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1.	Bernstein, Michael H, et al. (author) Are conditioned open placebos feasible as an adjunctive treatment to opioids? : results from a single-group dose-extender pilot study with acute pain patients 2019 In: Psychotherapy and Psychosomatics. - : S. Karger. - 0033-3190 .- 1423-0348. ; 88:6, s. 380-382 Journal article (peer-reviewed)
2.	Bernstein, Michael H, et al. (author) How do US orthopaedic surgeons view placebo-controlled surgical trials? : A pilot online survey study 2022 In: Journal of Medical Ethics. - : BMJ Publishing Group Ltd. - 0306-6800 .- 1473-4257. Journal article (peer-reviewed)abstract Randomised placebo-controlled trials (RPCTs) are the gold standard for evaluating novel treatments. However, this design is rarely used in the context of orthopaedic interventions where participants are assigned to a real or placebo surgery. The present study examines attitudes towards RPCTs for orthopaedic surgery among 687 orthopaedic surgeons across the USA. When presented with a vignette describing an RPCT for orthopaedic surgery, 52.3% of participants viewed it as 'completely' or 'mostly' unethical. Participants were also asked to rank-order the value of five different types of evidence supporting the efficacy of a surgery, ranging from RPCT to an anecdotal report. Responses regarding RPCTs were polarised with 26.4% viewing it as the least valuable (even less valuable than an anecdote) and 35.7 .% viewing it as the most valuable. Where equipoise exists, if we want to subject orthopaedic surgeries to the highest standard of evidence (RPCTs) before they are implemented in clinical practice, it will be necessary to educate physicians on the value and ethics of placebo surgery control conditions. Otherwise, invasive procedures may be performed without any benefits beyond possible placebo effects.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Blease, Charlotte (2); Bernstein, Michael H (2); Magill, Molly (2); Rich, Josiah D (2); Beaudoin, Francesca ... (2); Savulescu, Julian (1); show more...; Weiss, Arnold-Peter (1); Kaptchuk, Ted J (1); Kirsch, Irving (1); Becker, Sara (1); Mach, Steven (1); Rosenfield, Maayan N (1); Terek, Richard M (1); Wartolowska, Karolin ... (1); show less...

University: Uppsala University (2)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Social Sciences (1)

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