm on 9 May. The state of these variables, along with dozens of others, and the 2013 climate conditions of regions around the world are discussed in further detail in this 24th edition of the State of the Climate series.
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| 8. |
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| 9. |
- Forsyth, Iain, et al.
(författare)
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Boundaries, spectral triples and K-homology
- 2019
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Ingår i: Journal of Noncommutative Geometry. - 1661-6952 .- 1661-6960. ; 13:2, s. 407-472
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Tidskriftsartikel (refereegranskat)abstract
- © European Mathematical Society This paper extends the notion of a spectral triple to a relative spectral triple, an unbounded analogue of a relative Fredholm module for an ideal J G A. Examples include manifolds with boundary, manifolds with conical singularities, dimension drop algebras, -deformations and Cuntz–Pimsner algebras of vector bundles. The bounded transform of a relative spectral triple is a relative Fredholm module, making the image of a relative spectral triple under the boundary mapping in K-homology easy to compute. We introduce an additional operator called a Clifford normal with which a relative spectral triple can be doubled into a spectral triple. The Clifford normal also provides a boundary Hilbert space, a representation of the quotient algebra, a boundary Dirac operator and an analogue of the Calderon projection. In the examples this data does assemble to give a boundary spectral triple, though we can not prove this in general. When we do obtain a boundary spectral triple, we provide sufficient conditions for the boundary triple to represent the K-homological boundary. Thus we abstract the proof of Baum–Douglas–Taylor’s “boundary of Dirac is Dirac on the boundary” theorem into the realm of non-commutative geometry.
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| 10. |
- Goffeng, Magnus C H T, 1987, et al.
(författare)
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Constructing KMS states from infinite-dimensional spectral triples
- 2019
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Ingår i: Journal of Geometry and Physics. - : Elsevier BV. - 0393-0440. ; 143, s. 107-149
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Tidskriftsartikel (refereegranskat)abstract
- We construct KMS-states from Li1-summable semifinite spectral triples and show that in several important examples the construction coincides with well-known direct constructions of KMS-states for naturally defined flows. Under further summability assumptions the constructed KMS-state can be computed in terms of Dixmier traces. For closed manifolds, we recover the ordinary Lebesgue integral. For Cuntz–Pimsner algebras with their gauge flow, the construction produces KMS-states from traces on the coefficient algebra and recovers the Laca–Neshveyev correspondence. For a discrete group acting on its Stone–Čech boundary, we recover the Patterson–Sullivan measures on the Stone-Čech boundary for a flow defined from the Radon–Nikodym cocycle.
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