| 1. |
- Labit, B., et al.
(författare)
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Dependence on plasma shape and plasma fueling for small edge-localized mode regimes in TCV and ASDEX Upgrade
- 2019
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:8
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Tidskriftsartikel (refereegranskat)abstract
- © 2019 Institute of Physics Publishing. All rights reserved. Within the EUROfusion MST1 work package, a series of experiments has been conducted on AUG and TCV devices to disentangle the role of plasma fueling and plasma shape for the onset of small ELM regimes. On both devices, small ELM regimes with high confinement are achieved if and only if two conditions are fulfilled at the same time. Firstly, the plasma density at the separatrix must be large enough (ne,sep/nG ∼ 0.3), leading to a pressure profile flattening at the separatrix, which stabilizes type-I ELMs. Secondly, the magnetic configuration has to be close to a double null (DN), leading to a reduction of the magnetic shear in the extreme vicinity of the separatrix. As a consequence, its stabilizing effect on ballooning modes is weakened.
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| 2. |
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| 3. |
- Yavorskij, V., et al.
(författare)
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TF ripple effects on the NBI deuteron confinement in JET
- 2007
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Ingår i: 34th EPS Conference on Plasma Physics 2007, EPS 2007 - Europhysics Conference Abstracts. - 9781622763344 ; , s. 876-879
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Konferensbidrag (refereegranskat)abstract
- Ripple induced reduction of the fluxes of deuterium neutrals in the 5-40 keV energy range from the plasma mid-plane was observed in recent JET experiments. The maximum observed reduction of D0 fluxes due to ripple is approximately 50 % and occurs at energies above 30 keV. In positive shear plasmas without ICRH ripple reduction of D0 fluxes vanishes at energies below 10 keV. However, in the case of plasmas with low or reversed shear core, increased D0 fluxes were observed for energies below 10-20 keV in the presence of additional ripple and ICRH heating. Interpretive modeling of the deuterium neutral emission that accounts for the superbanana ripple diffusion of NBI ions is in reasonable agreement with measurements at least for the scenarios without ICRH. Note that ripples may essentially effect the fast ion confinement in ITER where TF ripple magnitude at the outer separatrix is expected to be δ ∼ 0.5%.
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| 4. |
- Yavorskij, V., et al.
(författare)
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Results of Predictive Fokker-Planck Modelling of NBI Deuterons in ITER
- 2011
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Ingår i: Journal of fusion energy. - : Springer Science and Business Media LLC. - 0164-0313 .- 1572-9591. ; 30:4, s. 307-322
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Tidskriftsartikel (refereegranskat)abstract
- First an analytical formalism is presented for calculating the source distribution of ions generated by neutral beam injection (NBI) in tokamak plasmas. A general NBI ion source term, applicable to studies in the phase space up to 6 dimensions, is provided for neutral beams with finite thickness and divergence. Further, using this source term for the envisaged NBI in ITER, we carry out 3D Fokker-Planck modelling of the steady-state deuteron distribution function of NBI produced fast deuterons relaxing on bulk plasma components. For two basic ITER scenarios we demonstrate the poloidal profiles of the beam deuteron density, of the NBI generated current as well as of the NBI power deposition to bulk electrons and ions. Further, we evaluate the capability of gamma and NPA diagnostics of NBI ions in ITER and demonstrate the sensitivity of the distributions of NBI generated ions to different ITER operation scenarios.
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| 5. |
- Ziegler, P., et al.
(författare)
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A primary nasopharyngeal three-dimensional air-liquid interface cell culture model of the pseudostratified epithelium reveals differential donor- and cell type-specific susceptibility to Epstein-Barr virus infection
- 2021
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Ingår i: Plos Pathogens. - : Public Library of Science (PLoS). - 1553-7366 .- 1553-7374. ; 17:4
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Tidskriftsartikel (refereegranskat)abstract
- Epstein-Barr virus (EBV) is a ubiquitous gamma-herpesvirus with latent and lytic cycles. EBV replicates in the stratified epithelium but the nasopharynx is also composed of pseudostratified epithelium with distinct cell types. Latent infection is associated with nasopharyngeal carcinoma (NPC). Here, we show with nasopharyngeal conditionally reprogrammed cells cultured at the air-liquid interface that pseudostratified epithelial cells are susceptible to EBV infection. Donors varied in susceptibility to de novo EBV infection, but susceptible cultures also displayed differences with respect to pathogenesis. The cultures from one donor yielded lytic infection but cells from two other donors were positive for EBV-encoded EBERs and negative for other lytic infection markers. All cultures stained positive for the pseudostratified markers CK7, MUC5AC, alpha-tubulin in cilia, and the EBV epithelial cell receptor Ephrin receptor A2. To define EBV transcriptional programs by cell type and to elucidate latent/lytic infection-differential changes, we performed single cell RNA-sequencing on one EBV-infected culture that resulted in alignment with many EBV transcripts. EBV transcripts represented a small portion of the total transcriptome (similar to 0.17%). All cell types in the pseudostratified epithelium had detectable EBV transcripts with suprabasal cells showing the highest number of reads aligning to many EBV genes. Several restriction factors (IRF1, MX1, STAT1, C18orf25) known to limit lytic infection were expressed at lower levels in the lytic subcluster. A third of the differentially-expressed genes in NPC tumors compared to an uninfected pseudostratified ALI culture overlapped with the differentially-expressed genes in the latent subcluster. A third of these commonly perturbed genes were specific to EBV infection and changed in the same direction. Collectively, these findings suggest that the pseudostratified epithelium could harbor EBV infection and that the pseudostratified infection model mirrors many of the transcriptional changes imposed by EBV infection in NPC. Author summary It has been known for over 50 years that EBV latent infection is associated with NPC. Despite many advances from studies in 2-dimensional cell culture, many aspects of EBV molecular pathogenesis in the nasopharynx remain undefined because the cell types and the biology of the nasopharyngeal epithelium can only be faithfully captured in 3-dimensional cell culture. In the stratified epithelium, cellular differentiation triggers lytic infection but it is not clear to what degree the pseudostratified epithelium is involved. The pseudostratified epithelium is abundant in the lateral wall where the lymphoid-rich fossa of Rosenmuller is located and is a site where NPC tumors most often arises. While the oral epithelium is a site of EBV replication, whether the nasopharyngeal epithelium is a major source of EBV shedding in the nasopharynx is not well defined. Here, we present a 3-dimensional organoid model of the nasopharyngeal pseudostratified epithelium showing that such cells can be infected with EBV in some donor cultures, with examples of both latent and lytic infection. We propose that the cell types of the pseudostratified epithelium should be considered a component of EBV pathogenesis in the nasopharynx and that the difference in donor susceptibility and latent/lytic infection could influence EBV's fitness in the nasopharynx.
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