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| 2. |
- van Rheenen, W, et al.
(författare)
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Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
- 2021
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 53:12, s. 1636-
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Tidskriftsartikel (refereegranskat)abstract
- Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons.
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| 3. |
- Perez-Cueto, Federico J. A., et al.
(författare)
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How barriers towards plant-based food consumption differ according to dietary lifestyle : findings from a consumer survey in 10 EU countries
- 2022
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Ingår i: International Journal of Gastronomy and Food Science. - : Elsevier. - 1878-450X .- 1878-4518. ; 29
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Tidskriftsartikel (refereegranskat)abstract
- A diet shift towards a more plant-based food consumption is advocated for sustainable, health and ethical reasons. Still, a diet change remains a societal challenge. The objective of this paper is to identify how barriers towards plant-based food consumption are experienced according to dietary lifestyle in 10 European countries. A pan-EU consumer survey was conducted as part of Smart Protein Project. In total 7590 answers were obtained (49.5% women). Omnivores were more likely to score higher in the barriers to diet shift than vegetarians, vegans or flexitarians. Large effect sizes (Eta squared >0.1) were observed for the following barriers a) the lay belief that humans are meant to eat lots of animal-based meat; b) the expectation that plant-based food products would not be tasty enough; c) and the experience of not enjoying such products. Medium effect sizes (Eta sq. > 0.06) were observed for variables addressing nutrition related barriers “would not be filling enough” and “I would not get energy or strength from these products”. Promotion of plant-based food consumption should be targeted according to diet lifestyle, with focus on their sensory characteristics and on addressing cultural (lay) beliefs e.g. through knowledge sharing.
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| 6. |
- Faber, Ilona, et al.
(författare)
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The mediating role of barriers and trust on the intentions to consume plant-based foods in Europe
- 2024
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Ingår i: Food Quality and Preference. - : Elsevier. - 0950-3293 .- 1873-6343. ; 114
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Tidskriftsartikel (refereegranskat)abstract
- Plant-based food alternatives have increased in popularity, particularly plant-based meat alternatives, while plant-based cheese alternatives less so. However, their acceptance remains low in Europe. Food choice motives (FCM) and trust towards alternative proteins may contribute to purchasing plant-based food alternatives, while other FCM and barriers can hinder this. The present study aimed to investigate whether FCM focused on “Environment & ethics” and “Intrinsic product quality” are associated with behavioural intentions towards plant-based meat and cheese alternatives, and specifically investigating the mediating role of perceived barriers to plant-based food consumption and trust towards plant-based alternative proteins. A survey was conducted in 10 European countries (AT, DE, DK, ES, FR, IT, NL, PL, RO, UK) with quotas on age and gender (N = 7588). Partial Least Squares Structural Equation Modelling (PLS-SEM) was used to determine factors associated with behavioural intentions towards plant-based meat and cheese alternatives. Results showed that “environmental & ethical” motives are positively associated with intentions to consume plant-based alternatives to meat (in 6/10 countries) and cheese (in 8/10 countries). “Intrinsic product quality” motives were not directly associated with behavioural intentions towards plant-based meat alternatives. However, country differences were observed for effects of “Intrinsic product quality”. Perceived barriers to plant-based food consumption and trust towards plant-based alternative proteins play a significant mediating role among all 10 countries. The implications are that environmental and ethical motivations could contribute to effectively promoting plant-based alternatives to meat and dairy. High sensory quality for plant-based meat and cheese alternatives is needed to build trust.
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| 7. |
- Mihai, Oana, 1975, et al.
(författare)
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The effect of Cu-loading on different reactions involved in NH3-SCR over Cu-BEA catalysts
- 2014
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Ingår i: Journal of Catalysis. - : Elsevier BV. - 0021-9517 .- 1090-2694. ; 311, s. 170-181
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we investigate the effect of varying copper loading in Cu-BEA on different reactions involved in the SCR mechanism. The catalysts were characterized by BET, ICP-AES, and UV-Vis. Enlarged ammonia storage was observed when increasing the copper loading mainly owing to loosely bonded NH3, but for over-exchanged samples, a new high-temperature shoulder was also observed. The N2O production significantly grew with increasing copper loading. In addition, the reaction rates of NO oxidation and NH3 oxidation per Cu site were higher on the high-loaded copper samples compared to those with lower loading. However, the opposite results were found for NH3 SCR, but differences were small for this reaction. Ammonium nitrate formation and decomposition were examined during a variety of temperature-programmed desorption (TPD) experiments, and three regions related to the presence of acid sites and low- versus high-loaded copper sites were observed. When dosing NO2 before NH3, ammonium nitrate species were formed but in lower amounts than if NH3 and NO2 were dosed simultaneously.
