| 1. |
- Stacey, Simon N, et al.
(author)
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A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.
- 2011
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 43:11, s. 1098-103
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Journal article (peer-reviewed)abstract
- To identify new risk variants for cutaneous basal cell carcinoma, we performed a genome-wide association study of 16 million SNPs identified through whole-genome sequencing of 457 Icelanders. We imputed genotypes for 41,675 Illumina SNP chip-typed Icelanders and their relatives. In the discovery phase, the strongest signal came from rs78378222[C] (odds ratio (OR) = 2.36, P = 5.2 × 10(-17)), which has a frequency of 0.0192 in the Icelandic population. We then confirmed this association in non-Icelandic samples (OR = 1.75, P = 0.0060; overall OR = 2.16, P = 2.2 × 10(-20)). rs78378222 is in the 3' untranslated region of TP53 and changes the AATAAA polyadenylation signal to AATACA, resulting in impaired 3'-end processing of TP53 mRNA. Investigation of other tumor types identified associations of this SNP with prostate cancer (OR = 1.44, P = 2.4 × 10(-6)), glioma (OR = 2.35, P = 1.0 × 10(-5)) and colorectal adenoma (OR = 1.39, P = 1.6 × 10(-4)). However, we observed no effect for breast cancer, a common Li-Fraumeni syndrome tumor (OR = 1.06, P = 0.57, 95% confidence interval 0.88-1.27).
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| 3. |
- Alminger, Marie, 1957, et al.
(author)
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In Vitro Models for Studying Secondary Plant Metabolite Digestion and Bioaccessibility
- 2014
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In: Comprehensive Reviews in Food Science and Food Safety. - : Wiley. - 1541-4337. ; 13:4, s. 413-436
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Research review (peer-reviewed)abstract
- There is an increased interest in secondary plant metabolites, such as polyphenols and carotenoids, due to their proposed health benefits. Much attention has focused on their bioavailability, a prerequisite for further physiological functions. As human studies are time consuming, costly, and restricted by ethical concerns, in vitro models for investigating the effects of digestion on these compounds have been developed and employed to predict their release from the food matrix, bioaccessibility, and assess changes in their profiles prior to absorption. Most typically, models simulate digestion in the oral cavity, the stomach, the small intestine, and, occasionally, the large intestine. A plethora of models have been reported, the choice mostly driven by the type of phytochemical studied, whether the purpose is screening or studying under close physiological conditions, and the availability of the model systems. Unfortunately, the diversity of model conditions has hampered the ability to compare results across different studies. For example, there is substantial variability in the time of digestion, concentrations of salts, enzymes, and bile acids used, pH, the inclusion of various digestion stages; and whether chosen conditions are static (with fixed concentrations of enzymes, bile salts, digesta, and so on) or dynamic (varying concentrations of these constituents). This review presents an overview of models that have been employed to study the digestion of both lipophilic and hydrophilic phytochemicals, comparing digestive conditions in vitro and in vivo and, finally, suggests a set of parameters for static models that resemble physiological conditions.
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| 4. |
- Ginsburg, A., et al.
(author)
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Dense gas in the Galactic central molecular zone is warm and heated by turbulence
- 2016
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 586, s. Art nr A50-
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Journal article (peer-reviewed)abstract
- Context. The Galactic center is the closest region where we can study star formation under extreme physical conditions like those in high-redshift galaxies. Aims. We measure the temperature of the dense gas in the central molecular zone (CMZ) and examine what drives it. Methods. We mapped the inner 300 pc of the CMZ in the temperature-sensitive J = 3-2 para-formaldehyde (p-H2CO) transitions. We used the 3(2,1)-2(2,0)/3(0,3)-2(0,2) line ratio to determine the gas temperature in n similar to 10(4) - 10(5) cm(-3) gas. We have produced temperature maps and cubes with 30 0 0 and 1 km s(-1) resolution and published all data in FITS form. Results. Dense gas temperatures in the Galactic center range from similar to 60 K to > 100 K in selected regions. The highest gas temperatures T-G > 100 K are observed around the Sgr B2 cores, in the extended Sgr B2 cloud, the 20 km s(-1) and 50 km s(-1) clouds, and in "The Brick" (G0.253 + 0.016). We infer an upper limit on the cosmic ray ionization rate zeta(CR)
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| 5. |
- Munoz-Gil, G., et al.
