| 1. |
- Blokland, G. A. M., et al.
(författare)
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Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
- 2022
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Ingår i: Biological Psychiatry. - : Elsevier BV. - 0006-3223 .- 1873-2402. ; 91:1, s. 102-117
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Tidskriftsartikel (refereegranskat)abstract
- Background: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. Methods: We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. Results: Across disorders, genome-wide significant single nucleotide polymorphism–by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10−8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p < 1 × 10−6) for cross-disorder G×S interaction (rs7302529, p = 1.6 × 10−7; rs73033497, p = 8.8 × 10−7; rs7914279, p = 6.4 × 10−7), implicating various functions. Gene-based analyses identified G×S interaction across disorders (p = 8.97 × 10−7) with transcriptional inhibitor SLTM. Most significant in SCZ was a MOCOS gene locus (rs11665282, p = 1.5 × 10−7), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509, p = 1.1 × 10−7) in a locus containing IDO2, a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant G×S interaction of genes regulating vascular endothelial growth factor receptor signaling in MDD (false discovery rate-corrected p < .05). Conclusions: In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels. © 2021 Society of Biological Psychiatry
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| 2. |
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| 3. |
- Riley, T.R., et al.
(författare)
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A revised geochronology of Thurston Island, West Antarctica, and correlations along the proto-Pacific margin of Gondwana.
- 2017
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Ingår i: Antarctic Science. - 0954-1020 .- 1365-2079. ; 29, s. 47-60
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Tidskriftsartikel (refereegranskat)abstract
- The continental margin of Gondwana preserves a record of long-lived magmatism from the Andean Cordillera to Australia. The crustal blocks of West Antarctica form part of this margin, with Palaeozoic–Mesozoic magmatism particularly well preserved in the Antarctic Peninsula and Marie Byrd Land. Magmatic events on the intervening Thurston Island crustal block are poorly defined, which has hindered accurate correlations along the margin. Six samples are dated here using U-Pb geochronology and cover the geological history on Thurston Island. The basement gneisses from Morgan Inlet have a protolith age of 349±2 Ma and correlate closely with the Devonian–Carboniferous magmatism of Marie Byrd Land and New Zealand. Triassic (240–220 Ma) magmatism is identified at two sites on Thurston Island, with Hf isotopes indicating magma extraction from Mesoproterozoic-age lower crust. Several sites on Thurston Island preserve rhyolitic tuffs that have been dated at 182 Ma and are likely to correlate with the successions in the Antarctic Peninsula, particularly given the pre-break-up position of the Thurston Island crustal block. Silicic volcanism was widespread in Patagonia and the Antarctic Peninsula at ~ 183 Ma forming the extensive Chon Aike Province. The most extensive episode of magmatism along the active margin took place during the mid-Cretaceous. This Cordillera ‘flare-up’ event of the Gondwana margin is also developed on Thurston Island with granitoid magmatism dated in the interval 110–100 Ma.
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| 4. |
- Riley, T.R., et al.
(författare)
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Early Jurassic magmatism on the Antarctic Peninsula and potential correlation with the Subcordilleran plutonic belt of Patagonia.
- 2017
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Ingår i: Journal of the Geological Society. - : Geological Society of London. - 0016-7649 .- 2041-479X. ; 174, s. 365-376
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Tidskriftsartikel (refereegranskat)abstract
- Early Jurassic silicic volcanic rocks of the Chon Aike Province (V1: 187 – 182 Ma) are 30 recognised from many localities in the southern Antarctic Peninsula and northeast Patagonia and are 31 essentially coeval with the extensive Karoo (182 Ma) and Ferrar (183 Ma) large igneous provinces of 32 pre-breakup Gondwana. Until recently, plutonic rocks of this age were considered either rare or 33 absent from the Antarctic Peninsula batholith, which was thought to have been mainly constructed 34 during the Middle Jurassic and the mid-Cretaceous. New U-Pb zircon geochronology from the 35 Antarctic Peninsula and recently published U-Pb ages from elsewhere on the Peninsula and 36 Patagonia are used to demonstrate the more widespread nature of Early Jurassic plutonism. Eight 37 samples are dated here from the central and southern Antarctic Peninsula. They are all moderately 38 to strongly foliated granitoids (tonalite, granite, granodiorite) and locally represent the crystalline 39 basement. They yield ages in the range 188 – 181 Ma, and overlap with published ages of 185 – 180 40 Ma from granitoids from elsewhere on the Antarctic Peninsula and from the Subcordilleran plutonic 41 belt of Patagonia (185 – 181 Ma). Whilst Early Jurassic plutons of the Subcordilleran plutonic belt of 42 Patagonia are directly related to subduction processes along the proto-Pacific margin of Gondwana, 43 coeval volcanic rocks of the Chon Aike Province are interpreted to be directly associated with 44 extension and plume activity during the initial stages of Gondwana break-up. This indicates that 45 subduction was ongoing when Chon Aike Province volcanism started. The Early Jurassic plutonism on 46 the Antarctic Peninsula is transitional between subduction-related and break-up related 47 magamatism.
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| 5. |
- Riley, T. R., et al.
(författare)
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U-Pb zircon geochronology from Haag Nunataks, Coats Land and Shackleton Range (Antarctica) : Constraining the extent of juvenile Late Mesoproterozoic arc terranes
- 2020
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Ingår i: Precambrian Research. - : Elsevier BV. - 0301-9268 .- 1872-7433. ; 340
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Tidskriftsartikel (refereegranskat)abstract
- Understanding the accretionary stages of Rodinia evolution and the arrangement of cratons and arc terranes is dependent upon high-precision geochronology from key piercing points of Mesoproterozoic rocks. U-Pb zircon dating is presented here from the Mesoproterozoic Haag Nunataks gneiss complex of West Antarctica where the dominant granodiorite protolith was emplaced at 1238 ± 4 Ma, aplite/pegmatite sheets were intruded at 1064 ± 4 Ma and the final intrusive phase of microgranite sheets were emplaced at 1056 ± 8 Ma. A separate magmatic event at ~1170 Ma is recorded as inherited zircons in the later stage intrusions. Based on field relationships, the main phase of deformation at Haag Nunataks is thought to have developed prior to the emplacement of the microgranite sheet at ~1056 Ma but after the ~1064 Ma aplite/pegmatite intrusive phase. Potentially correlative units from the Shackleton Range and Coats Land of East Antarctica are also dated to test supposed correlations with arc terranes and crustal blocks at the margins of Laurentia and the proto-Kalahari craton. An ice-transported granite pegmatite sample recovered from the Brunt Ice Shelf is used as a partial proxy for unexposed rocks of the ice-covered Coats Land block and has been dated at ~1100 Ma. A diorite gneiss from the Shackleton Range was also analysed as it forms part of a magnetic domain shared with the Haag Nunataks crustal block. Core zircon ages of ~2470 Ma were determined, and the age of migmatisation is interpreted at ~1740 Ma and rules out any potential correlation with the Haag Nunataks gneiss complex. The magmatic precursors of the Haag Nunataks orthogneisses were emplaced in a juvenile arc setting. We argue that this arc was located in the Natal Embayment region, contiguous with the Namaqua-Natal-Maud belt of arc terranes typified by enhanced magmatism at ~1240 Ma and ~1170 Ma not associated with any significant deformation events. The later magmatic events at Haag Nunataks at ~1060 Ma are more closely associated with collision of Laurentia with the proto-Kalahari craton and the associated deformation is correlated with the Ottawan phase of the Grenville orogeny.
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| 6. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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