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| 8. |
- Mihai, Oana, 1975, et al.
(författare)
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The Effect of NO2/NOx Feed Ratio on the NH3-SCR System Over Cu–Zeolites with Varying Copper Loading
- 2014
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Ingår i: Catalysis Letters. - : Springer Science and Business Media LLC. - 1572-879X .- 1011-372X. ; 144:1, s. 70-80
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Tidskriftsartikel (refereegranskat)abstract
- In this study we examine the NO/NO2–NH3-SCR system over Cu–BEA with varying Cu loading. Significantly higher selective catalytic reduction (SCR) activity is observed at low temperature on highly loaded copper samples, whereas the reverse trend is noticed at high temperature. The N2O formation is substantially increased over “over-exchanged” Cu sites, where Cu co-ordinate to one Al and charge-balanced with one OH-group. This is also the case for NO2 reaction with NH3 to produce NO. Using transient experiments the formation/decomposition of ammonium nitrate species are examined. The decomposition depends on the temperature, the sequence of the feed as well as the type of copper species present.
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| 9. |
- Rini, Listia, et al.
(författare)
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Identifying the key success factors of plant-based food brands in Europe
- 2023
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Ingår i: Sustainability. - : MDPI AG. - 2071-1050. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- Plant-based food (PBF) is on the rise as an alternative for animal-based food. Europe is leading in the market size compared with the global market. However, the high failure rate for new food products is challenging the success of new PBF in the market. This paper aims to unravel the key success factors (KSFs) from existing brands, contributing to the knowledge on how to achieve success in PBF market. Two subsequent studies employing online surveys were included, which targeted food expert participants. Study 1 focused on the collection of KSFs related to PBF brands utilizing the card sorting approach. Study 2 employed cluster analysis to further investigate the KSFs among different PBF brands. The findings identified six clusters of KSFs under the external and internal factors supporting the success of the PBF brands. Two (‘Consumer’ and ‘Trend’) and four (‘Ideology’, ‘Marketing strategy’, ‘Innovation management’, and ‘Management structure’) clusters were assigned into external and internal factors, respectively. Furthermore, cluster analysis identified four brand clusters: ‘Mature’, ‘Targeted’, ‘Newcomer’, and ‘Established but diversifying’ clusters. Each brand cluster utilized different KSFs into their strategies; however, both external and internal factors were applied, suggesting that there is no one-size-fits-all KSF to succeed in the market.
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| 10. |
- Rini, Listia, et al.
(författare)
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Social media and food consumer behavior : a systematic review
- 2024
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Ingår i: Trends in Food Science & Technology. - : Elsevier. - 0924-2244 .- 1879-3053. ; 143
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Tidskriftsartikel (refereegranskat)abstract
- Background: Social media (SM) have become the integral part of consumers’ daily life, prompting multidisciplinary research on their link with human behaviors, including food attitude and consumption. However, the precise role of SM in shaping food consumer behavior remains partially explored.Scope and approach: This review adopts a systematic literature approach, focusing on the methodological and outcome characteristics. Applying PRISMA guidelines, 377 studies were identified and categorized into three SM functions: Tool, Determinant, and Source. Tool studies involved active SM use for research, while Determinant studies measured SM-related variables' impact on outcomes, and Source studies involved data extraction and analysis from SM. This review traces the growth of studies over time, highlighting the study characteristics focusing on the methodology, and the scope of the findings per function.Key findings and conclusion: Data collection methods differed across functions: Source studies relying on user-generated content (UGC) via data mining, other functions mostly employed surveys targeted to participants. Notable platforms include Facebook (Tool) and Twitter (Source), with cross-sectional designs being prevalent. Tool and Determinant studies linked SM with food intention and behavior, Source studies delved into categorization and exploration of UGC and consumers’ sentiments related to food. In both the Tool and Determinant functions, most studies demonstrated the influence of SM on outcome measures. As each function has its own distinct characteristics, knowledge from all functions should be considered to gain comprehensive perspective regarding the relationship between SM and food consumer behavior.
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