(author)
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Objective comparison of methods to decode anomalous diffusion
- 2021
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Journal article (peer-reviewed)abstract
- Deviations from Brownian motion leading to anomalous diffusion are found in transport dynamics from quantum physics to life sciences. The characterization of anomalous diffusion from the measurement of an individual trajectory is a challenging task, which traditionally relies on calculating the trajectory mean squared displacement. However, this approach breaks down for cases of practical interest, e.g., short or noisy trajectories, heterogeneous behaviour, or non-ergodic processes. Recently, several new approaches have been proposed, mostly building on the ongoing machine-learning revolution. To perform an objective comparison of methods, we gathered the community and organized an open competition, the Anomalous Diffusion challenge (AnDi). Participating teams applied their algorithms to a commonly-defined dataset including diverse conditions. Although no single method performed best across all scenarios, machine-learning-based approaches achieved superior performance for all tasks. The discussion of the challenge results provides practical advice for users and a benchmark for developers. Deviations from Brownian motion leading to anomalous diffusion are ubiquitously found in transport dynamics but often difficult to characterize. Here the authors compare approaches for single trajectory analysis through an open competition, showing that machine learning methods outperform classical approaches.
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| 8. |
- Alder-Rangel, Alene, et al.
(author)
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The Third International Symposium on Fungal Stress – ISFUS
- 2020
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In: Fungal Biology. - : Elsevier BV. - 1878-6146. ; 124:5, s. 235-252
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Journal article (peer-reviewed)abstract
- Stress is a normal part of life for fungi, which can survive in environments considered inhospitable or hostile for other organisms. Due to the ability of fungi to respond to, survive in, and transform the environment, even under severe stresses, many researchers are exploring the mechanisms that enable fungi to adapt to stress. The International Symposium on Fungal Stress (ISFUS) brings together leading scientists from around the world who research fungal stress. This article discusses presentations given at the third ISFUS, held in São José dos Campos, São Paulo, Brazil in 2019, thereby summarizing the state-of-the-art knowledge on fungal stress, a field that includes microbiology, agriculture, ecology, biotechnology, medicine, and astrobiology.
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| 9. |
- Ao, Y., et al.
(author)
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The thermal state of molecular clouds in the Galactic center: evidence for non-photon-driven heating
- 2014
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In: Proceedings of the International Astronomical Union. - 1743-9213 .- 1743-9221. ; 9:S303, s. 89-91
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Journal article (peer-reviewed)abstract
- We have used the Atacama Pathfinder Experiment (APEX) 12 m telescope at 218 GHz to observe molecular clouds simultaneously in the J_KA,Kc=3_03→2_02,3_22→2_21,and 3_21→2_20 transitions of para-H2CO to determine kinetic temperatures of the dense gas in the central molecular zone of the Galaxy. Gas kinetic temperatures for individual molecular clouds range from 55 to 125 K or even higher. The molecular clouds at high temperatures may be heated by turbulent dissipation and/or cosmic-rays
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| 10. |
- Ao, Y., et al.
(author)
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The thermal state of molecular clouds in the Galactic center: evidence for non-photon-driven heating
- 2013
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 550
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Journal article (peer-reviewed)abstract
- We used the Atacama Pathfinder Experiment (APEX) 12 m telescope to observe the J(KAKc) = 3(03) -> 2(02), 3(22) -> 2(21), and 3(21) -> 2(20) transitions of para-H2CO at 218 GHz simultaneously to determine kinetic temperatures of the dense gas in the central molecular zone (CMZ) of our Galaxy. The map extends over approximately 40' x 8' (similar to 100 x 20 pc(2)) along the Galactic plane with a linear resolution of 1.2 pc. The strongest of the three lines, the H2CO (3(03) -> 2(02)) transition, is found to be widespread, and its emission shows a spatial distribution similar to ammonia. The relative abundance of para-H2CO is 0.5 - 1.2 x 10(-9), which is consistent with results from lower frequency H2CO absorption lines. Derived gas kinetic temperatures for individual molecular clouds range from 50K to values in excess of 100 K. While a systematic trend toward (decreasing) kinetic temperature versus (increasing) angular distance from the Galactic center (GC) is not found, the clouds with highest temperature (T-kin > 100 K) are all located near the nucleus. For the molecular gas outside the dense clouds, the average kinetic temperature is 65 +/- 10 K. The high temperatures of molecular clouds on large scales in the GC region may be driven by turbulent energy dissipation and / or cosmic-rays instead of photons. Such a non-photon-driven thermal state of the molecular gas provides an excellent template for the more distant vigorous starbursts found in ultraluminous infrared galaxies (ULIRGs).
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