| 1. |
- Perez-Nadales, Elena, et al.
(författare)
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Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales : The impact of cytomegalovirus disease and lymphopenia
- 2020
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Ingår i: American Journal of Transplantation. - : WILEY. - 1600-6135 .- 1600-6143. ; 20:6, s. 1629-1641
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Tidskriftsartikel (refereegranskat)abstract
- Treatment of carbapenemase-producing Enterobacterales bloodstream infections in solid organ transplant recipients is challenging. The objective of this study was to develop a specific score to predict mortality in solid organ transplant recipients with carbapenemase-producing Enterobacterales bloodstream infections. A multinational, retrospective (2004-2016) cohort study (INCREMENT-SOT, ClinicalTrials.gov NCT02852902) was performed. The main outcome variable was 30-day all-cause mortality. The INCREMENT-SOT-CPE score was developed using logistic regression. The global cohort included 216 patients. The final logistic regression model included the following variables: INCREMENT-CPE mortality score >= 8 (8 points), no source control (3 points), inappropriate empirical therapy (2 points), cytomegalovirus disease (7 points), lymphopenia (4 points), and the interaction between INCREMENT-CPE score >= 8 and CMV disease (minus 7 points). This score showed an area under the receiver operating characteristic curve of 0.82 (95% confidence interval [CI] 0.76-0.88) and classified patients into 3 strata: 0-7 (low mortality), 8-11 (high mortality), and 12-17 (very-high mortality). We performed a stratified analysis of the effect of monotherapy vs combination therapy among 165 patients who received appropriate therapy. Monotherapy was associated with higher mortality only in the very-high (adjusted hazard ratio [HR] 2.82, 95% CI 1.13-7.06, P = .03) and high (HR 9.93, 95% CI 2.08-47.40, P = .004) mortality risk strata. A score-based algorithm is provided for therapy guidance.
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| 2. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 3. |
- De Angelis, A., et al.
(författare)
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Science with e-ASTROGAM A space mission for MeV-GeV gamma-ray astrophysics
- 2018
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Ingår i: Journal of High Energy Astrophysics. - : Elsevier. - 2214-4048 .- 2214-4056. ; 19, s. 1-106
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Tidskriftsartikel (refereegranskat)abstract
- e-ASTROGAM ('enhanced ASTROGAM') is a breakthrough Observatory space mission, with a detector composed by a Silicon tracker, a calorimeter, and an anticoincidence system, dedicated to the study of the non-thermal Universe in the photon energy range from 0.3 MeV to 3 GeV - the lower energy limit can be pushed to energies as low as 150 keV for the tracker, and to 30 keV for calorimetric detection. The mission is based on an advanced space-proven detector technology, with unprecedented sensitivity, angular and energy resolution, combined with polarimetric capability. Thanks to its performance in the MeV-GeV domain, substantially improving its predecessors, e-ASTROGAM will open a new window on the non-thermal Universe, making pioneering observations of the most powerful Galactic and extragalactic sources, elucidating the nature of their relativistic outflows and their effects on the surroundings. With a line sensitivity in the MeV energy range one to two orders of magnitude better than previous generation instruments, e-ASTROGAM will determine the origin of key isotopes fundamental for the understanding of supernova explosion and the chemical evolution of our Galaxy. The mission will provide unique data of significant interest to a broad astronomical community, complementary to powerful observatories such as LIGO-Virgo-GEO600-KAGRA, SKA, ALMA, E-ELT, TMT, LSST, JWST, Athena, CTA, IceCube, KM3NeT, and LISA.
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| 4. |
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| 5. |
- Castillo Tapia, Pilar, et al.
(författare)
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V-Band Monolithic Additive-Manufactured Geodesic Lens Array Antenna
- 2023
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Ingår i: IEEE Antennas and Wireless Propagation Letters. - : Institute of Electrical and Electronics Engineers (IEEE). - 1536-1225 .- 1548-5757. ; 22:10, s. 2527-2531
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Tidskriftsartikel (refereegranskat)abstract
- Fully metallic geodesic lens antennas are popular for millimeter-wave band applications due to their simplicity, robustness, and low loss. Here, we report the experimental results of a geodesic lens array antenna, which was specifically designed to be additive-manufactured in one single piece using laser powder-bed fusion (LPBF). LPBF in aluminum alloy AlSi10Mg is able to produce high conductivity and relatively low surface roughness, so the antenna is highly directive and efficient. In addition, LPBF increases the robustness of the design since the lens array is monolithic, i.e., the risks associated with the assembly, including misalignments and undesired air gaps between pieces, are totally eliminated.
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| 6. |
- Fonseca, Nelson J. G., et al.
(författare)
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Fully-Metallic Additively Manufactured Monolithic Double-Ridged Waveguide Rotman Lens in the K/K-a-Band
- 2023
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Ingår i: Sensors. - : MDPI AG. - 1424-8220. ; 23:14, s. 6573-
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Tidskriftsartikel (refereegranskat)abstract
- This paper reports on the design and experimental validation of a fully-metallic doubleridged waveguide 10 x 10 Rotman lens additively manufactured as a single part. The wide band operation of this quasi-optical beamformer enables us to cover the uplink and downlink frequencies allocated to satellite communications in the K/K-a-band, from 17.3GHz to 30 GHz. The feeding port design was adjusted to enable vertical printing, thus minimizing the use of supporting structures. A prototype was manufactured and tested. The reported results indicate losses in the range of 0.5 dB in the lower-frequency band and 0.8 dB in the upper-frequency band, including the waveguide transitions added for test purposes. The measured reflection and coupling coefficients remain below 11.5 dB over the operating band. The standard deviation of the residual phase error across the array ports is below 5 degrees in simulation and below 10 degrees in measurements. Array factors synthesized using the scattering parameters confirm the good stability of the beamforming functionality over the wide frequency band analyzed. This monolithic design is a promising step toward more integrated antenna systems, such as a compact dual-stack configuration for planar array design.
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| 7. |
- Rico-Fernandez, Jose, et al.
(författare)
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Compact and Lightweight Additive Manufactured Parallel-Plate Waveguide Half-Luneburg Geodesic Lens Multiple-Beam Antenna in the K-a-Band
- 2023
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Ingår i: IEEE Antennas and Wireless Propagation Letters. - : Institute of Electrical and Electronics Engineers (IEEE). - 1536-1225 .- 1548-5757. ; 22:4, s. 684-688
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Tidskriftsartikel (refereegranskat)abstract
- In this letter, a parallel-plate waveguide half-Luneburg geodesic lens multiple-beam antenna optimized for additive manufacturing is designed and validated experimentally in the K$_{\mathrm{a}}$-band. Two prototypes were manufactured in AlSi$_{10}$Mg through laser powder-bed fusion and measured in an anechoic chamber. The compact and lightweight prototype optimized for additive manufacturing demonstrates excellent RF performance while significantly reducing mass and mechanical complexity. Specifically, misalignment errors present in previous studies are solved, improving sidelobe level by up to 10 dB. A maximum realized gain of 22.1 dBi is measured at 28 GHz. This single-piece, compact, and lightweight design is particularly attractive for applications having mass restrictions and limited space like millimeter-wave systems on board small satellites.
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